High Fibrinogen to Albumin Ratio: A Novel Marker for Risk of Stroke-Associated Pneumonia?

doi:10.3389/fneur.2021.747118

科研成果详情

题名	High Fibrinogen to Albumin Ratio: A Novel Marker for Risk of Stroke-Associated Pneumonia?
作者	Lin, Gangqiang 1; Hu, Minlei 2; Song, Jiaying 3; Xu, Xueqian 1; Liu, Haiwei 1; Qiu, Linan 1; Zhu, Hanyu1; Xu, Minjie3; Geng, Dandan1; Yang, Lexuan 1; Huang, Guiqian1; He, Jincai1; Wang, Zhen1
发表日期	2022-01-13
发表期刊	FRONTIERS IN NEUROLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	acute ischemic stroke stroke-associated pneumonia coagulation inflammation fibrinogen albumin
其他关键词	ISCHEMIC-STROKE ; MEDICAL COMPLICATIONS ; SERUM-ALBUMIN ; TRANSENDOTHELIAL MIGRATION ; PREDICT PNEUMONIA ; INFLAMMATION ; MORTALITY ; LEVEL ; SCORE ; INFECTION
摘要	Background: Stroke-associated pneumonia (SAP) is associated with poor prognosis after acute ischemic stroke (AIS).Purpose: This study aimed to describe the parameters of coagulation function and evaluate the association between the fibrinogen-to-albumin ratio (FAR) and SAP in patients with AIS.Patients and methods: A total of 932 consecutive patients with AIS were included. Coagulation parameters were measured at admission. All patients were classified into two groups according to the optimal cutoff FAR point at which the sum of the specificity and sensitivity was highest. Propensity score matching (PSM) was performed to balance potential confounding factors. Univariate and multivariate logistic regression analyses were applied to identify predictors of SAP.Results: A total of 100 (10.7%) patients were diagnosed with SAP. The data showed that fibrinogen, FAR, and D-dimer, prothrombin time (PT), activated partial thromboplastin time (aPTT) were higher in patients with SAP, while albumin was much lower. Patients with SAP showed a significantly increased FAR when compared with non-SAP (P < 0.001). Patients were assigned to groups of high FAR (>= 0.0977) and low FAR (<0.0977) based on the optimal cut-off value. Propensity score matching analysis further confirmed the association between FAR and SAP. After adjusting for confounding and risk factors, multivariate regression analysis showed that the high FAR (>= 0.0977) was an independent variable predicting the occurrence of SAP (odds ratio =2.830, 95% CI = 1.654-4.840, P < 0.001). In addition, the FAR was higher in the severe pneumonia group when it was assessed by pneumonia severity index (P = 0.008).Conclusions: High FAR is an independent potential risk factor of SAP, which can help clinicians identify high-risk patients with SAP after AIS.
资助项目	Institute of Aging[LY19H090013];
出版者	FRONTIERS MEDIA SA
出版地	LAUSANNE
ISSN	1664-2295
卷号	12 页码:747118
DOI	10.3389/fneur.2021.747118
页数	10
WOS类目	Clinical Neurology ; Neurosciences
WOS研究方向	Neurosciences & Neurology
WOS记录号	WOS:000748037900001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	35095715
PMC记录号	PMC8792987
SCOPUSEID	2-s2.0-85123790174
通讯作者地址	[Huang, Guiqian]Department of Neurology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China ; [He, Jincai]Department of Neurology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China ; [Wang, Zhen]Department of Neurology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Neurology;Neurology (clinical)
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/15414
专题	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科精神医学学院
通讯作者	Huang, Guiqian; He, Jincai; Wang, Zhen
作者单位	1.Department of Neurology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.Department of Neurology,The First Hospital of Jiaxing,Jiaxing,China; 3.School of Mental Health,Wenzhou Medical University,Wenzhou,China
第一作者单位	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科
通讯作者单位	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科
第一作者的第一单位	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科
推荐引用方式 GB/T 7714	Lin, Gangqiang,Hu, Minlei,Song, Jiaying,et al. High Fibrinogen to Albumin Ratio: A Novel Marker for Risk of Stroke-Associated Pneumonia?[J]. FRONTIERS IN NEUROLOGY,2022,12:747118.
APA	Lin, Gangqiang., Hu, Minlei., Song, Jiaying., Xu, Xueqian., Liu, Haiwei., ... & Wang, Zhen. (2022). High Fibrinogen to Albumin Ratio: A Novel Marker for Risk of Stroke-Associated Pneumonia?. FRONTIERS IN NEUROLOGY, 12, 747118.
MLA	Lin, Gangqiang,et al."High Fibrinogen to Albumin Ratio: A Novel Marker for Risk of Stroke-Associated Pneumonia?".FRONTIERS IN NEUROLOGY 12(2022):747118.