Differential Influence of the COVID-19 Pandemic on Mechanical Thrombectomy and Bridging Therapy for Acute Ischemic Stroke

doi:10.3389/fneur.2022.852423

科研成果详情

题名	Differential Influence of the COVID-19 Pandemic on Mechanical Thrombectomy and Bridging Therapy for Acute Ischemic Stroke
作者	Geng, Dandan1; Xu, Xueqian 1; Luan, Xiaoqian1; Qiu, Linan 1; Chen, Liuzhu 1; Chen, Jiahao 1; Wu, Beilan1; Xu, Minjie2; Ergashev, Akmal 3; Tang, Wenjie 4; Li, Jia 1
发表日期	2022-03-22
发表期刊	FRONTIERS IN NEUROLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	COVID-19 acute ischemic stroke mechanical thrombectomy bridging thrombolysis functional prognosis
其他关键词	THROMBOLYSIS ; PERFUSION ; CT
摘要	BackgroundThe coronavirus disease 2019 (COVID-19) pandemic is having a dramatic impact on acute stroke care. Its effects may accompany stroke care for a long time. We compared the treatment, short-term and long-term functional outcomes of patients with AIS from 2019 to 2020. Our objective was to evaluate the effect of COVID-19 epidemic on mechanical thrombectomy (MT) in patients in our hospital. MethodsWe collected information on subjects treated with MT in 2019-2020, including age, sex, time from the onset to arterial sheath insertion, time from the onset to recanalization, the rate of lung infection and hemorrhagic transformation, modified Rankin scale (mRS), NHISS, and ASPECTS. ResultsThe number of patients with MT decreased significantly by 26.6% in 2020 (p = 0.025). The pretreatment ASPECTS score for 2020 was significantly higher than 2019 (p = 0.004). Besides, the patients were more likely to develop lung infection (65 vs. 54.1%, p = 0.042) and had a higher risk of hemorrhagic transformation (47.4% vs. 30.4%, p = 0.005) in 2019. The discharged mRS reflected the worse short-term functional prognosis of patients with MT in 2019 (66 vs. 44.9%, p = 0.046). In the subgroup analysis of bridging thrombolysis (BT), more patients with BT are expected to have a poor short-term functional prognosis in 2020, according to the discharged mRS (62.5 vs. 37.5%, p = 0.024). However, there was no difference in mRS at 180 days between the two groups (p = 0.094). ConclusionFor patients with MT, both short- and long-term functional outcomes were not significantly affected due to the mild condition of patients admitted to hospital in 2020. For patients with BT, the COVID-19 pandemic has prolonged the green channel time of stroke, leading to a poor short-term functional prognosis of patients with stroke in the pandemic period. There was no difference in the effectiveness of direct MT and BT during the COVID-19 pandemic.
出版者	FRONTIERS MEDIA SA
出版地	LAUSANNE
ISSN	1664-2295
卷号	13 页码:852423
DOI	10.3389/fneur.2022.852423
页数	8
WOS类目	Clinical Neurology ; Neurosciences
WOS研究方向	Neurosciences & Neurology
WOS记录号	WOS:000779559500001
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	35392636
SCOPUSEID	2-s2.0-85128169671
通讯作者地址	[Li, Jia]Department of Neurology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China ; [Tang, Wenjie]The First School of Clinical Medicine,Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Neurology;Neurology (clinical)
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/148431
专题	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科第一临床医学院（信息与工程学院）、附属第一医院附属第一医院精神医学学院
通讯作者	Tang, Wenjie; Li, Jia
作者单位	1.Department of Neurology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.Wenzhou Medical University School of Mental Health,Wenzhou,China; 3.Department of General Surgery,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 4.The First School of Clinical Medicine,Wenzhou Medical University,Wenzhou,China
第一作者单位	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科
通讯作者单位	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科
推荐引用方式 GB/T 7714	Geng, Dandan,Xu, Xueqian,Luan, Xiaoqian,et al. Differential Influence of the COVID-19 Pandemic on Mechanical Thrombectomy and Bridging Therapy for Acute Ischemic Stroke[J]. FRONTIERS IN NEUROLOGY,2022,13:852423.
APA	Geng, Dandan., Xu, Xueqian., Luan, Xiaoqian., Qiu, Linan., Chen, Liuzhu., ... & Li, Jia. (2022). Differential Influence of the COVID-19 Pandemic on Mechanical Thrombectomy and Bridging Therapy for Acute Ischemic Stroke. FRONTIERS IN NEUROLOGY, 13, 852423.
MLA	Geng, Dandan,et al."Differential Influence of the COVID-19 Pandemic on Mechanical Thrombectomy and Bridging Therapy for Acute Ischemic Stroke".FRONTIERS IN NEUROLOGY 13(2022):852423.