科研成果详情

题名Effects of berberine on the expressions of NRF2 and HO-1 in endothelial cells of diabetic rat
作者
发表日期2017-12-31
发表期刊BIOMEDICAL RESEARCH-INDIA   影响因子和分区
语种英语
原始文献类型Article
关键词Berberine Diabetes NRF2 HO-1
其他关键词EPIGENETIC MODIFICATIONS ; PROTECTIVE ROLE ; NADPH OXIDASE ; RETINOPATHY ; COMPLICATIONS ; MELLITUS ; SYSTEM ; PLAYS
摘要Objective: This study aims to investigate the effects of berberine on the expression of nuclear factor erythroid 2-related factor 2 (Nrf2)/Heme Oxygenase 1 (HO-1) in retinal cells of diabetic rats. Methods: The diabetic rat models were established through intraperitoneal injection of streptozotocin. Different concentration (50 mg/kg/d, 100 mg/kg/d, 200 mg/kg/d) of berberine was orally administered to the rats for 4 weeks. After 4 weeks, changes of body weight, blood lipid and glucose were detected, and the expression levels of Nrf2 and HO-1 in retinal tissues were evaluated by immunohistochemistry and Western blot. Results: Four weeks of berberine intervention decreased blood glucose to below 16 mmol/L. Total Cholesterol (TC), Triglyceride (TG), and Low-Density Lipoprotein cholesterol (LDL) was decreased significantly, while High-Density Lipoprotein cholesterol (HDL) was increased significantly than that in the model group (P<0.05). The expressions of Nrf2 and HO-1 were also decreased in retinal cells after berberine treatment compared with those in the model group. Conclusion: Berberine can reduce blood glucose level in diabetic rats, improve blood lipid and decrease retinal vascular injury, suggesting it may be associated with the reduced expressions of Nrf2/HO-1.
出版者ALLIED ACAD
出版地LONDON
ISSN0970-938X
EISSN0976-1683
卷号28期号:9页码:3860-3864
页数5
WOS类目Engineering, Biomedical ; Medicine, Research & Experimental
WOS研究方向Engineering ; Research & Experimental Medicine
WOS记录号WOS:000403460100013
收录类别SCIE ; SCOPUS
URL查看原文
SCOPUSEID2-s2.0-85019653914
通讯作者地址[Wang, Lingyun]Outpatient Department,The First Affiliated Hospital of Wenzhou Medical University,China
Scopus学科分类Biochemistry, Genetics and Molecular Biology (all)
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/15385
专题附属第一医院_门诊部
通讯作者Wang, Lingyun
作者单位
1.Department of Endocrinology,Wenzhou Central Hospital,Wenzhou,325000,China;
2.Outpatient Department,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
通讯作者单位附属第一医院;  第一临床医学院(信息与工程学院)、附属第一医院
推荐引用方式
GB/T 7714
Tao, Kai,Chen, Jinghai,Wang, Lingyun. Effects of berberine on the expressions of NRF2 and HO-1 in endothelial cells of diabetic rat[J]. BIOMEDICAL RESEARCH-INDIA,2017,28(9):3860-3864.
APA Tao, Kai, Chen, Jinghai, & Wang, Lingyun. (2017). Effects of berberine on the expressions of NRF2 and HO-1 in endothelial cells of diabetic rat. BIOMEDICAL RESEARCH-INDIA, 28(9), 3860-3864.
MLA Tao, Kai,et al."Effects of berberine on the expressions of NRF2 and HO-1 in endothelial cells of diabetic rat".BIOMEDICAL RESEARCH-INDIA 28.9(2017):3860-3864.

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