题名 | Urine Metabolomics in Rats Treated by Alprazolam |
作者 | |
发表日期 | 2018-12-31 |
发表期刊 | LATIN AMERICAN JOURNAL OF PHARMACY 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article |
关键词 | alprazolam GC-MS metabolomics rats |
其他关键词 | CHROMATOGRAPHY-MASS SPECTROMETRY ; OF-THE-LITERATURE ; SUPPORT VECTOR MACHINE ; POTENTIAL BIOMARKERS ; TOXICITY ; KETAMINE ; OVERDOSE ; BRAIN ; ABUSE |
摘要 | Alprazolam indications are mainly used for anxiety, tension, excitement, can be used for hypnotic or anxiety adjuvant drugs, but also as anti-panic drugs, and can alleviate the symptoms of acute alcohol withdrawal. We developed a urine metabolomics to evaluate the effect of alprazolam on rats. The rats were divided into four group, the control group and three dose alprazolam treated group. The alprazolam treated group rats were given 5, 10, 20 mg/kg (Low, Medium, High) of alprazolam by intragastric administration each day for 14 days, the urine samples were colected at the seventh and fourteenth day. Compared to the control group, the level of succinic acid of Low and High group decreased in the fourteen day. Rats exposed to alprazolam, succinic acid decreased, there may be energy metabolism disorders, especially mitochondrial tricarboxylic acid cycle energy generation. Metabolomics could distinguish different alprazolam dose in rats in 14 days, it indicates that metabolomics may be useful to elucidate the effect alprazolam in rats. |
资助项目 | incubator project of The First Affiliated Hospital of Wenzhou Medical University [FHY2014023, FHY2015030] |
出版者 | COLEGIO FARMACEUTICOS PROVINCIA DE BUENOS AIRES |
出版地 | LA PLATA |
ISSN | 0326-2383 |
卷号 | 37期号:6页码:1115-1119 |
页数 | 5 |
WOS类目 | Pharmacology & Pharmacy |
WOS研究方向 | Pharmacology & Pharmacy |
WOS记录号 | WOS:000438254300006 |
收录类别 | SCIE ; SCOPUS |
URL | 查看原文 |
Scopus记录号 | 2-s2.0-85050166788 |
通讯作者地址 | [Hu, Lufeng]Department of Pharmacy,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China |
scopus学科分类 | Pharmaceutical Science;Drug Discovery |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/14347 |
专题 | 图书馆(期刊社)_数字图书馆研究与技术中心 实验动物中心 附属第一医院_药学部药学部 |
通讯作者 | Hu, Lufeng |
作者单位 | 1.Technology Center of Library,Wenzhou Medical University,Wenzhou,325035,China; 2.Laboratory Animal Centre,Wenzhou Medical University,Wenzhou,325035,China; 3.Department of Pharmacy,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China |
第一作者单位 | 图书馆(期刊社) |
通讯作者单位 | 附属第一医院; 第一临床医学院(信息与工程学院)、附属第一医院 |
第一作者的第一单位 | 图书馆(期刊社) |
推荐引用方式 GB/T 7714 | Sun, Fa,Jiang, Yanyan,Yu, Zheng,et al. Urine Metabolomics in Rats Treated by Alprazolam[J]. LATIN AMERICAN JOURNAL OF PHARMACY,2018,37(6):1115-1119. |
APA | Sun, Fa, Jiang, Yanyan, Yu, Zheng, Zhang, Zhiguang, Hu, Lufeng, & Cao, Gaozhong. (2018). Urine Metabolomics in Rats Treated by Alprazolam. LATIN AMERICAN JOURNAL OF PHARMACY, 37(6), 1115-1119. |
MLA | Sun, Fa,et al."Urine Metabolomics in Rats Treated by Alprazolam".LATIN AMERICAN JOURNAL OF PHARMACY 37.6(2018):1115-1119. |
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