Macrophage membrane-biomimetic adhesive polycaprolactone nanocamptothecin for improving cancer-targeting efficiency and impairing metastasis

doi:10.1016/j.bioactmat.2022.06.013

科研成果详情

题名	Macrophage membrane-biomimetic adhesive polycaprolactone nanocamptothecin for improving cancer-targeting efficiency and impairing metastasis
作者	Ying, Kangkang 1,2,4; Zhu, Yifeng3; Wan, Jianqin 1; Zhan, Chenyue 1; Wang, Yuchen 1,5; Xie, Binbin 4; Xu, Peirong 1,5; Pan, Hongming 4; Wang, Hangxiang 1,2,3,6
发表期刊	BIOACTIVE MATERIALS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Polymer prodrug Macrophage membrane Cancer nanomedicine Antimetastasis Nanocamptothecin
其他关键词	CELL-MEMBRANE ; COMPLEMENT ACTIVATION ; NANOPARTICLES ; FORMULATIONS ; EXPRESSION ; PATHWAYS ; RECEPTOR ; VCAM-1
摘要	The recent remarkable success and safety of mRNA lipid nanoparticle technology for producing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines has stimulated intensive efforts to expand nano -particle strategies to treat various diseases. Numerous synthetic nanoparticles have been developed for phar-maceutical delivery and cancer treatment. However, only a limited number of nanotherapies have enter clinical trials or are clinically approved. Systemically administered nanotherapies are likely to be sequestered by host mononuclear phagocyte system (MPS), resulting in suboptimal pharmacokinetics and insufficient drug concen-trations in tumors. Bioinspired drug-delivery formulations have emerged as an alternative approach to evade the MPS and show potential to improve drug therapeutic efficacy. Here we developed a biodegradable polymer -conjugated camptothecin prodrug encapsulated in the plasma membrane of lipopolysaccharide-stimulated macrophages. Polymer conjugation revived the parent camptothecin agent (e.g., 7-ethyl-10-hydroxy-camptothe-cin), enabling lipid nanoparticle encapsulation. Furthermore, macrophage membrane cloaking transformed the nonadhesive lipid nanoparticles into bioadhesive nanocamptothecin, increasing the cellular uptake and tumor -tropic effects of this biomimetic therapy. When tested in a preclinical murine model of breast cancer, macrophage-camouflaged nanocamptothecin exhibited a higher level of tumor accumulation than uncoated nanoparticles. Furthermore, intravenous administration of the therapy effectively suppressed tumor growth and the metastatic burden without causing systematic toxicity. Our study describes a combinatorial strategy that uses polymeric prodrug design and cell membrane cloaking to achieve therapeutics with high efficacy and low toxicity. This approach might also be generally applicable to formulate other therapeutic candidates that are not compatible or miscible with biomimetic delivery carriers.
资助项目	Zhejiang Provincial Natural Science Foundation of China [LR19H160002]; National Natural Science Foundation of China [82073296, 81773193]; Research Project of Jinan Microecological Biomedicine Shandong Laboratory [JNL- 2022010B]
出版者	KEAI PUBLISHING LTD
出版地	BEIJING
ISSN	2452-199X
EISSN	2452-199X
卷号	20 页码:449-462
DOI	10.1016/j.bioactmat.2022.06.013
页数	14
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials
WOS研究方向	Engineering ; Materials Science
WOS记录号	WOS:000829813200001
收录类别	SCIE ; PUBMED ; SCOPUS
发表日期	2023-02
URL	查看原文
Pubmed记录号	35765468
Scopus记录号	2-s2.0-85132907567
ESI高被引论文	2023-05 ; 2023-07 ; 2023-09 ; 2023-11 ; 2024-01 ; 2024-03 ; 2024-05
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/154140
专题	附属第一医院
通讯作者	Xie, Binbin; Wang, Hangxiang
作者单位	1.Zhejiang Univ, Affiliated Hosp 1, NHC Key Lab Combined Multiorgan Transplantat, Sch Med, Hangzhou 310003, Zhejiang, Peoples R China; 2.Jinan Microecol Biomed Shandong Lab, Jinan 250117, Shandong, Peoples R China; 3.Wenzhou Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Wenzhou 325000, Zhejiang, Peoples R China; 4.Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Med Oncol, Sch Med, Hangzhou 310016, Zhejiang, Peoples R China; 5.Zhejiang Univ, Dept Chem Engn, Hangzhou 310027, Zhejiang, Peoples R China; 6.Zhejiang Univ, Affiliated Hosp 1, Sch Med, 79 Qingchun Rd, Hangzhou 310003, Peoples R China
通讯作者单位	附属第一医院; 肝胆外科
推荐引用方式 GB/T 7714	Ying, Kangkang,Zhu, Yifeng,Wan, Jianqin,et al. Macrophage membrane-biomimetic adhesive polycaprolactone nanocamptothecin for improving cancer-targeting efficiency and impairing metastasis[J]. BIOACTIVE MATERIALS,2023,20:449-462.
APA	Ying, Kangkang., Zhu, Yifeng., Wan, Jianqin., Zhan, Chenyue., Wang, Yuchen., ... & Wang, Hangxiang. (2023). Macrophage membrane-biomimetic adhesive polycaprolactone nanocamptothecin for improving cancer-targeting efficiency and impairing metastasis. BIOACTIVE MATERIALS, 20, 449-462.
MLA	Ying, Kangkang,et al."Macrophage membrane-biomimetic adhesive polycaprolactone nanocamptothecin for improving cancer-targeting efficiency and impairing metastasis".BIOACTIVE MATERIALS 20(2023):449-462.