题名 | Macrophage membrane-biomimetic adhesive polycaprolactone nanocamptothecin for improving cancer-targeting efficiency and impairing metastasis |
作者 | |
发表日期 | 2023-02 |
发表期刊 | BIOACTIVE MATERIALS 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article |
关键词 | Polymer prodrug Macrophage membrane Cancer nanomedicine Antimetastasis Nanocamptothecin |
其他关键词 | CELL-MEMBRANE ; COMPLEMENT ACTIVATION ; NANOPARTICLES ; FORMULATIONS ; EXPRESSION ; PATHWAYS ; RECEPTOR ; VCAM-1 |
摘要 | The recent remarkable success and safety of mRNA lipid nanoparticle technology for producing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines has stimulated intensive efforts to expand nano -particle strategies to treat various diseases. Numerous synthetic nanoparticles have been developed for phar-maceutical delivery and cancer treatment. However, only a limited number of nanotherapies have enter clinical trials or are clinically approved. Systemically administered nanotherapies are likely to be sequestered by host mononuclear phagocyte system (MPS), resulting in suboptimal pharmacokinetics and insufficient drug concen-trations in tumors. Bioinspired drug-delivery formulations have emerged as an alternative approach to evade the MPS and show potential to improve drug therapeutic efficacy. Here we developed a biodegradable polymer -conjugated camptothecin prodrug encapsulated in the plasma membrane of lipopolysaccharide-stimulated macrophages. Polymer conjugation revived the parent camptothecin agent (e.g., 7-ethyl-10-hydroxy-camptothe-cin), enabling lipid nanoparticle encapsulation. Furthermore, macrophage membrane cloaking transformed the nonadhesive lipid nanoparticles into bioadhesive nanocamptothecin, increasing the cellular uptake and tumor -tropic effects of this biomimetic therapy. When tested in a preclinical murine model of breast cancer, macrophage-camouflaged nanocamptothecin exhibited a higher level of tumor accumulation than uncoated nanoparticles. Furthermore, intravenous administration of the therapy effectively suppressed tumor growth and the metastatic burden without causing systematic toxicity. Our study describes a combinatorial strategy that uses polymeric prodrug design and cell membrane cloaking to achieve therapeutics with high efficacy and low toxicity. This approach might also be generally applicable to formulate other therapeutic candidates that are not compatible or miscible with biomimetic delivery carriers. |
资助项目 | Zhejiang Provincial Natural Science Foundation of China [LR19H160002]; National Natural Science Foundation of China [82073296, 81773193]; Research Project of Jinan Microecological Biomedicine Shandong Laboratory [JNL- 2022010B] |
出版者 | KEAI PUBLISHING LTD |
出版地 | BEIJING |
ISSN | 2452-199X |
EISSN | 2452-199X |
卷号 | 20页码:449-462 |
DOI | 10.1016/j.bioactmat.2022.06.013 |
页数 | 14 |
WOS类目 | Engineering, Biomedical ; Materials Science, Biomaterials |
WOS研究方向 | Engineering ; Materials Science |
WOS记录号 | WOS:000829813200001 |
收录类别 | SCIE ; PUBMED ; SCOPUS |
URL | 查看原文 |
PubMed ID | 35765468 |
SCOPUSEID | 2-s2.0-85132907567 |
ESI高被引论文 | 2023-05 ; 2023-07 ; 2023-09 ; 2023-11 ; 2024-01 ; 2024-03 ; 2024-05 ; 2024-07 ; 2024-09 |
通讯作者地址 | [Wang, Hangxiang]The First Affiliated Hospital,Zhejiang University School of Medicine,79, Qingchun Road,Hangzhou,310003,China ; [Xie, Binbin]Department of Medical Oncology,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Zhejiang Province,Hangzhou,310016,China |
Scopus学科分类 | Biotechnology;Biomaterials;Biomedical Engineering |
TOP期刊 | TOP期刊 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/154140 |
专题 | 第一临床医学院(信息与工程学院)、附属第一医院 附属第一医院 |
通讯作者 | Xie, Binbin; Wang, Hangxiang |
作者单位 | 1.The First Affiliated Hospital,NHC Key Laboratory of Combined Multi-Organ Transplantation,Zhejiang University School of Medicine,Zhejiang Province,Hangzhou,310003,China; 2.Jinan Microecological Biomedicine Shandong Laboratory,Shandong Province,Jinan,250117,China; 3.Department of Hepatobiliary Surgery,The First Affiliated Hospital,Wenzhou Medical University,Zhejiang Province,Wenzhou,325000,China; 4.Department of Medical Oncology,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Zhejiang Province,Hangzhou,310016,China; 5.Department of Chemical Engineering,Zhejiang University,Zhejiang Province,Hangzhou,310027,China |
推荐引用方式 GB/T 7714 | Ying, Kangkang,Zhu, Yifeng,Wan, Jianqin,et al. Macrophage membrane-biomimetic adhesive polycaprolactone nanocamptothecin for improving cancer-targeting efficiency and impairing metastasis[J]. BIOACTIVE MATERIALS,2023,20:449-462. |
APA | Ying, Kangkang., Zhu, Yifeng., Wan, Jianqin., Zhan, Chenyue., Wang, Yuchen., ... & Wang, Hangxiang. (2023). Macrophage membrane-biomimetic adhesive polycaprolactone nanocamptothecin for improving cancer-targeting efficiency and impairing metastasis. BIOACTIVE MATERIALS, 20, 449-462. |
MLA | Ying, Kangkang,et al."Macrophage membrane-biomimetic adhesive polycaprolactone nanocamptothecin for improving cancer-targeting efficiency and impairing metastasis".BIOACTIVE MATERIALS 20(2023):449-462. |
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