Three Nutritional Indices Are Effective Predictors of Mortality in Patients With Type 2 Diabetes and Foot Ulcers

doi:10.3389/fnut.2022.851274

科研成果详情

题名	Three Nutritional Indices Are Effective Predictors of Mortality in Patients With Type 2 Diabetes and Foot Ulcers
作者	Hong, Jing1; Huang, Qi-Qi 2; Liu, Wen-Yue1; Hu, Xiang1; Jiang, Fei-Fei1; Xu, Ze-Ru 1; Shen, Fei-Xia1; Zhu, Hong1
发表日期	2022-03-15
发表期刊	FRONTIERS IN NUTRITION 影响因子和分区
语种	英语
原始文献类型	Article
关键词	diabetes mellitus foot ulcer malnutrition mortality nutrition assessment
其他关键词	ALL-CAUSE MORTALITY ; ASSOCIATION ; IMPACT ; OUTCOMES ; DISEASE
摘要	IntroductionMalnutrition has been associated with mortality in various diseases. This retrospective cohort study aimed to investigate the relationship between three nutritional indices and all-cause mortality in patients with diabetic foot ulcers (DFUs). Materials and MethodsA total of 771 patients diagnosed with DFUs in the First Affiliated Hospital of Wenzhou Medical University from 2015 to 2019 were included in this retrospective cohort study. Patients were classified as high nutritional risk groups or low nutritional risk groups according to the optimal cut-off values of the geriatric nutritional risk index (GNRI), prognostic nutritional index (PNI), and controlling nutritional status (CONUT), respectively. The associations of three nutritional indices with all-cause mortality were evaluated by multivariable Cox regression analyses. ResultsLog-rank tests indicated that patients with high nutritional risk had lower overall survival rates (all p < 0.001). The multivariable Cox regression revealed that low GNRI (adjusted HR 2.01, 95% CI: 1.37-2.96, P < 0.001), low PNI (adjusted HR 2.04, 95% CI: 1.29-3.23, P = 0.002) and high CONUT (adjusted HRs 1.54, 95% CI: 1.07-2.23, P = 0.021) were independently associated with high all-cause mortality. In subgroup analyses, only GNRI predicted higher all-cause mortality in patients with severe DFUs, while all of the three indices persisted as independent prognostic factors in patients with no severe DFUs. DiscussionThe present study demonstrated that three nutritional indices were effective predictors of all-cause mortality in patients with DFUs. Routine screening for malnutrition using any of the three nutritional indices might be a simple and effective way to identify high-risk patients with DFUs. GNRI can be used as an independent prognostic indicator in patients with severe DFUs.
资助项目	Wenzhou Medical University[KYYW202015];National Natural Science Foundation of China[81900737];
出版者	FRONTIERS MEDIA SA
出版地	LAUSANNE
ISSN	2296-861X
卷号	9 页码:851274
DOI	10.3389/fnut.2022.851274
页数	8
WOS类目	Nutrition & Dietetics
WOS研究方向	Nutrition & Dietetics
WOS记录号	WOS:000777481000001
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	35369056
SCOPUSEID	2-s2.0-85127484099
通讯作者地址	[Zhu, Hong]Department of Endocrinology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Food Science;Endocrinology, Diabetes and Metabolism;Nutrition and Dietetics
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/148432
专题	附属第一医院_内分泌科附属第一医院_营养科
通讯作者	Zhu, Hong
作者单位	1.Department of Endocrinology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.Department of Nutrition,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Hong, Jing,Huang, Qi-Qi,Liu, Wen-Yue,et al. Three Nutritional Indices Are Effective Predictors of Mortality in Patients With Type 2 Diabetes and Foot Ulcers[J]. FRONTIERS IN NUTRITION,2022,9:851274.
APA	Hong, Jing., Huang, Qi-Qi., Liu, Wen-Yue., Hu, Xiang., Jiang, Fei-Fei., ... & Zhu, Hong. (2022). Three Nutritional Indices Are Effective Predictors of Mortality in Patients With Type 2 Diabetes and Foot Ulcers. FRONTIERS IN NUTRITION, 9, 851274.
MLA	Hong, Jing,et al."Three Nutritional Indices Are Effective Predictors of Mortality in Patients With Type 2 Diabetes and Foot Ulcers".FRONTIERS IN NUTRITION 9(2022):851274.