题名 | MYC promotes the development of papillary thyroid carcinoma by inhibiting the expression of lncRNA PAX8-AS1:28 |
作者 | |
发表日期 | 2019-04 |
发表期刊 | ONCOLOGY REPORTS 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article |
关键词 | papillary thyroid carcinoma lncRNA PAX8-AS1:28 siRNA expression inhibition |
其他关键词 | LONG NONCODING RNA ; PATHOGENESIS ; CANCER |
摘要 | As a common malignancy of the endocrine system, papillary thyroid carcinoma (PTC) seriously affects the quality of life of patients. lncRNA PAX8-AS1:28, or lnc-PSD4-1:14 has been reported to be abnormally expressed in PTC. However, the function of PAX8-AS1:28 in PTC is still unknown. Therefore, the present study aimed to investigate the functions of PAX8-AS1:28 in PTC, and to explore the possible mechanisms of action. A total of 38 patients with PTC were included and the normal thyroid follicular epithelial cell line Nthy-ori 3-1 and PTC cell line IHH-4 were also used. MYC and PAX8-AS1:28 overexpression and siRNA silencing in the cell lines were carried out. Expression of PAX8-AS1:28, PAX8 and MYC in tumor tissue, adjacent healthy tissue and different cell lines were detected by qRT-PCR and western blot analysis. Cell proliferation was measured by CCK-8 assay. Expression levels of PAX8-AS1:28 and PAX8 were lower in PTC tumor tissue and PTC cells than those in healthy tissue and normal cells. In contrast, the expression level of MYC was higher in PTC cells than that in normal cells. PAX8-AS1:28 silencing reduced the expression level of PAX8 and promoted tumor cell growth, while PAX8-AS1:28 overexpression increased the expression level of PAX8 and inhibited tumor cell growth. MYC silencing increased expression levels of PAX8-AS1:28 and PAX8 and inhibited tumor cell growth, while MYC overexpression decreased expression levels of PAX8-AS1:28 and PAX8 and promoted tumor cell growth. MYC can promote PTC by inhibiting the expression of lncRNA PAX8-AS1:28. |
资助项目 | Natural Science Foundation of Zhejiang ProvinceNatural Science Foundation of Zhejiang Province [LY14H190003] |
出版者 | SPANDIDOS PUBL LTD |
出版地 | ATHENS |
ISSN | 1021-335X |
EISSN | 1791-2431 |
卷号 | 41期号:4页码:2511-2517 |
DOI | 10.3892/or.2019.6996 |
页数 | 7 |
WOS类目 | Oncology |
WOS研究方向 | Oncology |
WOS记录号 | WOS:000461025800041 |
收录类别 | SCIE ; PUBMED ; SCOPUS |
URL | 查看原文 |
Pubmed记录号 | 30720110 |
Scopus记录号 | 2-s2.0-85062240712 |
通讯作者地址 | [Chen, Jun]Department of Immunology,Wenzhou Medical University,Chashan Higher Education Park,Ouhai, Wenzhou, Zhejiang,325000,China |
scopus学科分类 | Oncology;Cancer Research |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/13485 |
专题 | 第二临床医学院、附属第二医院、育英儿童医院 附属第二医院 基础医学院(机能实验教学中心)_病原生物学与免疫学系_医学免疫学 |
通讯作者 | Chen, Jun |
作者单位 | 1.Department of Neck Surgery,Wenzhou Medical University,Wenzhou, Zhejiang,325000,China; 2.Department of Immunology,Wenzhou Medical University,Chashan Higher Education Park,Ouhai, Wenzhou, Zhejiang,325000,China |
第一作者单位 | 温州医科大学 |
通讯作者单位 | 温州医科大学 |
第一作者的第一单位 | 温州医科大学 |
推荐引用方式 GB/T 7714 | Zhang, Yi,Li, Feilei,Chen, Jun. MYC promotes the development of papillary thyroid carcinoma by inhibiting the expression of lncRNA PAX8-AS1:28[J]. ONCOLOGY REPORTS,2019,41(4):2511-2517. |
APA | Zhang, Yi, Li, Feilei, & Chen, Jun. (2019). MYC promotes the development of papillary thyroid carcinoma by inhibiting the expression of lncRNA PAX8-AS1:28. ONCOLOGY REPORTS, 41(4), 2511-2517. |
MLA | Zhang, Yi,et al."MYC promotes the development of papillary thyroid carcinoma by inhibiting the expression of lncRNA PAX8-AS1:28".ONCOLOGY REPORTS 41.4(2019):2511-2517. |
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