Downregulation of carbonic anhydrase IV contributes to promotion of cell proliferation and is associated with poor prognosis in non-small cell lung cancer

doi:10.3892/ol.2017.6740

科研成果详情

题名	Downregulation of carbonic anhydrase IV contributes to promotion of cell proliferation and is associated with poor prognosis in non-small cell lung cancer
作者	Chen, Jian 1; Hu, Lijuan1; Zhang, Fan 1; Wang, Junjun1; Chen, Jie 2; Wang, Yumin1,3
发表日期	2017-10
发表期刊	ONCOLOGY LETTERS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	non-small cell lung cancer carbonic anhydrase IV proliferation prognosis
其他关键词	EXPRESSION ; IX ; STATISTICS ; HYPOXIA
摘要	The present study aimed to unveil the biological role of carbonic anhydrase IV (CA IV) and its association with clinical pathological characteristics and prognostic significance in non-small cell lung cancer (NSCLC). The relative expression level of CA IV was measured by reverse transcription-quantitative polymerase chain reaction in 114 resected NSCLC tumors and matched adjacent normal tissues and NSCLC cell lines. Overexpression and cell proliferation were assessed in human NSCLC cell lines transfected with CA IV mRNA by lentivirus-mediated technology. The association of CA IV expression with clinical pathological features and overall survival in 114 cases of NSCLC patients was analyzed. It was demonstrated that CA IV expression was significantly downregulated in NSCLC tumors and six cell lines. Reduced expression of CA IV was significantly correlated with lymph node metastasis. The overall survival of NSCLC patients with low CA IV expression was significantly shorter compared with the high expression group. Overexpression of CA IV suppressed cell proliferation in A549 and NCI-H1299 cells. The results indicate that low expression of CA IV promotes cell proliferation and serves as an indicator for poor prognosis in NSCLC.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [8140736, 81672088]; Zhejiang Provincial Natural Science FoundationNatural Science Foundation of Zhejiang Province [LQ16H160020]; Wenzhou Municipal Science and Technology Bureau, China [Y20150097]
出版者	SPANDIDOS PUBL LTD
出版地	ATHENS
ISSN	1792-1074
EISSN	1792-1082
卷号	14 期号:4 页码:5046-5050
DOI	10.3892/ol.2017.6740
页数	5
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000413151300169
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	29085519
PMC记录号	PMC5649559
SCOPUSEID	2-s2.0-85028941940
通讯作者地址	[Chen, Jie]Department of Intensive Care Unit,The First Affiliated Hospital of Wenzhou Medical University,Fuxue Xian 2,Wenzhou,325000,China
Scopus学科分类	Oncology;Cancer Research
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/14529
专题	附属第一医院附属第一医院_重症医学科（ICU）
通讯作者	Chen, Jie
作者单位	1.Departments of Laboratory Medicine,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 2.Departments of Intensive Care Unit,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 3.Departments of Laboratory Medicine,The First Affiliated Hospital of Wenzhou Medical University,Fuxue Xian 2,Wenzhou,325000,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Chen, Jian,Hu, Lijuan,Zhang, Fan,et al. Downregulation of carbonic anhydrase IV contributes to promotion of cell proliferation and is associated with poor prognosis in non-small cell lung cancer[J]. ONCOLOGY LETTERS,2017,14(4):5046-5050.
APA	Chen, Jian, Hu, Lijuan, Zhang, Fan, Wang, Junjun, Chen, Jie, & Wang, Yumin. (2017). Downregulation of carbonic anhydrase IV contributes to promotion of cell proliferation and is associated with poor prognosis in non-small cell lung cancer. ONCOLOGY LETTERS, 14(4), 5046-5050.
MLA	Chen, Jian,et al."Downregulation of carbonic anhydrase IV contributes to promotion of cell proliferation and is associated with poor prognosis in non-small cell lung cancer".ONCOLOGY LETTERS 14.4(2017):5046-5050.