Correlations Between Iron Status and Body Composition in Patients With Type 2 Diabetes Mellitus

doi:10.3389/fnut.2022.911860

科研成果详情

题名	Correlations Between Iron Status and Body Composition in Patients With Type 2 Diabetes Mellitus
作者	Zimiao, Chen 1; Dongdong, Luo 2; Shuoping, Chen 1; Peng, Zhou 3; Fan, Zheng 4; Rujun, Chen 5; Xiaohua, Gong 1
发表日期	2022-07-13
发表期刊	FRONTIERS IN NUTRITION 影响因子和分区
语种	英语
原始文献类型	Article
关键词	type 2 diabetes mellitus body composition visceral fat mass android-to-gynoid fat ratio iron metabolism
其他关键词	ACCUMULATION ; POPULATION ; ADIPOSITY ; DISEASE ; RISK
摘要	BackgroundOur study aimed to investigate the association between iron metabolism and body composition in patients with type 2 diabetes mellitus (T2DM). MethodsA total of 824 patients with T2DM were enrolled. Measurements of body composition were obtained by dual-energy X-ray absorptiometry. Patients were stratified into three groups according to their sex-specific ferritin levels. Basic information, laboratory results, and body composition were collected. ResultsSerum iron and transferrin saturation (TSAT) were increased significantly with increased serum ferritin (all p < 0.05). Total iron-binding capacity (TIBC) was decreased significantly with increased serum ferritin (p < 0.05). Visceral fat mass (VF), android fat/total body fat mass, android-to-gynoid fat ratio (A/G ratio), and high-sensitivity C-reactive protein were all increased significantly with increased serum ferritin (all p < 0.05). Patients with a high A/G ratio (A/G ratio >= 1) had significantly higher serum iron, ferritin, and TSAT, but significantly lower TIBC. In the model adjusted for age and gender, higher ferritin levels were associated with a higher VF (all p < 0.05). Serum iron was positively correlated with the occurrence of a high A/G ratio (A/G ratio >= 1) after the adjustment of confounding factors [an odds ratio (OR = 1.09, 95% CI, 1.02-1.19, p = 0.02)]. With receiver operating curve analysis, the cutoff value of serum iron for a high A/G ratio was 18.56, and the area under the curve was 0.771 (sensitivity 88.9%and specificity 63.9%, p = 0.01). ConclusionHigher serum iron and ferritin concentrations were positively associated with a higher VF. Higher serum iron concentrations were positively correlated with a high A/G ratio. This study indicates the potential relationship between iron overload and the body composition in patients with T2DM.
资助项目	Natural Science Foundation of Zhejiang Province
出版者	FRONTIERS MEDIA SA
出版地	LAUSANNE
ISSN	2296-861X
卷号	9 页码:911860
DOI	10.3389/fnut.2022.911860
页数	8
WOS类目	Nutrition & Dietetics
WOS研究方向	Nutrition & Dietetics
WOS记录号	WOS:000832708800001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	35911095
SCOPUSEID	2-s2.0-85134968286
通讯作者地址	[Xiaohua, Gong]Department of Endocrinology and Metabolism,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China ; [Rujun, Chen]Department of Burn,906 Hospital of the Joint Logistics Team,PLA,Wenzhou,China
Scopus学科分类	Food Science;Endocrinology, Diabetes and Metabolism;Nutrition and Dietetics
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/154414
专题	附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_精神病与精神卫生学
通讯作者	Rujun, Chen; Xiaohua, Gong
作者单位	1.Department of Endocrinology and Metabolism,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.Department of Endocrinology and Metabolism,The Second Affiliated Hospital of Dalian Medical University,Dalian Medical University,Dalian,China; 3.Central Hospital of Qiaoxia Town,Wenzhou,China; 4.College of Psychiatry,Wenzhou Medical University,Wenzhou,China; 5.Department of Burn,906 Hospital of the Joint Logistics Team,PLA,Wenzhou,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Zimiao, Chen,Dongdong, Luo,Shuoping, Chen,et al. Correlations Between Iron Status and Body Composition in Patients With Type 2 Diabetes Mellitus[J]. FRONTIERS IN NUTRITION,2022,9:911860.
APA	Zimiao, Chen., Dongdong, Luo., Shuoping, Chen., Peng, Zhou., Fan, Zheng., ... & Xiaohua, Gong. (2022). Correlations Between Iron Status and Body Composition in Patients With Type 2 Diabetes Mellitus. FRONTIERS IN NUTRITION, 9, 911860.
MLA	Zimiao, Chen,et al."Correlations Between Iron Status and Body Composition in Patients With Type 2 Diabetes Mellitus".FRONTIERS IN NUTRITION 9(2022):911860.