Usefulness of albumin-bilirubin grade for evaluation of long-term prognosis for hepatitis B-related cirrhosis

doi:10.1111/jvh.12638

科研成果详情

题名	Usefulness of albumin-bilirubin grade for evaluation of long-term prognosis for hepatitis B-related cirrhosis
作者	Chen R.-C.1; Cai Y.-J.1; Wu J.-M.2; Wang X.-D.1; Song M.1; Wang Y.-Q.1; Zheng M.-H.1; Chen Y.-P.1; Lin Z.1; Shi K.Q.1
发表日期	2017-03
发表期刊	JOURNAL OF VIRAL HEPATITIS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	albumin-bilirubin cirrhosis decision curves analysis hepatitis B time-dependent receiver operating characteristics
其他关键词	STAGE LIVER-DISEASE ; PLASMA DISAPPEARANCE RATE ; IN-HOSPITAL MORTALITY ; HEPATOCELLULAR-CARCINOMA ; INDOCYANINE GREEN ; MELD SCORE ; CHILD-PUGH ; ALBI GRADE ; MODEL ; TRANSPLANTATION
摘要	Long-term prognosis varies widely among patients with hepatitis B virus (HBV)-related liver cirrhosis. Our study aimed to investigate the applicability of albumin-bilirubin (ALBI), Child-Pugh and model for end-stage liver disease (MELD) scores to the long-term prognosis prediction of HBV-related cirrhosis. Patients diagnosed with HBV-associated cirrhosis from the First Affiliated Hospital of Wenzhou Medical University between January 2010 and December 2015 were enrolled in this study. The patients were followed up every 3months. The prognostic performance of ALBI in long-term outcome prediction for HBV-related cirrhosis was compared with Child-Pugh and MELD scores using time-dependent receiver operating characteristic curve (tdROC) and decision curve analysis. A total of 806 patients were included in our study with 275 (34.1%) deceased during the follow-up. Multivariate Cox regression analysis showed that ALBI grade was an independent predictor associated with mortality. The tdROC analysis showed that ALBI score (0.787, 0.830 and 0.833) was superior to MELD (0.693, P=.003; 0.717, P<.001; 0.744, P<.001) and Child-Pugh score (0.641, P<.001; 0.649, P<.001; 0.657, P<.001) for predicting 1-year, 2-year and 3-year mortality. Additionally, decision curves also got the similar results. In addition, patients with lower ALBI score had a longer life expectancy, even among patients within the same Child-Pugh class. Thus, ALBI score was effective in predicting the long-term prognosis for patients with HBV-related cirrhosis and more accurate than Child-Pugh and MELD scores.
资助项目	Scientific Research Foundation of Wenzhou, Zhejiang Province, China [Y20130073]; Natural Science Foundation of Zhejiang ProvinceNatural Science Foundation of Zhejiang Province [LY16H160047]; National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81201589, 81472651]; Project of New Century 551 Talent Nurturing in Wenzhou; Scientific Research Foundation of Wenzhou, Zhejiang Province, China [Y20130073]; Natural Science Foundation of Zhejiang ProvinceNatural Science Foundation of Zhejiang Province [LY16H160047]; National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81201589, 81472651]; Project of New Century 551 Talent Nurturing in Wenzhou
出版者	WILEY
出版地	HOBOKEN
ISSN	1352-0504
EISSN	1365-2893
卷号	24 期号:3 页码:238-245
DOI	10.1111/jvh.12638
页数	8
WOS类目	Gastroenterology & Hepatology ; Infectious Diseases ; Virology
WOS研究方向	Gastroenterology & Hepatology ; Infectious Diseases ; Virology
WOS记录号	WOS:000393866300007
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	27862671
SCOPUSEID	2-s2.0-85002992025
通讯作者地址	[Lin Z.]Department of Liver Diseases,Liver Research Center,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Hepatology;Infectious Diseases;Virology
引用统计	被引频次：54[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/14709
专题	附属第一医院基因组医学研究院
通讯作者	Lin Z.
作者单位	1.Department of Liver Diseases,Liver Research Center,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.Institute of Genomic Medicine,Wenzhou Medical University,Wenzhou,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Chen R.-C.,Cai Y.-J.,Wu J.-M.,et al. Usefulness of albumin-bilirubin grade for evaluation of long-term prognosis for hepatitis B-related cirrhosis[J]. JOURNAL OF VIRAL HEPATITIS,2017,24(3):238-245.
APA	Chen R.-C.., Cai Y.-J.., Wu J.-M.., Wang X.-D.., Song M.., ... & Shi K.Q.. (2017). Usefulness of albumin-bilirubin grade for evaluation of long-term prognosis for hepatitis B-related cirrhosis. JOURNAL OF VIRAL HEPATITIS, 24(3), 238-245.
MLA	Chen R.-C.,et al."Usefulness of albumin-bilirubin grade for evaluation of long-term prognosis for hepatitis B-related cirrhosis".JOURNAL OF VIRAL HEPATITIS 24.3(2017):238-245.