Decreased Vessel Density in Retinal Capillary Plexus and Thinner Ganglion Cell Complex Associated With Cognitive Impairment

doi:10.3389/fnagi.2022.872466

科研成果详情

题名	Decreased Vessel Density in Retinal Capillary Plexus and Thinner Ganglion Cell Complex Associated With Cognitive Impairment
作者	Yang, Kai1; Cui, Lele1; Chen, Xueyu 2; Yang, Chuang3; Zheng, Jingwei1; Zhu, Xiaoxuan1; Xiao, Yunfan1; Su, Binbin1; Li, Chunmei1; Shi, Keai1; Lu, Fan1; Qu, Jia1; Li, Ming1
发表日期	2022-04-26
发表期刊	FRONTIERS IN AGING NEUROSCIENCE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	cognitive impairment optical coherence tomography angiography retinal capillary plexus ganglion cell complex imaging
其他关键词	OPTICAL COHERENCE TOMOGRAPHY ; NERVE-FIBER LAYER ; ALZHEIMERS-DISEASE ; BIOMARKERS ; ANGIOGRAPHY ; DEFINITION ; OBJECTIVES ; DEMENTIA ; DESIGN ; COHORT
摘要	BackgroundTo determine the association of the retinal capillary plexus (RCP) and ganglion cell complex (GCC) with cognitive impairment using optical coherence tomography angiography (OCTA). MethodsA cross-sectional, community-based study utilizing data from the participants enrolled between August 2019 and January 2020 in the Jidong Eye Cohort Study. We assessed the vessel density in RCP and GCC thickness using OCTA, and cognitive testing using the Montreal Cognitive Assessment (MoCA). Cognitive impairment in this study was defined as MoCA score < 24. We used multivariable analysis to evaluate the association of RCP and GCC with cognitive impairment after adjusting for confounders. ResultsThis study analyzed 1555 participants. The mean age of participants was 52.3 (8.4) years, and 861 (55.4%) were women. Cognitive impairment was observed in 268 (17.2%) participants. The adjusted odds ratio (OR) with 95% confidence interval (95% CI) for parafovea vessel density in the deep RCP with cognitive impairment was 1.20 (1.03-1.39). For vessel area and length density surrounding foveal avascular zone with cognitive impairment, the ORs with 95% CIs were 1.23 (1.07-1.41) and 1.30 (1.13-1.49), respectively. For thickness in the superior GCC with cognitive impairment, the OR with 95% CI was 1.16 (1.01-1.32). ConclusionLower vessel density in the RCP and thinner GCC were associated with cognitive impairment. Our results suggest that alterations in the RCP and GCC could provide further evidence when assessing the cognitive function and may even be potentially useful biomarkers in the detection of cognitive impairment.
资助项目	National Natural Science Foundation of China [81900903]; Zhejiang Provincial Natural Science Foundation of China [LY22H120007]; National Key R&D Program of China [2020YFC2008200, 2019YFC0840708]; Wenzhou Science and Technology Program [Y20210984]; Medical and Health Science and Technology Program of Zhejiang Province [2017KY113, 2018KY543]
出版者	FRONTIERS MEDIA SA
出版地	LAUSANNE
ISSN	1663-4365
卷号	14 页码:872466
DOI	10.3389/fnagi.2022.872466
页数	11
WOS类目	Geriatrics & Gerontology ; Neurosciences
WOS研究方向	Geriatrics & Gerontology ; Neurosciences & Neurology
WOS记录号	WOS:000795113800001
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	35557840
SCOPUSEID	2-s2.0-85132620781
通讯作者地址	[Qu, Jia]Eye Hospital,School of Ophthalmology and Optometry,National Clinical Research Center for Ocular Diseases,Wenzhou Medical University,Wenzhou,China ; [Li, Ming]Eye Hospital,School of Ophthalmology and Optometry,National Clinical Research Center for Ocular Diseases,Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Aging;Cognitive Neuroscience
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/148535
专题	眼视光学院（生物医学工程学院）、附属眼视光医院附属第一医院_精神卫生科
通讯作者	Qu, Jia; Li, Ming
作者单位	1.Eye Hospital,School of Ophthalmology and Optometry,National Clinical Research Center for Ocular Diseases,Wenzhou Medical University,Wenzhou,China; 2.Department of Biostatistics,School of Public Health,Cheeloo College of Medicine,Shandong University,Jinan,China; 3.Department of Mental Health,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
第一作者单位	眼视光学院（生物医学工程学院）、附属眼视光医院
通讯作者单位	眼视光学院（生物医学工程学院）、附属眼视光医院
第一作者的第一单位	眼视光学院（生物医学工程学院）、附属眼视光医院
推荐引用方式 GB/T 7714	Yang, Kai,Cui, Lele,Chen, Xueyu,et al. Decreased Vessel Density in Retinal Capillary Plexus and Thinner Ganglion Cell Complex Associated With Cognitive Impairment[J]. FRONTIERS IN AGING NEUROSCIENCE,2022,14:872466.
APA	Yang, Kai., Cui, Lele., Chen, Xueyu., Yang, Chuang., Zheng, Jingwei., ... & Li, Ming. (2022). Decreased Vessel Density in Retinal Capillary Plexus and Thinner Ganglion Cell Complex Associated With Cognitive Impairment. FRONTIERS IN AGING NEUROSCIENCE, 14, 872466.
MLA	Yang, Kai,et al."Decreased Vessel Density in Retinal Capillary Plexus and Thinner Ganglion Cell Complex Associated With Cognitive Impairment".FRONTIERS IN AGING NEUROSCIENCE 14(2022):872466.