Development of a model based on biochemical, real-time tissue elastography and ultrasound data for the staging of liver fibrosis and cirrhosis in patients with chronic hepatitis B

doi:10.3892/mmr.2016.5682

科研成果详情

题名	Development of a model based on biochemical, real-time tissue elastography and ultrasound data for the staging of liver fibrosis and cirrhosis in patients with chronic hepatitis B
作者	Xu, Shi-Hao; Li, Qiao; Hu, Yuan-Ping; Ying, Li
发表日期	2016-10
发表期刊	MOLECULAR MEDICINE REPORTS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	real-time tissue elastography liver fibrosis index chronic hepatitis B liver fibrosis cirrhosis
其他关键词	CHRONIC VIRAL-HEPATITIS ; C VIRUS-INFECTION ; NONINVASIVE EVALUATION ; DIAGNOSTIC-ACCURACY ; EFSUMB GUIDELINES ; CLINICAL-USE ; DISEASE ; MANAGEMENT ; SYSTEM ; RECOMMENDATIONS
摘要	The liver fibrosis index (LFI), based on real-time tissue elastography (RTE), is a method currently used to assess liver fibrosis. However, this method may not consistently distinguish between the different stages of fibrosis, which limits its accuracy. The aim of the present study was to develop novel models based on biochemical, RTE and ultrasound data for predicting significant liver fibrosis and cirrhosis. A total of 85 consecutive patients with chronic hepatitis B (CHB) were prospectively enrolled and underwent a liver biopsy and RTE. The parameters for predicting significant fibrosis and cirrhosis were determined by conducting multivariate analyses. The splenoportal index (SPI; P=0.002) and LFI (P=0.023) were confirmed as independent predictors of significant fibrosis. Using multivariate analyses for identifying parameters that predict cirrhosis, significant differences in -glutamyl transferase (GGT; P=0.049), SPI (P=0.002) and LFI (P=0.001) were observed. Based on these observations, the novel model LFI-SPI score (LSPS) was developed to predict the occurrence of significant liver fibrosis, with an area under receiver operating characteristic curves (AUROC) of 0.87. The diagnostic accuracy of the LSPS model was superior to that of the LFI (AUROC=0.76; P=0.0109), aspartate aminotransferase-to-platelet ratio index (APRI; AUROC=0.64; P=0.0031), fibrosis-4 index (FIB-4; AUROC= 0.67; P= 0.0044) and FibroScan (AUROC=0.68; P=0.0021) models. In addition, the LFI-SPI-GGT score (LSPGS) was developed for the purposes of predicting liver cirrhosis, demonstrating an AUROC value of 0.93. The accuracy of LSPGS was similar to that of FibroScan (AUROC=0.85; P=0.134), but was superior to LFI (AUROC= 0.81; P= 0.0113), APRI (AUROC= 0.67; P<0.0001) and FIB-4 (AUROC=0.719; P=0.0005). In conclusion, the results of the present study suggest that the use of LSPS and LSPGS may complement current methods of diagnosing significant liver fibrosis and cirrhosis in patients with CHB.
资助项目	Scientific Research Foundation of Wenzhou [Y20100042]
出版者	SPANDIDOS PUBL LTD
出版地	ATHENS
ISSN	1791-2997
EISSN	1791-3004
卷号	14 期号:4 页码:3609-3619
DOI	10.3892/mmr.2016.5682
页数	11
WOS类目	Oncology ; Medicine, Research & Experimental
WOS研究方向	Oncology ; Research & Experimental Medicine
WOS记录号	WOS:000385580800095
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	27573619
PMC记录号	PMC5042746
SCOPUSEID	2-s2.0-84988473754
通讯作者地址	[Ying, Li]Department of Ultrasonography,First Affiliated Hospital of Wenzhou Medical University,2 Fuxue Lane,Wenzhou, Zhejiang,325000,China
Scopus学科分类	Biochemistry;Molecular Medicine;Molecular Biology;Genetics;Oncology;Cancer Research
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/13354
专题	附属第一医院
通讯作者	Ying, Li
作者单位	Department of Ultrasonography,First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang,325000,China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Xu, Shi-Hao,Li, Qiao,Hu, Yuan-Ping,et al. Development of a model based on biochemical, real-time tissue elastography and ultrasound data for the staging of liver fibrosis and cirrhosis in patients with chronic hepatitis B[J]. MOLECULAR MEDICINE REPORTS,2016,14(4):3609-3619.
APA	Xu, Shi-Hao, Li, Qiao, Hu, Yuan-Ping, & Ying, Li. (2016). Development of a model based on biochemical, real-time tissue elastography and ultrasound data for the staging of liver fibrosis and cirrhosis in patients with chronic hepatitis B. MOLECULAR MEDICINE REPORTS, 14(4), 3609-3619.
MLA	Xu, Shi-Hao,et al."Development of a model based on biochemical, real-time tissue elastography and ultrasound data for the staging of liver fibrosis and cirrhosis in patients with chronic hepatitis B".MOLECULAR MEDICINE REPORTS 14.4(2016):3609-3619.