Urine Metabolomics in Rats Treated by Alprazolam

科研成果详情

题名	Urine Metabolomics in Rats Treated by Alprazolam
作者	Sun, Fa1; Jiang, Yanyan 2; Yu, Zheng2; Zhang, Zhiguang2; Hu, Lufeng3; Cao, Gaozhong3
发表日期	2018-12-31
发表期刊	LATIN AMERICAN JOURNAL OF PHARMACY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	alprazolam GC-MS metabolomics rats
其他关键词	CHROMATOGRAPHY-MASS SPECTROMETRY ; OF-THE-LITERATURE ; SUPPORT VECTOR MACHINE ; POTENTIAL BIOMARKERS ; TOXICITY ; KETAMINE ; OVERDOSE ; BRAIN ; ABUSE
摘要	Alprazolam indications are mainly used for anxiety, tension, excitement, can be used for hypnotic or anxiety adjuvant drugs, but also as anti-panic drugs, and can alleviate the symptoms of acute alcohol withdrawal. We developed a urine metabolomics to evaluate the effect of alprazolam on rats. The rats were divided into four group, the control group and three dose alprazolam treated group. The alprazolam treated group rats were given 5, 10, 20 mg/kg (Low, Medium, High) of alprazolam by intragastric administration each day for 14 days, the urine samples were colected at the seventh and fourteenth day. Compared to the control group, the level of succinic acid of Low and High group decreased in the fourteen day. Rats exposed to alprazolam, succinic acid decreased, there may be energy metabolism disorders, especially mitochondrial tricarboxylic acid cycle energy generation. Metabolomics could distinguish different alprazolam dose in rats in 14 days, it indicates that metabolomics may be useful to elucidate the effect alprazolam in rats.
资助项目	incubator project of The First Affiliated Hospital of Wenzhou Medical University [FHY2014023, FHY2015030]
出版者	COLEGIO FARMACEUTICOS PROVINCIA DE BUENOS AIRES
出版地	LA PLATA
ISSN	0326-2383
卷号	37 期号:6 页码:1115-1119
页数	5
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:000438254300006
收录类别	SCIE ; SCOPUS
URL	查看原文
Scopus记录号	2-s2.0-85050166788
通讯作者地址	[Hu, Lufeng]Department of Pharmacy,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
scopus学科分类	Pharmaceutical Science;Drug Discovery
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/14347
专题	图书馆（期刊社）_数字图书馆研究与技术中心实验动物中心附属第一医院_药学部药学部
通讯作者	Hu, Lufeng
作者单位	1.Technology Center of Library,Wenzhou Medical University,Wenzhou,325035,China; 2.Laboratory Animal Centre,Wenzhou Medical University,Wenzhou,325035,China; 3.Department of Pharmacy,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
第一作者单位	图书馆（期刊社）
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	图书馆（期刊社）
推荐引用方式 GB/T 7714	Sun, Fa,Jiang, Yanyan,Yu, Zheng,et al. Urine Metabolomics in Rats Treated by Alprazolam[J]. LATIN AMERICAN JOURNAL OF PHARMACY,2018,37(6):1115-1119.
APA	Sun, Fa, Jiang, Yanyan, Yu, Zheng, Zhang, Zhiguang, Hu, Lufeng, & Cao, Gaozhong. (2018). Urine Metabolomics in Rats Treated by Alprazolam. LATIN AMERICAN JOURNAL OF PHARMACY, 37(6), 1115-1119.
MLA	Sun, Fa,et al."Urine Metabolomics in Rats Treated by Alprazolam".LATIN AMERICAN JOURNAL OF PHARMACY 37.6(2018):1115-1119.