题名 | Serum levels of 14-3-3 eta are associated with increased disease risk, activity and duration of rheumatoid arthritis in Chinese patients |
作者 | |
发表日期 | 2020-08 |
发表期刊 | EXPERIMENTAL AND THERAPEUTIC MEDICINE 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article |
关键词 | rheumatoid arthritis 14-3-3 eta disease risk disease activity disease duration Chinese |
其他关键词 | C-REACTIVE PROTEIN ; JOINT DAMAGE ; INFLAMMATION ; PROGRESSION ; ALPHA |
摘要 | The aim of the present study was to determine the association between serum 14-3-3 eta expression levels and disease risk, inflammation level and disease duration in Chinese patients with rheumatoid arthritis (RA). A total of 45 Chinese patients with RA, 45 patients with osteoarthritis (OA) and 44 age- and sex-matched (with the RA group) healthy control (HC) subjects were consecutively recruited for the present case-controlled study. In addition, the demographic and clinicopathological characteristics of the patients with RA were collected. Serum samples were obtained from patients with RA, patients with OA and the HCs, and the serum levels of 14-3-3 eta were determined by ELISA. Compared with that in the OA patients (P=0.006) and HCs (P<0.001), 14-3-3 eta expression was significantly increased in RA patients, and receiver operating characteristics (ROC) analysis indicated that it served as a potential predictive marker for the risk of RA. In patients with RA, serum levels of 14-3-3 eta were positively correlated with disease duration (P=0.003), erythrocyte sedimentation rate (P=0.006) and disease activity score in 28 joints (P=0.025). The proportion of rheumatoid factor (RF)-positive patients (P=0.023) and anti-citrullinated protein antibody (ACPA)-positive patients (P=0.002) with RA was increased (when 14-3-3 eta expression was increased) compared with RF-negative patients or ACPA-negative patients, respectively. Of note, 14-3-3 eta serum levels were able to distinguish patients with established RA (disease duration, >2 years) from patients with early RA (disease duration, <= 2 years) with an AUC of 0.759 (95% CI, 0.612-0.905), and the sensitivity and the specificity at the best cut-off point (14-3-3 eta=0.613 ng/ml) were 79.3 and 75.0%, respectively. Furthermore, 14-3-3 eta was able to differentiate between RF-positive RA patients and RF-negative patients or HCs. In conclusion, circulating 14-3-3 eta expression may serve as a novel biomarker for disease risk and activity of RA in Chinese patients. |
资助项目 | Science and Technology Project of Wenzhou [Y20170060, Y20170056]; Science and Technology Action Plan for Major Disease Control-Trauma Repair Special Project, National Health and Family Planning Commission Medical Science and Technology Development Research Center [ZX-01-C2016029] |
出版者 | SPANDIDOS PUBL LTD |
出版地 | ATHENS |
ISSN | 1792-0981 |
EISSN | 1792-1015 |
卷号 | 20期号:2页码:754-761 |
DOI | 10.3892/etm.2020.8761 |
页数 | 8 |
WOS类目 | Medicine, Research & Experimental |
WOS研究方向 | Research & Experimental Medicine |
WOS记录号 | WOS:000562806200008 |
收录类别 | SCIE ; PUBMED |
URL | 查看原文 |
PubMed ID | 32742321 |
PMC记录号 | PMC7388387 |
通讯作者地址 | [Xia, Xiaoru;Sun, Li]Wenzhou Med Univ, Dept Rheumatol & Immunol, Affiliated Hosp 1, 2 Fuxue Lane, Wenzhou 325000, Zhejiang, Peoples R China. |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/14301 |
专题 | 附属第一医院_风湿免疫科 检验医学院(生命科学学院、生物学实验教学中心) |
通讯作者 | Xia, Xiaoru; Sun, Li |
作者单位 | 1.Wenzhou Med Univ, Dept Rheumatol & Immunol, Affiliated Hosp 1, 2 Fuxue Lane, Wenzhou 325000, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Dept Lab Med, Affiliated Hosp 1, Wenzhou 325000, Zhejiang, Peoples R China; 3.Wenzhou Med Univ, Dept Orthopaed Sports Med, Affiliated Hosp 1, Wenzhou 325000, Zhejiang, Peoples R China |
第一作者单位 | 附属第一医院; 风湿免疫科 |
通讯作者单位 | 附属第一医院; 风湿免疫科 |
第一作者的第一单位 | 附属第一医院 |
推荐引用方式 GB/T 7714 | Tu, Jianxin,Chen, Xiaowei,Dai, Meijie,et al. Serum levels of 14-3-3 eta are associated with increased disease risk, activity and duration of rheumatoid arthritis in Chinese patients[J]. EXPERIMENTAL AND THERAPEUTIC MEDICINE,2020,20(2):754-761. |
APA | Tu, Jianxin., Chen, Xiaowei., Dai, Meijie., Pan, Axiao., Liu, Cailong., ... & Sun, Li. (2020). Serum levels of 14-3-3 eta are associated with increased disease risk, activity and duration of rheumatoid arthritis in Chinese patients. EXPERIMENTAL AND THERAPEUTIC MEDICINE, 20(2), 754-761. |
MLA | Tu, Jianxin,et al."Serum levels of 14-3-3 eta are associated with increased disease risk, activity and duration of rheumatoid arthritis in Chinese patients".EXPERIMENTAL AND THERAPEUTIC MEDICINE 20.2(2020):754-761. |
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