Sesamol Attenuates Neuroinflammation by Regulating the AMPK/SIRT1/NF-kappa B Signaling Pathway after Spinal Cord Injury in Mice

doi:10.1155/2022/8010670

科研成果详情

题名	Sesamol Attenuates Neuroinflammation by Regulating the AMPK/SIRT1/NF-kappa B Signaling Pathway after Spinal Cord Injury in Mice
作者	Feng, Xiaochu; Chen, Xianghang; Zaeem, Muhammad; Zhang, Wanying; Song, Liwan; Chen, Lulu; Mubwandarikwa, Joana; Chen, Xiangxiang; Xiao, Jian; Xie, Ling; Ye, Keyong
发表日期	2022-01-06
发表期刊	OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Cell death Mammals Pathology Anti-inflammation Anti-inflammatory activity Motor function Neuroinflammation Neuronal apoptosis Protein expressions Sesame oil Sesamol Signalling pathways Spinal cord injury
其他关键词	INFLAMMATION ; PROMOTES ; ACTIVATION ; RECOVERY ; POLARIZATION ; DAMAGE
摘要	Inflammation is one of the crucial mechanisms mediating spinal cord injury (SCI) progress. Sesamol, a component of sesame oil, has anti-inflammatory activity, but its mechanism in SCI remains unclear. We investigated if the AMPK/SIRT1/NF-kappa B pathway participated in anti-inflammation of sesamol in SCI. Sesamol could inhibit neuronal apoptosis, reduce neuroinflammation, enhance M2 phenotype microglial polarization, and improved motor function recovery in mice after SCI. Furthermore, sesamol increased SIRT1 protein expression and p-AMPK/AMPK ratio, while it downregulated the p-p65/p65 ratio, indicating that sesamol treatment upregulated the AMPK/SIRT1 pathway and inhibited NF-kappa B activation. However, these effects were blocked by compound C which is a specific AMPK inhibitor. Together, the study suggests that sesamol is a potential drug for antineuroinflammation and improving locomotor functional recovery through regulation of the AMPK/SIRT1/NF-kappa B pathway in SCI.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81972150, 81801233]; Zhejiang Provincial Natural Science FoundationNatural Science Foundation of Zhejiang Province [LR18H150001, LQ18H090008]
出版者	HINDAWI LTD
出版地	LONDON
ISSN	1942-0900
EISSN	1942-0994
卷号	2022 页码:8010670
DOI	10.1155/2022/8010670
页数	51
WOS类目	Cell Biology
WOS研究方向	Cell Biology
WOS记录号	WOS:000748735000005
收录类别	SCIE ; PUBMED ; EI ; SCOPUS
EI入藏号	20220411496560
EI主题词	Patient rehabilitation
EI分类号	461.5 Rehabilitation Engineering and Assistive Technology ; 461.6 Medicine and Pharmacology ; 461.9 Biology
URL	查看原文
PubMed ID	35035666
PMC记录号	PMC8758308
SCOPUSEID	2-s2.0-85123044122
通讯作者地址	[Xiao, Jian]Department of Orthopaedics,Affiliated Pingyang Hospital,School of Pharmaceutical Science,Wenzhou Medical University,Zhejiang,Wenzhou,325000,China ; [Xie, Ling]Department of Orthopaedics,Affiliated Pingyang Hospital,School of Pharmaceutical Science,Wenzhou Medical University,Zhejiang,Wenzhou,325000,China ; [Ye, Keyong]Department of Orthopaedics,Affiliated Pingyang Hospital,School of Pharmaceutical Science,Wenzhou Medical University,Zhejiang,Wenzhou,325000,China
Scopus学科分类	Biochemistry;Aging;Cell Biology
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/14437
专题	药学院（分析测试中心）研究生工作部（研究生院）其他_附属平阳医院（平阳县人民医院）
通讯作者	Xiao, Jian; Xie, Ling; Ye, Keyong
作者单位	Department of Orthopaedics,Affiliated Pingyang Hospital,School of Pharmaceutical Science,Wenzhou Medical University,Wenzhou,325000,China
第一作者单位	附属平阳医院（平阳县人民医院）
通讯作者单位	附属平阳医院（平阳县人民医院）
第一作者的第一单位	附属平阳医院（平阳县人民医院）
推荐引用方式 GB/T 7714	Feng, Xiaochu,Chen, Xianghang,Zaeem, Muhammad,et al. Sesamol Attenuates Neuroinflammation by Regulating the AMPK/SIRT1/NF-kappa B Signaling Pathway after Spinal Cord Injury in Mice[J]. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY,2022,2022:8010670.
APA	Feng, Xiaochu., Chen, Xianghang., Zaeem, Muhammad., Zhang, Wanying., Song, Liwan., ... & Ye, Keyong. (2022). Sesamol Attenuates Neuroinflammation by Regulating the AMPK/SIRT1/NF-kappa B Signaling Pathway after Spinal Cord Injury in Mice. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2022, 8010670.
MLA	Feng, Xiaochu,et al."Sesamol Attenuates Neuroinflammation by Regulating the AMPK/SIRT1/NF-kappa B Signaling Pathway after Spinal Cord Injury in Mice".OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2022(2022):8010670.