科研成果详情

题名Lentivirus-mediated overexpression of miR-124 suppresses growth and invasion by targeting JAG1 and EZH2 in gastric cancer
作者
发表日期2018-05
发表期刊ONCOLOGY LETTERS   影响因子和分区
语种英语
原始文献类型Article
关键词microRNA-124 lentivirus Jagged1 enhancer of zeste homolog 2 gastric cancer
其他关键词INHIBITS CELL-PROLIFERATION ; BREAST-CANCER ; HEPATOCELLULAR-CARCINOMA ; DOWN-REGULATION ; PROTEOMIC ANALYSIS ; LUNG-CANCER ; METASTASIS ; PROGRESSION ; MICRORNA-124 ; APOPTOSIS
摘要MicroRNA-124 (miR-124) expression is downregulated and has a tumor suppressor role in various types of cancer. The present study revealed that genes encoding miR-124 were frequently methylated and the expression of miR-124 was downregulated in gastric cancer tissues. Stable expression of miR-124 using a lentiviral vector inhibited gastric cancer cell growth, migration and invasion in vitro. In addition, overexpression of miR-124 suppressed gastric cancer cell xenograft growth in nude mice. The expression of the Notch ligand Jagged1 (JAG1) and enhancer of zeste homolog 2 (EZH2) was downregulated upon miR-124 overexpression, and silencing of JAG1 or EZH2 by RNA interference also suppressed gastric cancer cell growth, migration and invasion. Furthermore, expression of fibronectin and vimentin, not able elements of the epithelial-mesenchymal transition, were suppressed by overexpression of miR-124 or inhibition of JAG1 or EZH2 expressions in GC. Together, these results indicated that miR-124 suppressed gastric cancer progression, partly through inhibiting JAG1 and EZH2. Thus, lentivirus-mediated overexpression of miR-124 may be a potential therapeutic strategy against gastric cancer.
资助项目National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81672385]; Science Research Foundation of National Health and Family Planning commission of China [WKJ-ZJ-1416]; Zhejiang Provincial Natural Science Foundation of ChinaNatural Science Foundation of Zhejiang Province [LY14H16004]
出版者SPANDIDOS PUBL LTD
出版地ATHENS
ISSN1792-1074
EISSN1792-1082
卷号15期号:5页码:7450-7458
DOI10.3892/ol.2018.8194
页数9
WOS类目Oncology
WOS研究方向Oncology
WOS记录号WOS:000431825900181
收录类别SCIE ; PUBMED ; SCOPUS
URL查看原文
PubMed ID29731896
PMC记录号PMC5921033
SCOPUSEID2-s2.0-85044648881
通讯作者地址[Jin, Rong]Department of Epidemiology,The First Affiliated Hospital of Wenzhou Medical University,1 South Baixiang Street,Wenzhou,325000,China
Scopus学科分类Oncology;Cancer Research
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/1416
专题附属第一医院
第一临床医学院(信息与工程学院)、附属第一医院_中心实验室
通讯作者Jin, Rong
作者单位
1.Department of Gastroenterology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China;
2.Central Laboratory,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China;
3.Department of Epidemiology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
第一作者单位附属第一医院;  第一临床医学院(信息与工程学院)、附属第一医院
通讯作者单位附属第一医院;  第一临床医学院(信息与工程学院)、附属第一医院
第一作者的第一单位附属第一医院
推荐引用方式
GB/T 7714
Pan, Yangyang,Wu, Aihua,Xu, Fanfan,et al. Lentivirus-mediated overexpression of miR-124 suppresses growth and invasion by targeting JAG1 and EZH2 in gastric cancer[J]. ONCOLOGY LETTERS,2018,15(5):7450-7458.
APA Pan, Yangyang, Wu, Aihua, Xu, Fanfan, Chen, Chao, Jiang, Lei, & Jin, Rong. (2018). Lentivirus-mediated overexpression of miR-124 suppresses growth and invasion by targeting JAG1 and EZH2 in gastric cancer. ONCOLOGY LETTERS, 15(5), 7450-7458.
MLA Pan, Yangyang,et al."Lentivirus-mediated overexpression of miR-124 suppresses growth and invasion by targeting JAG1 and EZH2 in gastric cancer".ONCOLOGY LETTERS 15.5(2018):7450-7458.

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