The effectiveness and safety of Tripterygium wilfordii glycosides combined with disease-modifying anti-rheumatic drugs in the treatment of rheumatoid arthritis: A systematic review and meta-analysis of 40 randomized controlled trials

doi:10.1002/ptr.6996

科研成果详情

题名	The effectiveness and safety of Tripterygium wilfordii glycosides combined with disease-modifying anti-rheumatic drugs in the treatment of rheumatoid arthritis: A systematic review and meta-analysis of 40 randomized controlled trials
作者	Zheng, Wenhao 1; Mei, Yifan2; Chen, Chunhui1; Cai, Leyi1; Chen, Hua1
发表日期	2021-06
发表期刊	PHYTOTHERAPY RESEARCH 影响因子和分区
语种	英语
原始文献类型	Review
关键词	Tripterygium wilfordii glycosides rheumatoid arthritis meta‐ analysis RCT systematic review
其他关键词	HOOK-F ; METHOTREXATE ; GUIDELINES ; ANTICANCER ; EXTRACT ; HERB
摘要	Objective This systematic review and meta-analysis were performed to investigate the efficacy and safety of Tripterygium wilfordii glycosides (TG) for rheumatoid arthritis (RA) from the current literature. Methods An electronic search was conducted in eight databases (PubMed, EMBASE, Web of Science, Cochrane Library, Chinese National Knowledge Infrastructure, Chinese Biomedical Literature Database, Chinese VIP Database, and Wanfang Database) from inception until September 2020. Randomized controlled trials (RCTs) with risk of bias (RoB) score >= 4 according to the Cochrane RoB tool were included for the analyses. The primary outcome measures were duration of morning stiffness (DMS), tender joint count (TJC), swollen joint count (SJC), visual analog score (VAS), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and rheumatoid factor (RF). The secondary outcome measures were the total clinical effective rate and adverse events. All the analyses were used by the random effects models. The meta-analysis was performed using RevMan 5.3 and STATA 14.0. Results A total of 40 RCTs with 3092 patients met our inclusion criteria. This meta-analysis showed that TG plus DMARDs for RA could decrease the DMS (p < .001), TJC (p < .001), SJC (p < .001), VAS (p < .001), serum CRP (p < .001), ESR (p < .001), and RF (p < .001) and improve total effective rate (p < .001). In addition, TG was generally safe and well tolerated in RA patients. Conclusion Despite the limitations, the present evidence supports, at least to an extent, that TG can be recommended for routine use for RA patients. More large multicenter and high-quality RCTs are required for further research.
出版者	WILEY
出版地	HOBOKEN
ISSN	0951-418X
EISSN	1099-1573
卷号	35 期号:6 页码:2902-2924
DOI	10.1002/ptr.6996
页数	23
WOS类目	Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:000601214300001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	33368709
SCOPUSEID	2-s2.0-85099517029
通讯作者地址	[Chen, Hua]Department of Orthopaedic Surgery,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Pharmacology
引用统计	被引频次：8[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/14635
专题	第二临床医学院，附属第二医院、育英儿童医院
通讯作者	Chen, Hua
作者单位	1.Department of Orthopaedic Surgery,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou,China; 2.Department of Emergency,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou,China
第一作者单位	第二临床医学院，附属第二医院、育英儿童医院
通讯作者单位	第二临床医学院，附属第二医院、育英儿童医院
第一作者的第一单位	第二临床医学院，附属第二医院、育英儿童医院
推荐引用方式 GB/T 7714	Zheng, Wenhao,Mei, Yifan,Chen, Chunhui,et al. The effectiveness and safety of Tripterygium wilfordii glycosides combined with disease-modifying anti-rheumatic drugs in the treatment of rheumatoid arthritis: A systematic review and meta-analysis of 40 randomized controlled trials[J]. PHYTOTHERAPY RESEARCH,2021,35(6):2902-2924.
APA	Zheng, Wenhao, Mei, Yifan, Chen, Chunhui, Cai, Leyi, & Chen, Hua. (2021). The effectiveness and safety of Tripterygium wilfordii glycosides combined with disease-modifying anti-rheumatic drugs in the treatment of rheumatoid arthritis: A systematic review and meta-analysis of 40 randomized controlled trials. PHYTOTHERAPY RESEARCH, 35(6), 2902-2924.
MLA	Zheng, Wenhao,et al."The effectiveness and safety of Tripterygium wilfordii glycosides combined with disease-modifying anti-rheumatic drugs in the treatment of rheumatoid arthritis: A systematic review and meta-analysis of 40 randomized controlled trials".PHYTOTHERAPY RESEARCH 35.6(2021):2902-2924.