科研成果详情

题名Macrophage membrane-biomimetic adhesive polycaprolactone nanocamptothecin for improving cancer-targeting efficiency and impairing metastasis
作者
发表日期2023-02
发表期刊BIOACTIVE MATERIALS   影响因子和分区
语种英语
原始文献类型Article
关键词Polymer prodrug Macrophage membrane Cancer nanomedicine Antimetastasis Nanocamptothecin
其他关键词CELL-MEMBRANE ; COMPLEMENT ACTIVATION ; NANOPARTICLES ; FORMULATIONS ; EXPRESSION ; PATHWAYS ; RECEPTOR ; VCAM-1
摘要The recent remarkable success and safety of mRNA lipid nanoparticle technology for producing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines has stimulated intensive efforts to expand nano -particle strategies to treat various diseases. Numerous synthetic nanoparticles have been developed for phar-maceutical delivery and cancer treatment. However, only a limited number of nanotherapies have enter clinical trials or are clinically approved. Systemically administered nanotherapies are likely to be sequestered by host mononuclear phagocyte system (MPS), resulting in suboptimal pharmacokinetics and insufficient drug concen-trations in tumors. Bioinspired drug-delivery formulations have emerged as an alternative approach to evade the MPS and show potential to improve drug therapeutic efficacy. Here we developed a biodegradable polymer -conjugated camptothecin prodrug encapsulated in the plasma membrane of lipopolysaccharide-stimulated macrophages. Polymer conjugation revived the parent camptothecin agent (e.g., 7-ethyl-10-hydroxy-camptothe-cin), enabling lipid nanoparticle encapsulation. Furthermore, macrophage membrane cloaking transformed the nonadhesive lipid nanoparticles into bioadhesive nanocamptothecin, increasing the cellular uptake and tumor -tropic effects of this biomimetic therapy. When tested in a preclinical murine model of breast cancer, macrophage-camouflaged nanocamptothecin exhibited a higher level of tumor accumulation than uncoated nanoparticles. Furthermore, intravenous administration of the therapy effectively suppressed tumor growth and the metastatic burden without causing systematic toxicity. Our study describes a combinatorial strategy that uses polymeric prodrug design and cell membrane cloaking to achieve therapeutics with high efficacy and low toxicity. This approach might also be generally applicable to formulate other therapeutic candidates that are not compatible or miscible with biomimetic delivery carriers.
资助项目Zhejiang Provincial Natural Science Foundation of China [LR19H160002]; National Natural Science Foundation of China [82073296, 81773193]; Research Project of Jinan Microecological Biomedicine Shandong Laboratory [JNL- 2022010B]
出版者KEAI PUBLISHING LTD
出版地BEIJING
ISSN2452-199X
EISSN2452-199X
卷号20页码:449-462
DOI10.1016/j.bioactmat.2022.06.013
页数14
WOS类目Engineering, Biomedical ; Materials Science, Biomaterials
WOS研究方向Engineering ; Materials Science
WOS记录号WOS:000829813200001
收录类别SCIE ; PUBMED ; SCOPUS
URL查看原文
PubMed ID35765468
SCOPUSEID2-s2.0-85132907567
ESI高被引论文2023-05 ; 2023-07 ; 2023-09 ; 2023-11 ; 2024-01 ; 2024-03 ; 2024-05 ; 2024-07 ; 2024-09
通讯作者地址[Wang, Hangxiang]The First Affiliated Hospital,Zhejiang University School of Medicine,79, Qingchun Road,Hangzhou,310003,China ; [Xie, Binbin]Department of Medical Oncology,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Zhejiang Province,Hangzhou,310016,China
Scopus学科分类Biotechnology;Biomaterials;Biomedical Engineering
TOP期刊TOP期刊
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被引频次[WOS]:0   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/154140
专题第一临床医学院(信息与工程学院)、附属第一医院
附属第一医院
通讯作者Xie, Binbin; Wang, Hangxiang
作者单位
1.The First Affiliated Hospital,NHC Key Laboratory of Combined Multi-Organ Transplantation,Zhejiang University School of Medicine,Zhejiang Province,Hangzhou,310003,China;
2.Jinan Microecological Biomedicine Shandong Laboratory,Shandong Province,Jinan,250117,China;
3.Department of Hepatobiliary Surgery,The First Affiliated Hospital,Wenzhou Medical University,Zhejiang Province,Wenzhou,325000,China;
4.Department of Medical Oncology,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Zhejiang Province,Hangzhou,310016,China;
5.Department of Chemical Engineering,Zhejiang University,Zhejiang Province,Hangzhou,310027,China
推荐引用方式
GB/T 7714
Ying, Kangkang,Zhu, Yifeng,Wan, Jianqin,et al. Macrophage membrane-biomimetic adhesive polycaprolactone nanocamptothecin for improving cancer-targeting efficiency and impairing metastasis[J]. BIOACTIVE MATERIALS,2023,20:449-462.
APA Ying, Kangkang., Zhu, Yifeng., Wan, Jianqin., Zhan, Chenyue., Wang, Yuchen., ... & Wang, Hangxiang. (2023). Macrophage membrane-biomimetic adhesive polycaprolactone nanocamptothecin for improving cancer-targeting efficiency and impairing metastasis. BIOACTIVE MATERIALS, 20, 449-462.
MLA Ying, Kangkang,et al."Macrophage membrane-biomimetic adhesive polycaprolactone nanocamptothecin for improving cancer-targeting efficiency and impairing metastasis".BIOACTIVE MATERIALS 20(2023):449-462.

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