Effect of Probiotic Fungi against Cognitive Impairment in Mice via Regulation of the Fungal Microbiota-Gut-Brain Axis

doi:10.1021/acs.jafc.2c03142

科研成果详情

题名	Effect of Probiotic Fungi against Cognitive Impairment in Mice via Regulation of the Fungal Microbiota-Gut-Brain Axis
作者	Ye, Tao 1; Yuan, Shushu2; Kong, Yu2; Yang, Huiqun2; Wei, Hongming1; Zhang, Yuhe2; Jin, Hangqi2; Yu, Qingxia2; Liu, Jiaming2; Chen, Songfang 3; Sun, Jing 1
发表日期	2022-07-14
发表期刊	Journal of Agricultural and Food Chemistry 影响因子和分区
语种	英语
原始文献类型	Journal article (JA)
关键词	Chemical activation Fungi Mammals Neurodegenerative diseases Proteins Alzheimers disease Cognitive impairment Fungal microbiota Microbiotas Microglia Neuroinflammation Probiotics Saccharomyces Saccharomyces boulardii Toll-like receptors
其他关键词	ALZHEIMERS-DISEASE ; SACCHAROMYCES-BOULARDII ; MECHANISMS ; STRAINS ; PATHWAY ; BARRIER
摘要	The fungal microbiota may be involved in the regulation of cognition and behavior, while the role of probiotic fungi against cognitive impairment is unclear. Here, we explored the idea that probiotic Saccharomyces boulardii could participate in the regulation of microglia-induced neuroinflammation in Alzheimer's disease (AD) model mice. Cognitive deficits, deposits of amyloid-β (Aβ) and phosphorylation of tau, synaptic plasticity, microglia activation, and neuroinflammatory reactions were observed. The expression levels of Toll-like receptors (TLRs) pathway-related proteins were detected. Meanwhile, intestinal barrier integrity and fungal microbiota composition were evaluated. Our results showed fungal microbiota dysbiosis in APP/PS1 mice, which might result in the neuroinflammation of AD. The increased levels of interleukin (IL)-6, IL-1β, and cluster of differentiation 11b (CD11b) were observed in APP/PS1 mice, which were associated with activation of microglia, indicative of a broader recognition of neuroinflammation mediated by fungal microbiota compared to hitherto appreciated. Probiotic S. boulardii treatment improved dysbiosis, alleviated the neuroinflammation as well as synaptic injury, and ultimately improved cognitive impairment. Moreover, S. boulardii therapy could inhibit microglia activation and the TLRs pathway, which were reversed by antifungal treatment. These findings revealed that S. boulardii actively participated in regulating the TLRs pathway to inhibit the neuroinflammation via the gut-brain axis. © 2022 American Chemical Society.
资助项目	Natural Science Foundation of Zhejiang Province [LY22H090006]
出版者	American Chemical Society
出版地	WASHINGTON
ISSN	0021-8561
EISSN	1520-5118
卷号	70 期号:29 页码:9026-9038
DOI	10.1021/acs.jafc.2c03142
页数	13
WOS类目	Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
WOS研究方向	Agriculture ; Chemistry ; Food Science & Technology
WOS记录号	WOS:000830042100001
收录类别	EI ; SCIE ; PUBMED ; SCOPUS
EI入藏号	20223212553574
EI主题词	Probiotics
EI分类号	461.2 Biological Materials and Tissue Engineering ; 461.6 Medicine and Pharmacology ; 461.9 Biology ; 802.2 Chemical Reactions ; 804 Chemical Products Generally ; 804.1 Organic Compounds
URL	查看原文
PubMed ID	35833673
SCOPUSEID	2-s2.0-85135380612
通讯作者地址	[Sun, Jing]Department of Geriatrics,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,325027,China ; [Liu, Jiaming]Department of Preventive Medicine,School of Public Health and Management,Wenzhou Medical University,Zhejiang,Wenzhou,325035,China ; [Chen, Songfang]Department of Neurology,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,325027,China
Scopus学科分类	Chemistry (all);Agricultural and Biological Sciences (all)
TOP期刊	TOP期刊
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/153475
专题	第二临床医学院、附属第二医院、育英儿童医院附属第二医院公共卫生学院_预防医学系
通讯作者	Liu, Jiaming; Chen, Songfang; Sun, Jing
作者单位	1.Department of Geriatrics,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,325027,China; 2.Department of Preventive Medicine,School of Public Health and Management,Wenzhou Medical University,Zhejiang,Wenzhou,325035,China; 3.Department of Neurology,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,325027,China
第一作者单位	第二临床医学院，附属第二医院、育英儿童医院; 附属第二医院
通讯作者单位	第二临床医学院，附属第二医院、育英儿童医院; 附属第二医院; 公共卫生学院; 预防医学系
第一作者的第一单位	第二临床医学院，附属第二医院、育英儿童医院
推荐引用方式 GB/T 7714	Ye, Tao,Yuan, Shushu,Kong, Yu,et al. Effect of Probiotic Fungi against Cognitive Impairment in Mice via Regulation of the Fungal Microbiota-Gut-Brain Axis[J]. Journal of Agricultural and Food Chemistry,2022,70(29):9026-9038.
APA	Ye, Tao., Yuan, Shushu., Kong, Yu., Yang, Huiqun., Wei, Hongming., ... & Sun, Jing. (2022). Effect of Probiotic Fungi against Cognitive Impairment in Mice via Regulation of the Fungal Microbiota-Gut-Brain Axis. Journal of Agricultural and Food Chemistry, 70(29), 9026-9038.
MLA	Ye, Tao,et al."Effect of Probiotic Fungi against Cognitive Impairment in Mice via Regulation of the Fungal Microbiota-Gut-Brain Axis".Journal of Agricultural and Food Chemistry 70.29(2022):9026-9038.