Serum cholesterol positively associated with oxidative DNA damage: a propensity score-matched analysis

doi:10.1080/10715762.2019.1595613

科研成果详情

题名	Serum cholesterol positively associated with oxidative DNA damage: a propensity score-matched analysis
作者	Wei, Ya-Ping 1,2; Jia, Chao-Nan 1,2; Lan, Yuan 3; Hou, Xiang-Qing 1,2; Zuo, Jing-Jing 3; Cui, Huan1; Guan, Xiao-Ju1,2; Wang, Yi1,2; Mao, Guang-Yun1,2,3,4
发表日期	2019-04-03
发表期刊	FREE RADICAL RESEARCH 影响因子和分区
语种	英语
原始文献类型	Article
关键词	8-hydroxy-2 '-deoxyguanosine oxidative DNA damage propensity score matching serum total cholesterol
其他关键词	STRESS ; CHILDREN ; 8-OHDG ; CANCER ; LIVER ; ELISA ; RISK
摘要	Oxidative DNA damage pathogenically links to some major diseases. This study aimed to comprehensively assess the association between serum total cholesterol (TC) and oxidative DNA damage based on propensity score matching (PSM) method. A total of 407 participants chronically exposed to arsenic via drinking water from China were enrolled. Oxidative DNA damage was determined with urinary 8-hydroxy-2 '-deoxyguanosine (8-OHdG). Serum TC was classified into favourable TC (FTC, TC <5.18mmol/L) and unfavourable TC (NFTC, TC >= 5.18mmol/L) categories. Multivariable generalised linear regression model was applied to examine the association. Of 407 participants, 125 pairs with FTC and NFTC subjects were matched using PSM. Urinary 8-OHdG/creatinine levels in NFTC were significantly higher than those in FTC category (p=.002). As compared to the counterparts, additional adjusted log-transformed 8-OHdG/creatinine increase was observed in NFTC for unmatched (beta=0.12, p=.052) and matched (beta=0.17, p<.001) participants, respectively. We also detected obviously increased log-transformed urinary 8-OHdG/creatinine with per interquartile range raise of serum TC either in unmatched (beta=0.10, p=.007) or matched (beta=0.16, p=.003) subjects. In conclusion, serum TC was independently associated with oxidative DNA damage. Our findings provided new insights on the health promotion of lipids relevant to the early warning of diseases due to oxidative DNA damage.
资助项目	science and technology plan project of Wenzhou, China [2018Y1248] ; research of basic public welfare plan project of Zhejiang province of China [LGF19H260011] ; major project of the eye hospital of Wenzhou medical university [YNZD201602] ; [KYQD170301]
出版者	TAYLOR & FRANCIS LTD
出版地	ABINGDON
ISSN	1071-5762
EISSN	1029-2470
卷号	53 期号:4 页码:411-417
DOI	10.1080/10715762.2019.1595613
页数	7
WOS类目	Biochemistry & Molecular Biology
WOS研究方向	Biochemistry & Molecular Biology
WOS记录号	WOS:000476929600006
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	30885010
SCOPUSEID	2-s2.0-85063929962
通讯作者地址	[Mao, Guang-Yun]School of Public Health and Management,Wenzhou Medical University,Chashan University town,Ouhai district, Room 7A321,Wenzhou,China
Scopus学科分类	Biochemistry
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/14844
专题	公共卫生学院_预防医学系公共卫生学院眼视光学院（生物医学工程学院）、附属眼视光医院眼视光学院（生物医学工程学院）、附属眼视光医院_临床与流行病学研究中心
通讯作者	Mao, Guang-Yun
作者单位	1.Department of Preventive Medicine,School of Public Health and Management,Wenzhou Medical University,Wenzhou,China; 2.Center on Evidence-Based Medicine & Clinical Epidemiological Research,School of Public Health,Wenzhou Medical University,Wenzhou,China; 3.School of Ophthalmology & Optometry,Wenzhou Medical University,Wenzhou,China; 4.Center on Clinical Research,the Affiliated Eye Hospital of Wenzhou Medical University,Wenzhou,China
第一作者单位	预防医学系; 公共卫生学院; 临床与流行病学研究中心
通讯作者单位	公共卫生学院
第一作者的第一单位	预防医学系
推荐引用方式 GB/T 7714	Wei, Ya-Ping,Jia, Chao-Nan,Lan, Yuan,et al. Serum cholesterol positively associated with oxidative DNA damage: a propensity score-matched analysis[J]. FREE RADICAL RESEARCH,2019,53(4):411-417.
APA	Wei, Ya-Ping., Jia, Chao-Nan., Lan, Yuan., Hou, Xiang-Qing., Zuo, Jing-Jing., ... & Mao, Guang-Yun. (2019). Serum cholesterol positively associated with oxidative DNA damage: a propensity score-matched analysis. FREE RADICAL RESEARCH, 53(4), 411-417.
MLA	Wei, Ya-Ping,et al."Serum cholesterol positively associated with oxidative DNA damage: a propensity score-matched analysis".FREE RADICAL RESEARCH 53.4(2019):411-417.