科研成果详情

题名Delivery of Basic Fibroblast Growth Factor Through an In Situ Forming Smart Hydrogel Activates Autophagy in Schwann Cells and Improves Facial Nerves Generation via the PAK-1 Signaling Pathway
作者
发表日期2022-04-01
发表期刊FRONTIERS IN PHARMACOLOGY   影响因子和分区
语种英语
原始文献类型Article
关键词facial nerve injury autophagy Pak1 in situ forming hydrogel basic fibroblast growth factor
其他关键词WALLERIAN DEGENERATION ; REGENERATION ; P21-ACTIVATED-KINASE-1 ; PROLIFERATION ; CLEARANCE ; ACTIN
摘要

Although studies have shown that basic fibroblast growth factor (bFGF) can activate autophagy and promote peripheral nerve repair, the role and the molecular mechanism of action of bFGF in the facial nerve are not clear. In this study, a thermosensitive in situ forming poloxamer hydrogel was used as a vehicle to deliver bFGF for treating facial nerve injury (FNI) in the rat model. Using H&E and Masson's staining, we found that bFGF hydrogel can promote the functional recovery and regeneration of the facial nerve. Furthermore, studies on the mechanism showed that bFGF can promote FNI recovery by promoting autophagy and inhibiting apoptosis. Additionally, this study demonstrated that the role of hydrogel binding bFGF in nerve repair was mediated through the activation of the PAK1 signaling pathway in Schwann cells (SCs). These results indicated that poloxamer thermosensitive hydrogel loaded with bFGF can significantly restore the morphology and function of the injured facial nerve by promoting autophagy and inhibiting apoptosis by activating the PAK1 pathway, which can provide a promising strategy for FNI recovery.

资助项目National Natural Science Foundation of China [81972150, 81802251, 81772450] ; Zhejiang Provincial Natural Science Foundation of China [LR18H50001] ; Wenzhou Science and Technology Innovation Project [ZY2020023, ZY2020026] ; CAMS Innovation Fund for Medical Sciences [2019-I2M-5-028]
出版者FRONTIERS MEDIA SA
出版地LAUSANNE
ISSN1663-9812
EISSN1663-9812
卷号13页码:778680
DOI10.3389/fphar.2022.778680
页数14
WOS类目Pharmacology & Pharmacy
WOS研究方向Pharmacology & Pharmacy
WOS记录号WOS:000787999800001
收录类别SCIE ; SCOPUS ; PUBMED
URL查看原文
PubMed ID35431972
SCOPUSEID2-s2.0-85128458057
通讯作者地址[Ni, Liyan]Department of Otorhinolaryngology,The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Wenzhou,China ; [Xiao, Jian]Key Laboratory of Biotechnology and Pharmaceutical Engineering,School of Pharmaceutical Sciences,Cixi Biomedical Research Institute,Wenzhou Medical University,Wenzhou,China ; [Zhang, Hongyu]Key Laboratory of Biotechnology and Pharmaceutical Engineering,School of Pharmaceutical Sciences,Cixi Biomedical Research Institute,Wenzhou Medical University,Wenzhou,China
Scopus学科分类Pharmacology;Pharmacology (medical)
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/148430
专题第二临床医学院、附属第二医院、育英儿童医院
药学院(分析测试中心)
附属第一医院_烧伤科
研究生工作部(研究生院)
通讯作者Xiao, Jian; Zhang, Hongyu; Ni, Liyan
作者单位
1.Department of Otorhinolaryngology,The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Wenzhou,China;
2.Key Laboratory of Biotechnology and Pharmaceutical Engineering,School of Pharmaceutical Sciences,Cixi Biomedical Research Institute,Wenzhou Medical University,Wenzhou,China;
3.Department of Burn,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
第一作者单位第二临床医学院,附属第二医院、育英儿童医院;  附属第二医院;  药学院(分析测试中心)
通讯作者单位第二临床医学院,附属第二医院、育英儿童医院;  附属第二医院;  药学院(分析测试中心)
第一作者的第一单位第二临床医学院,附属第二医院、育英儿童医院
推荐引用方式
GB/T 7714
Hu, Binbin,Zhang, Hanbo,Xu, Menglu,et al. Delivery of Basic Fibroblast Growth Factor Through an In Situ Forming Smart Hydrogel Activates Autophagy in Schwann Cells and Improves Facial Nerves Generation via the PAK-1 Signaling Pathway[J]. FRONTIERS IN PHARMACOLOGY,2022,13:778680.
APA Hu, Binbin., Zhang, Hanbo., Xu, Menglu., Li, Lei., Wu, Man., ... & Ni, Liyan. (2022). Delivery of Basic Fibroblast Growth Factor Through an In Situ Forming Smart Hydrogel Activates Autophagy in Schwann Cells and Improves Facial Nerves Generation via the PAK-1 Signaling Pathway. FRONTIERS IN PHARMACOLOGY, 13, 778680.
MLA Hu, Binbin,et al."Delivery of Basic Fibroblast Growth Factor Through an In Situ Forming Smart Hydrogel Activates Autophagy in Schwann Cells and Improves Facial Nerves Generation via the PAK-1 Signaling Pathway".FRONTIERS IN PHARMACOLOGY 13(2022):778680.

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