Effects of berberine on the expressions of NRF2 and HO-1 in endothelial cells of diabetic rat

科研成果详情

题名	Effects of berberine on the expressions of NRF2 and HO-1 in endothelial cells of diabetic rat
作者	Tao, Kai 1; Chen, Jinghai 1; Wang, Lingyun2
发表日期	2017-12-31
发表期刊	BIOMEDICAL RESEARCH-INDIA 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Berberine Diabetes NRF2 HO-1
其他关键词	EPIGENETIC MODIFICATIONS ; PROTECTIVE ROLE ; NADPH OXIDASE ; RETINOPATHY ; COMPLICATIONS ; MELLITUS ; SYSTEM ; PLAYS
摘要	Objective: This study aims to investigate the effects of berberine on the expression of nuclear factor erythroid 2-related factor 2 (Nrf2)/Heme Oxygenase 1 (HO-1) in retinal cells of diabetic rats. Methods: The diabetic rat models were established through intraperitoneal injection of streptozotocin. Different concentration (50 mg/kg/d, 100 mg/kg/d, 200 mg/kg/d) of berberine was orally administered to the rats for 4 weeks. After 4 weeks, changes of body weight, blood lipid and glucose were detected, and the expression levels of Nrf2 and HO-1 in retinal tissues were evaluated by immunohistochemistry and Western blot. Results: Four weeks of berberine intervention decreased blood glucose to below 16 mmol/L. Total Cholesterol (TC), Triglyceride (TG), and Low-Density Lipoprotein cholesterol (LDL) was decreased significantly, while High-Density Lipoprotein cholesterol (HDL) was increased significantly than that in the model group (P<0.05). The expressions of Nrf2 and HO-1 were also decreased in retinal cells after berberine treatment compared with those in the model group. Conclusion: Berberine can reduce blood glucose level in diabetic rats, improve blood lipid and decrease retinal vascular injury, suggesting it may be associated with the reduced expressions of Nrf2/HO-1.
出版者	ALLIED ACAD
出版地	LONDON
ISSN	0970-938X
EISSN	0976-1683
卷号	28 期号:9 页码:3860-3864
页数	5
WOS类目	Engineering, Biomedical ; Medicine, Research & Experimental
WOS研究方向	Engineering ; Research & Experimental Medicine
WOS记录号	WOS:000403460100013
收录类别	SCIE ; SCOPUS
URL	查看原文
SCOPUSEID	2-s2.0-85019653914
通讯作者地址	[Wang, Lingyun]Outpatient Department,The First Affiliated Hospital of Wenzhou Medical University,China
Scopus学科分类	Biochemistry, Genetics and Molecular Biology (all)
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/15385
专题	附属第一医院_门诊部
通讯作者	Wang, Lingyun
作者单位	1.Department of Endocrinology,Wenzhou Central Hospital,Wenzhou,325000,China; 2.Outpatient Department,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
推荐引用方式 GB/T 7714	Tao, Kai,Chen, Jinghai,Wang, Lingyun. Effects of berberine on the expressions of NRF2 and HO-1 in endothelial cells of diabetic rat[J]. BIOMEDICAL RESEARCH-INDIA,2017,28(9):3860-3864.
APA	Tao, Kai, Chen, Jinghai, & Wang, Lingyun. (2017). Effects of berberine on the expressions of NRF2 and HO-1 in endothelial cells of diabetic rat. BIOMEDICAL RESEARCH-INDIA, 28(9), 3860-3864.
MLA	Tao, Kai,et al."Effects of berberine on the expressions of NRF2 and HO-1 in endothelial cells of diabetic rat".BIOMEDICAL RESEARCH-INDIA 28.9(2017):3860-3864.