Biomechanical Effects of tPRK, FS-LASIK, and SMILE on the Cornea

doi:10.3389/fbioe.2022.834270

科研成果详情

题名	Biomechanical Effects of tPRK, FS-LASIK, and SMILE on the Cornea
作者	Xin, Yue 1; Lopes, Bernardo T.2; Wang, JunJie1,3; Wu, Jie 1; Zhu, ManMan1; Jiang, MuChen1; Miao, YuanYuan 1; Lin, HuiNi 4; Cao, Si 5; Zheng, XiaoBo1,3; Eliasy, Ashkan 2; Chen, ShiHao1,3; Wang, QinMei1,3; Ye, YuFeng1; Bao, FangJun 1,3; Elsheikh, Ahmed 2,6,7
发表日期	2022-03-31
发表期刊	FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	biomechanical response in-vivo tPRK FS-LASIK SMILE
其他关键词	INCISION LENTICULE EXTRACTION ; TRANSEPITHELIAL PHOTOREFRACTIVE KERATECTOMY ; CORRECTED INTRAOCULAR-PRESSURE ; IN-SITU KERATOMILEUSIS ; LASER-ASSISTED LASIK ; RESPONSE PARAMETERS ; BILATERAL ECTASIA ; CROSS-LINKING ; TISSUE ; FLAP
摘要	Purpose: The objective of this study is to evaluate the in vivo corneal biomechanical response to three laser refractive surgeries.Methods: Two hundred and twenty-seven patients who submitted to transepithelial photorefractive keratectomy (tPRK), femtosecond laser-assisted in-situ keratomileusis (FS-LASIK), or small-incision lenticule extraction (SMILE) were included in this study. All cases were examined with the Corvis ST preoperatively (up to 3 months) and postoperatively at 1, 3, and 6 months, and the differences in the main device parameters were assessed. The three groups were matched in age, gender ratio, corneal thickness, refractive error corrections, optical zone diameter, and intraocular pressure. They were also matched in the preoperative biomechanical metrics provided by the Corvis ST including stiffness parameter at first applanation (SP-A1), integrated inverse radius (IIR), deformation amplitude (DA), and deformation amplitude 2 mm away from apex and the apical deformation (DARatio2mm).Results: The results demonstrated a significant decrease post-operation in SP-A1 and significant increases in IIR, DA, and DARatio2mm (p < 0.05), all of which indicated reductions in overall corneal stiffness. Inter-procedure comparisons provided evidence that the smallest overall stiffness reduction was in the tPRK group, followed by the SMILE, and then the FS-LASIK group (p < 0.05). These results remained valid after correction for the change in CCT between pre and 6 months post-operation and for the percentage tissue altered. In all three surgery groups, higher degrees of refractive correction resulted in larger overall stiffness losses based on most of the biomechanical metrics.Conclusion: The corneal biomechanical response to the three surgery procedures varied significantly. With similar corneal thickness loss, the reductions in overall corneal stiffness were the highest in FS-LASIK and the lowest in tPRK.
资助项目	National Natural Science Foundation of China [82001924, 31771020]; Zhejiang Provincial Natural Science Foundation of China [LY20H120001, LQ20A020008]; Projects of Medical and Health Technology Development Program in Zhejiang Province [2019RC056, 2018KY541]; Science and Technology Plan Project of Wenzhou Science and Technology Bureau [Y2020354, Y20180172, Y20170198, Y20170792]; General Projects of Department of Education of Zhejiang Province [Y201839651]
出版者	FRONTIERS MEDIA SA
出版地	LAUSANNE
ISSN	2296-4185
EISSN	2296-4185
卷号	10 页码:834270
DOI	10.3389/fbioe.2022.834270
页数	9
WOS类目	Biotechnology & Applied Microbiology ; Multidisciplinary Sciences
WOS研究方向	Biotechnology & Applied Microbiology ; Science & Technology - Other Topics
WOS记录号	WOS:000789126300001
收录类别	SCIE ; EI ; SCOPUS ; PUBMED
EI入藏号	20221712009315
EI主题词	Surgery
EI分类号	461.3 Biomechanics, Bionics and Biomimetics ; 461.6 Medicine and Pharmacology ; 951 Materials Science
URL	查看原文
PubMed ID	35433653
SCOPUSEID	2-s2.0-85128475551
通讯作者地址	[Chen, ShiHao]Eye Hospital,Wenzhou Medical University,Wenzhou,China ; [Ye, YuFeng]Eye Hospital,Wenzhou Medical University,Wenzhou,China ; [Bao, FangJun]Eye Hospital,Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Biotechnology;Bioengineering;Histology;Biomedical Engineering
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/148231
专题	眼视光学院（生物医学工程学院）、附属眼视光医院温州医科大学
通讯作者	Chen, ShiHao; Ye, YuFeng; Bao, FangJun
作者单位	1.Eye Hospital,Wenzhou Medical University,Wenzhou,China; 2.School of Engineering,University of Liverpool,Liverpool,United Kingdom; 3.The Institute of Ocular Biomechanics,Wenzhou Medical University,Wenzhou,China; 4.STU-CUHK Joint Shantou International Eye Center,Shantou,China; 5.Wuhan Puren Hospital,Wuhan,China; 6.National Institute for Health Research,NIHR) Biomedical Research Centre for Ophthalmology,Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology,London,United Kingdom; 7.Beijing Advanced Innovation Center for Biomedical Engineering,Beihang University,Beijing,China
第一作者单位	眼视光学院（生物医学工程学院）、附属眼视光医院
通讯作者单位	眼视光学院（生物医学工程学院）、附属眼视光医院
第一作者的第一单位	眼视光学院（生物医学工程学院）、附属眼视光医院
推荐引用方式 GB/T 7714	Xin, Yue,Lopes, Bernardo T.,Wang, JunJie,et al. Biomechanical Effects of tPRK, FS-LASIK, and SMILE on the Cornea[J]. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY,2022,10:834270.
APA	Xin, Yue., Lopes, Bernardo T.., Wang, JunJie., Wu, Jie., Zhu, ManMan., ... & Elsheikh, Ahmed. (2022). Biomechanical Effects of tPRK, FS-LASIK, and SMILE on the Cornea. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 10, 834270.
MLA	Xin, Yue,et al."Biomechanical Effects of tPRK, FS-LASIK, and SMILE on the Cornea".FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 10(2022):834270.