Curcumol may alleviate psoriasis-like inflammation by inhibiting kerarinocyte proliferation and inflammatory gene expression via JAK1/STAT3 signaling

科研成果详情

题名	Curcumol may alleviate psoriasis-like inflammation by inhibiting kerarinocyte proliferation and inflammatory gene expression via JAK1/STAT3 signaling
作者	Lv, Mingfen; Shao, Junyi; Jiang, Fan; Liu, Jingjing
发表日期	2021-07-28
发表期刊	AGING-US 影响因子和分区
语种	英语
原始文献类型	Article
关键词	psoriasis curcumol proliferation inflammation differentiation
其他关键词	SKIN INFLAMMATION ; STAT3 ; CELLS ; PATHOGENESIS ; PATHWAYS ; IL-22 ; MICE
摘要	Psoriasis is a chronic inflammatory skin disease characterized by abnormal proliferation and differentiation of keratinocytes. Since curcumol exhibits anti-inflammatory properties in various diseases, we investigated its anti-inflammatory potential in stimulated human keratinocytes. Our data show that curcumol significantly inhibits proliferation and induces cell cycle arrest in NHEK cells stimulated with proinflammatory cytokines (IL-la, IL-17A, IL-22, oncostatin M, and TNF-a; mix M5). In addition, curcumol markedly ameliorates inflammatory response and promotes differentiation of MS-stimulated NHEK cells. Curcumol inhibits activity of JAK1, resulting in the inhibition of STAT3, downregulation of cyclin D2, and cell cycle arrest in stimulated NHEK cells. Together, our data show that curcumol reduces proliferation and inflammatory gene expression in stimulated keratinocytes by inhibiting the JAK1/STAT3 signaling, suggesting that it might serve as a potential therapeutic option for the treatment of psoriasis.
出版者	IMPACT JOURNALS LLC
出版地	ORCHARD PARK
ISSN	1945-4589
卷号	13 期号:14 页码:18392-18403
WOS类目	Cell Biology ; Geriatrics & Gerontology
WOS研究方向	Cell Biology ; Geriatrics & Gerontology
WOS记录号	WOS:000683030900006
收录类别	SCIE
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/13595
专题	附属第一医院_皮肤科
通讯作者	Liu, Jingjing
作者单位	Wenzhou Med Univ, Dept Dermatol, Affiliated Hosp 1, Wenzhou 325000, Zhejiang, Peoples R China
第一作者单位	皮肤科
第一作者的第一单位	皮肤科; 皮肤科
推荐引用方式 GB/T 7714	Lv, Mingfen,Shao, Junyi,Jiang, Fan,et al. Curcumol may alleviate psoriasis-like inflammation by inhibiting kerarinocyte proliferation and inflammatory gene expression via JAK1/STAT3 signaling[J]. AGING-US,2021,13(14):18392-18403.
APA	Lv, Mingfen, Shao, Junyi, Jiang, Fan, & Liu, Jingjing. (2021). Curcumol may alleviate psoriasis-like inflammation by inhibiting kerarinocyte proliferation and inflammatory gene expression via JAK1/STAT3 signaling. AGING-US, 13(14), 18392-18403.
MLA	Lv, Mingfen,et al."Curcumol may alleviate psoriasis-like inflammation by inhibiting kerarinocyte proliferation and inflammatory gene expression via JAK1/STAT3 signaling".AGING-US 13.14(2021):18392-18403.