Association of Thyroid Peroxidase Antibodies and Thyroglobulin Antibodies with Thyroid Function in Pregnancy: An Individual Participant Data Meta-Analysis

doi:10.1089/thy.2022.0083

科研成果详情

题名	Association of Thyroid Peroxidase Antibodies and Thyroglobulin Antibodies with Thyroid Function in Pregnancy: An Individual Participant Data Meta-Analysis
作者	Bliddal, Sofie 1; Derakhshan, Arash 2,3; Xiao, Yi 4; Chen, Liang-Miao5; Mannisto, Tuija 6; Ashoor, Ghalia 7; Tao, Fangbiao 8,9; Brown, Suzanne J.10; Vafeiadi, Marina 11; Itoh, Sachiko 12; Grineva, Elena Nikolaevna 13; Taylor, Peter 14; Ghafoor, Farkhanda 15; Vaidya, Bijay 16; Hattersley, Andrew 17; Mosso, Lorena 18; Oken, Emily 19; Kishi, Reiko 12; Alexander, Erik K.20; Maraka, Spyridoula 21,22,23; Huang, Kun 8; Chaker, Layal 2,3; Bassols, Judit 24; Pirzada, Amna 25; Lopez-Bermejo, Abel 26; Boucai, Laura 27; Peeters, Robin P.2,3; Pearce, Elizabeth N.28; Nelson, Scott McGill 29; Chatzi, Leda 11; Vrijkotte, Tanja G.30; Popova, Polina V.13,31,32; Walsh, John P.10,33; Nicolaides, Kypros H.34; Suvanto, Eila 35; Lu, Xuemian5; Pop, Victor J. M.36; Forman, Julie Lyng 4; Korevaar, Tim I. M.2,3; Feldt-Rasmussen, Ulla 1,37
发表日期	2022-07-01
发表期刊	THYROID 影响因子和分区
语种	英语
原始文献类型	Article
关键词	meta-analysis pregnancy thyroglobulin antibodies thyroid thyroid autoimmunity thyroid peroxidase antibodies
其他关键词	AUTOANTIBODIES ; AUTOIMMUNITY ; DISEASE ; WOMEN ; PREVALENCE ; DIAGNOSIS ; PROGRAM ; RANGES ; RISK
摘要	Objectives: Thyroid autoimmunity is common in pregnant women and associated with thyroid dysfunction and adverse obstetric outcomes. Most studies focus on thyroid peroxidase antibodies (TPOAbs) assessed by a negative-positive dichotomy and rarely take into account thyroglobulin antibodies (TgAbs). This study aimed at determining the association of TPOAbs and TgAbs, respectively, and interdependently, with maternal thyroid function.Methods: This was a meta-analysis of individual participant cross-sectional data from 20 cohorts in the Consortium on Thyroid and Pregnancy. Women with multiple pregnancy, pregnancy by assisted reproductive technology, history of thyroid disease, or use of thyroid interfering medication were excluded. Associations of (log2) TPOAbs and TgAbs (with/without mutual adjustment) with cohort-specific z-scores of (log2) thyrotropin (TSH), free triiodothyronine (fT3), total triiodothyronine (TT3), free thyroxine (fT4), total thyroxine (TT4), or triiodothyronine:thyroxine (T3:T4) ratio were evaluated in a linear mixed model.Results: In total, 51,138 women participated (51,094 had TPOAb-data and 27,874 had TgAb-data). Isolated TPOAb positivity was present in 4.1% [95% confidence interval, CI: 3.0 to 5.2], isolated TgAb positivity in 4.8% [CI: 2.9 to 6.6], and positivity for both antibodies in 4.7% [CI: 3.1 to 6.3]. Compared with antibody-negative women, TSH was higher in women with isolated TPOAb positivity (z-score increment 0.40, CI: 0.16 to 0.64) and TgAb positivity (0.21, CI: 0.10 to 0.32), but highest in those positive for both antibodies (0.54, CI: 0.36 to 0.71). There was a dose-response effect of higher TPOAb and TgAb concentrations with higher TSH (TSH z-score increment for TPOAbs 0.12, CI: 0.09 to 0.15, TgAbs 0.08, CI: 0.02 to 0.15). When adjusting analyses for the other antibody, only the association of TPOAbs remained statistically significant. A higher TPOAb concentration was associated with lower fT4 (p < 0.001) and higher T3:T4 ratio (0.09, CI: 0.03 to 0.14), however, the association with fT4 was not significant when adjusting for TgAbs (p = 0.16).Conclusions: This individual participant data meta-analysis demonstrated an increase in TSH with isolated TPOAb positivity and TgAb positivity, respectively, which was amplified for individuals positive for both antibodies. There was a dose-dependent association of TPOAbs, but not TgAbs, with TSH when adjusting for the other antibody. This supports current practice of using TPOAbs in initial laboratory testing of pregnant women suspected of autoimmune thyroid disease. However, studies on the differences between TPOAb- and TgAb-positive women are needed to fully understand the spectrum of phenotypes.
出版者	MARY ANN LIEBERT, INC
出版地	NEW ROCHELLE
ISSN	1050-7256
EISSN	1557-9077
卷号	32 期号:7 页码:828-840
DOI	10.1089/thy.2022.0083
页数	13
WOS类目	Endocrinology & Metabolism
WOS研究方向	Endocrinology & Metabolism
WOS记录号	WOS:000822759000011
收录类别	SCIE ; PUBMED ; CPCI ; CPCI-S
URL	查看原文
PubMed ID	35596568
通讯作者地址	[Feldt-Rasmussen, Ulla]Copenhagen Univ Hosp, Dept Med Endocrinol & Metab, Rigshosp, Copenhagen, Denmark.
TOP期刊	TOP期刊
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/154453
专题	其他_温州市第三临床学院（温州市人民医院）
通讯作者	Feldt-Rasmussen, Ulla
作者单位	1.Copenhagen Univ Hosp, Dept Med Endocrinol & Metab, Rigshosp, Copenhagen, Denmark; 2.Erasmus MC, Dept Internal Med, Rotterdam, Netherlands; 3.Erasmus MC, Acad Ctr Thyroid Dis, Rotterdam, Netherlands; 4.Univ Copenhagen, Dept Publ Hlth, Sect Biostat, Copenhagen, Denmark; 5.Wenzhou Med Univ, Dept Endocrinol, Affiliated Hosp 3, Wenzhou, Peoples R China; 6.Oulu Univ Hosp, Northern Finland Lab Ctr Nordlab, Oulu, Finland; 7.Kings Coll Hosp London, Harris Birthright Res Ctr Fetal Med, London, England; 8.Anhui Med Univ, Sch Publ Hlth, Dept Maternal Child & Adolescent Hlth, Hefei, Peoples R China; 9.Anhui Prov Key Lab Populat Hlth & Aristogen, Hefei, Peoples R China; 10.Sir Charles Gairdner Hosp, Dept Endocrinol & Diabet, Ruian Ctr Chinese, Affiliated Hosp 3, Nedlands, Australia; 11.Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA USA; 12.Hokkaido Univ, Ctr Environm & Hlth Sci, Sapporo, Japan; 13.Almazov Natl Med Res Ctr, Fac Med, Ctr Translat Endocrinol CETREN, Dept Endocrinol, Santiago, Russia; 14.Cardiff Univ, Inst Mol & Expt Med, Sch Med, Thyroid Res Grp, Oulu, Wales; 15.Res & Innovat Shalamar Inst Hlth Sci, Dept Med Endocrinol & Metab, Rigshosp, 2132Blegdamsvej 9, DK-2100 Lahore, Pakistan; 16.Univ Exeter Med Sch, Royal Devon & Exeter Hosp NHS Fdn Trust, Dept Endocrinol, Exeter, Devon, England; 17.Univ Exeter Med Sch, Royal Devon & Exeter Hosp, Exeter, Devon, England; 18.Pontificia Univ Catolica Chile, Fac Med, Endocrinol Dept, Santiago, Chile; 19.Harvard Med Sch, Brigham & Womens Hosp, Dept Populat Med Hypertens & Diabet, Div Chron Dis Res Lifecourse, Boston, MA USA; 20.Harvard Med Sch, Brigham & Womens Hosp, Div Endocrinol Hypertens & Diabet, Boston, MA USA; 21.Univ Arkansas Med Sci, Div Endocrinol & Metab, Little Rock, AR USA; 22.Mayo Clin Minnesota, Dept Med, Div Endocrinol Diabet Metab & Nutr, Knowledge & Evaluat Res Unit, Rochester, MN USA; 23.Cent Arkansas Vet Healthcare Syst, Little Rock, AR USA; 24.Dr Josep Trueta Hosp, Girona Biomed Res Inst IDIBGI, Maternal Fetal Metab Res Grp, Girona, Spain; 25.Shifa Int Hosp, Shifa Inst Med Technol, Islamabad, Pakistan; 26.Dr Josep Trueta Hosp, Girona Biomed Res Inst IDIBGI, Pediat Endocrinol Res Grp, Girona, Spain; 27.Weill Cornell Univ, Mem Sloan Kettering Canc Ctr, Dept Med, Div Endocrinol, New York, NY USA; 28.Boston Univ Sch Med, Sect Endocrinol Diabet & Nutr, Boston, MA USA; 29.Univ Glasgow, Sch Med, Glasgow City, Scotland; 30.Univ Amsterdam, Amsterdam Publ Hlth Res Inst, Dept Publ Hlth, Amsterdam UMC, Amsterdam, Netherlands; 31.St Petersburg Pavlov State Med Univ, Dept Internal Dis & Endocrinol, St Petersburg, Russia; 32.Almazov Natl Med Res Ctr, World Class Res Ctr Personalized Med, St Petersburg, Russia; 33.Univ Western Australia, Med Sch, Crawley, Australia; 34.Kings Coll London, Fac Life Sci & Med, Dept Women & Childrens Hlth, London, England; 35.Univ Oulu, Dept Obstet & Gynecol, Oulu, Finland; 36.Tilburg Univ, Dept Med & Clin Psychol, Tilburg, Netherlands; 37.Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark
推荐引用方式 GB/T 7714	Bliddal, Sofie,Derakhshan, Arash,Xiao, Yi,et al. Association of Thyroid Peroxidase Antibodies and Thyroglobulin Antibodies with Thyroid Function in Pregnancy: An Individual Participant Data Meta-Analysis[J]. THYROID,2022,32(7):828-840.
APA	Bliddal, Sofie., Derakhshan, Arash., Xiao, Yi., Chen, Liang-Miao., Mannisto, Tuija., ... & Feldt-Rasmussen, Ulla. (2022). Association of Thyroid Peroxidase Antibodies and Thyroglobulin Antibodies with Thyroid Function in Pregnancy: An Individual Participant Data Meta-Analysis. THYROID, 32(7), 828-840.
MLA	Bliddal, Sofie,et al."Association of Thyroid Peroxidase Antibodies and Thyroglobulin Antibodies with Thyroid Function in Pregnancy: An Individual Participant Data Meta-Analysis".THYROID 32.7(2022):828-840.