Biofabricated macrophage and fibroblast membranes synergistically promote skin wound healing

doi:10.1002/btm2.10344

科研成果详情

题名	Biofabricated macrophage and fibroblast membranes synergistically promote skin wound healing
作者	Wang, Dongqing 1; Chen, Heying 1; Lei, Li 1; Chen, Jun 2; Gao, Jimin3; Liu, Jiahe 1; Li, Qianyin 1; Xie, Yajun 1; Hu, Yi 2; Ni, Yilu 1
发表日期	2022-09
发表期刊	BIOENGINEERING & TRANSLATIONAL MEDICINE 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	cytomembrane fibroblast macrophage wound healing
其他关键词	DENDRITIC CELLS ; SINGLE-CELL ; IN-VIVO ; REPAIR ; ACTIVATION
摘要	Effective skin wound healing is a complex process involving anti-inflammation, fibrosis, matrix reconstruction, and angiogenesis. This work aimed to integrate the macrophage-mediated anti-inflammation and fibroblast-assisted matrix reconstruction for enhanced skin wound healing. Herein, we utilized the cytomembranes derived from repolarized M2 macrophages and fibroblasts to prepare the natural biologics. Results showed that the inflammatory M1 macrophages were repolarized to M2 phenotype by the M2 macrophage cytomembranes. As a consequence, the cytomembranes of M2 macrophage could facilitate the wound closure in mice. Furthermore, the addition of fibroblast membranes to the macrophage cytomembranes contributed to a better matrix reconstruction, neovascularization and angiogenesis. Next, we used a transforming growth factor-beta (TGF-beta) inhibitor to attenuate cutaneous scar formation. Therefore, our modality could promote skin wound healing and effectively suppress scar formation in the preclinical murine skin wounds. The cytomembrane biologics might provide a biocompatible and versatile tool for wound healing.
资助项目	National Natural Science Foundation of China [11875269]; Natural Science Foundation of Chongqing [cstc2019jcyj-bshX0108]; Postdoctoral Innovation Program of Chongqing, China [CQBX201809]; Special Key Project of Technology Innovation and Application Development of Chongqing, China [cstc2019jscxdxwtBX0032]
出版者	WILEY
出版地	HOBOKEN
ISSN	2380-6761
EISSN	2380-6761
卷号	7 期号:3 页码:e10344
DOI	10.1002/btm2.10344
页数	13
WOS类目	Biotechnology & Applied Microbiology ; Engineering, Biomedical ; Pharmacology & Pharmacy
WOS研究方向	Biotechnology & Applied Microbiology ; Engineering ; Pharmacology & Pharmacy
WOS记录号	WOS:000805364800001
收录类别	SCIE ; EI ; PUBMED ; SCOPUS
EI入藏号	20222312190593
EI主题词	Macrophages
EI分类号	461.1 Biomedical Engineering ; 461.6 Medicine and Pharmacology ; 461.9 Biology ; 461.9.1 Immunology
URL	查看原文
PubMed ID	36176601
SCOPUSEID	2-s2.0-85131160724
通讯作者地址	[Ni, Yilu]The M.O.E. Key Laboratory of Laboratory Medical Diagnostics,The College of Laboratory Medicine,Chongqing Medical University,Yuzhong District,Chongqing,China ; [Hu, Yi]CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,Institute of High Energy Physics and University of Chinese Academy of Sciences (UCAS),Chinese Academy of Sciences (CAS),Beijing,China
Scopus学科分类	Biotechnology;Biomedical Engineering;Pharmaceutical Science
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/148134
专题	检验医学院（生命科学学院、生物学实验教学中心）_模式生物技术与应用重点实验室
通讯作者	Hu, Yi; Ni, Yilu
作者单位	1.The M.O.E. Key Laboratory of Laboratory Medical Diagnostics,The College of Laboratory Medicine,Chongqing Medical University,Yuzhong District,Chongqing,China; 2.CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,Institute of High Energy Physics and University of Chinese Academy of Sciences (UCAS),Chinese Academy of Sciences (CAS),Beijing,China; 3.Zhejiang Provincial Key Laboratory for Technology & Application of Model Organisms,School of Laboratory Medicine and Life Science,Wenzhou Medical University,University Town,Zhejiang,Wenzhou,China
推荐引用方式 GB/T 7714	Wang, Dongqing,Chen, Heying,Lei, Li,et al. Biofabricated macrophage and fibroblast membranes synergistically promote skin wound healing[J]. BIOENGINEERING & TRANSLATIONAL MEDICINE,2022,7(3):e10344.
APA	Wang, Dongqing., Chen, Heying., Lei, Li., Chen, Jun., Gao, Jimin., ... & Ni, Yilu. (2022). Biofabricated macrophage and fibroblast membranes synergistically promote skin wound healing. BIOENGINEERING & TRANSLATIONAL MEDICINE, 7(3), e10344.
MLA	Wang, Dongqing,et al."Biofabricated macrophage and fibroblast membranes synergistically promote skin wound healing".BIOENGINEERING & TRANSLATIONAL MEDICINE 7.3(2022):e10344.