题名 | Downregulation of carbonic anhydrase IV contributes to promotion of cell proliferation and is associated with poor prognosis in non-small cell lung cancer |
作者 | |
发表日期 | 2017-10 |
发表期刊 | ONCOLOGY LETTERS 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article |
关键词 | non-small cell lung cancer carbonic anhydrase IV proliferation prognosis |
其他关键词 | EXPRESSION ; IX ; STATISTICS ; HYPOXIA |
摘要 | The present study aimed to unveil the biological role of carbonic anhydrase IV (CA IV) and its association with clinical pathological characteristics and prognostic significance in non-small cell lung cancer (NSCLC). The relative expression level of CA IV was measured by reverse transcription-quantitative polymerase chain reaction in 114 resected NSCLC tumors and matched adjacent normal tissues and NSCLC cell lines. Overexpression and cell proliferation were assessed in human NSCLC cell lines transfected with CA IV mRNA by lentivirus-mediated technology. The association of CA IV expression with clinical pathological features and overall survival in 114 cases of NSCLC patients was analyzed. It was demonstrated that CA IV expression was significantly downregulated in NSCLC tumors and six cell lines. Reduced expression of CA IV was significantly correlated with lymph node metastasis. The overall survival of NSCLC patients with low CA IV expression was significantly shorter compared with the high expression group. Overexpression of CA IV suppressed cell proliferation in A549 and NCI-H1299 cells. The results indicate that low expression of CA IV promotes cell proliferation and serves as an indicator for poor prognosis in NSCLC. |
资助项目 | National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [8140736, 81672088]; Zhejiang Provincial Natural Science FoundationNatural Science Foundation of Zhejiang Province [LQ16H160020]; Wenzhou Municipal Science and Technology Bureau, China [Y20150097] |
出版者 | SPANDIDOS PUBL LTD |
出版地 | ATHENS |
ISSN | 1792-1074 |
EISSN | 1792-1082 |
卷号 | 14期号:4页码:5046-5050 |
DOI | 10.3892/ol.2017.6740 |
页数 | 5 |
WOS类目 | Oncology |
WOS研究方向 | Oncology |
WOS记录号 | WOS:000413151300169 |
收录类别 | SCIE ; PUBMED ; SCOPUS |
URL | 查看原文 |
PubMed ID | 29085519 |
PMC记录号 | PMC5649559 |
SCOPUSEID | 2-s2.0-85028941940 |
通讯作者地址 | [Chen, Jie]Department of Intensive Care Unit,The First Affiliated Hospital of Wenzhou Medical University,Fuxue Xian 2,Wenzhou,325000,China |
Scopus学科分类 | Oncology;Cancer Research |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/14529 |
专题 | 附属第一医院 附属第一医院_重症医学科(ICU) |
通讯作者 | Chen, Jie |
作者单位 | 1.Departments of Laboratory Medicine,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 2.Departments of Intensive Care Unit,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 3.Departments of Laboratory Medicine,The First Affiliated Hospital of Wenzhou Medical University,Fuxue Xian 2,Wenzhou,325000,China |
第一作者单位 | 附属第一医院; 第一临床医学院(信息与工程学院)、附属第一医院 |
通讯作者单位 | 附属第一医院; 第一临床医学院(信息与工程学院)、附属第一医院 |
第一作者的第一单位 | 附属第一医院 |
推荐引用方式 GB/T 7714 | Chen, Jian,Hu, Lijuan,Zhang, Fan,et al. Downregulation of carbonic anhydrase IV contributes to promotion of cell proliferation and is associated with poor prognosis in non-small cell lung cancer[J]. ONCOLOGY LETTERS,2017,14(4):5046-5050. |
APA | Chen, Jian, Hu, Lijuan, Zhang, Fan, Wang, Junjun, Chen, Jie, & Wang, Yumin. (2017). Downregulation of carbonic anhydrase IV contributes to promotion of cell proliferation and is associated with poor prognosis in non-small cell lung cancer. ONCOLOGY LETTERS, 14(4), 5046-5050. |
MLA | Chen, Jian,et al."Downregulation of carbonic anhydrase IV contributes to promotion of cell proliferation and is associated with poor prognosis in non-small cell lung cancer".ONCOLOGY LETTERS 14.4(2017):5046-5050. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论