miR-4698-Trim59 axis plays a suppressive role in hepatocellular carcinoma

doi:10.2741/4849

科研成果详情

题名	miR-4698-Trim59 axis plays a suppressive role in hepatocellular carcinoma
作者	Yu, Dandan1; Zhu, Liqing1; Tu, Hongxiang1; Wu, Lingjian2; Yang, Huimin3; Xu, Chunquan1
发表日期	2020-03-01
发表期刊	FRONTIERS IN BIOSCIENCE-LANDMARK 影响因子和分区
语种	英语
原始文献类型	Article
关键词	miR-4698 HCC Trim59 Cell growth Motility
其他关键词	COLORECTAL-CANCER ; MICRORNAS ; TRIM59 ; BIOGENESIS ; MIRNAS ; GENE
摘要	microRNAs (miRNAs) are important in tumor suppression and oncogenesis. In this study, we aimed to explore the role of miR-4698 with its potential target, Tripartite motif-containing 59 (Trim59), a protein with oncogenic function, in hepatocellular carcinoma (HCC). The expression of miR-4698 was significantly lower in HCC tissues and HCC cell lines as compared to the levels expressed in normal tissues adjacent to tumors and in normal hepatic cell line. Overexpression of miR-4698 in HCC cells by transfection of its mimic significantly inhibited cell growth, migration, invasion and epithelial-mesenchymal transition (EMT), whereas, its antisense oligonucleotides (ASOs) exerted an opposite effect. Trim59 was identified as a target of miR-4698 in miRDB and consistent with this, the expression of Trim59 was inversely correlated with miR-4698 in HCC, and miR-4698 overexpression led to a significant decrease in luciferase activity of pRL-Trim59-3'UTR, but not mutant pRL-Trim59-3'-UTR. Moreover, miR-4698 mimic inhibited the expression of Trim59. Overexpression of Trim59 abrogated the inhibitory effects of miR-4698. In conclusion, these data show that miR-4698-Trim59 axis plays a tumor suppressive role in HCC.
出版者	FRONTIERS IN BIOSCIENCE INC
出版地	IRVINE
ISSN	1093-9946
EISSN	1093-4715
卷号	25 期号:6 页码:1120-1131
DOI	10.2741/4849
页数	12
WOS类目	Biochemistry & Molecular Biology ; Cell Biology
WOS研究方向	Biochemistry & Molecular Biology ; Cell Biology
WOS记录号	WOS:000563769600005
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	32114426
SCOPUSEID	2-s2.0-85080840842
通讯作者地址	[Xu, Chunquan]Department of Clinical Laboratory,First Affiliated Hospital of Wenzhou Medical University,2 Fuxue Lane,Wenzhou, Zhejiang,325000,China
Scopus学科分类	Biochemistry, Genetics and Molecular Biology (all);Immunology and Microbiology (all)
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/13467
专题	第一临床医学院（信息与工程学院）、附属第一医院_临床检验诊断学附属第一医院_皮肤科附属第一医院_输血科
通讯作者	Xu, Chunquan
作者单位	1.Department of Clinical Laboratory,First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang,China; 2.Department of Dermatology,First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang,China; 3.Department of Blood Bank,First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang,China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Yu, Dandan,Zhu, Liqing,Tu, Hongxiang,et al. miR-4698-Trim59 axis plays a suppressive role in hepatocellular carcinoma[J]. FRONTIERS IN BIOSCIENCE-LANDMARK,2020,25(6):1120-1131.
APA	Yu, Dandan, Zhu, Liqing, Tu, Hongxiang, Wu, Lingjian, Yang, Huimin, & Xu, Chunquan. (2020). miR-4698-Trim59 axis plays a suppressive role in hepatocellular carcinoma. FRONTIERS IN BIOSCIENCE-LANDMARK, 25(6), 1120-1131.
MLA	Yu, Dandan,et al."miR-4698-Trim59 axis plays a suppressive role in hepatocellular carcinoma".FRONTIERS IN BIOSCIENCE-LANDMARK 25.6(2020):1120-1131.