Effects of curcumin on TTX-R sodium currents of dorsal root ganglion neurons in type 2 diabetic rats with diabetic neuropathic pain

doi:10.1016/j.neulet.2015.08.011

科研成果详情

题名	Effects of curcumin on TTX-R sodium currents of dorsal root ganglion neurons in type 2 diabetic rats with diabetic neuropathic pain
作者	Meng, Bo 1; Shen, Lu-lu 1; Shi, Xiao-ting 1; Gong, Yong-sheng2; Fan, Xiao-fang2; Li, Jun1; Cao, Hong1
发表日期	2015-09-25
发表期刊	NEUROSCIENCE LETTERS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Curcumin Type 2 diabetic mellitus Diabetic neuropathic pain Dorsal root ganglion TTX-R sodium currents
其他关键词	SENSORY NEURONS ; CHANNELS ; EXPRESSION ; COMBINATION ; MECHANISMS ; THRESHOLD ; INSULIN ; INJURY ; ALPHA ; MODEL
摘要	Type 2 diabetic mellitus (T2DM) has reached pandemic status and shows no signs of abatement. Diabetic neuropathic pain (DNP) is generally considered to be one of the most common complications of T2DM, which is also recognized as one of the most difficult types of pain to treat. As one kind of peripheral neuropathic pain, DNP manifests typical chronic neuralgia symptoms, including hyperalgesia, allodynia, autotomy, and so on. The injured dorsal root ganglion (DRG) is considered as the first stage of the sensory pathway impairment, whose neurons display increased frequency of action potential generation and increased spontaneous activities. These are mainly due to the changed properties of voltage-gated sodium channels (VGSCs) and the increased sodium currents, especially TTX-R sodium currents. Curcumin, one of the most important phytochemicals from turmeric, has been demonstrated to effectively prevent and/or ameliorate diabetic mellitus and its complications including DNP. The present study demonstrates that the TTX-R sodium currents of small-sized DRG neurons isolated from DNP rats are significantly increased. Such abnormality can be efficaciously ameliorated by curcumin. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81073125]; Natural Science Foundation of Zhejiang ProvinceNatural Science Foundation of Zhejiang Province [Y2090252]
出版者	ELSEVIER IRELAND LTD
出版地	CLARE
ISSN	0304-3940
EISSN	1872-7972
卷号	605 页码:59-64
DOI	10.1016/j.neulet.2015.08.011
页数	6
WOS类目	Neurosciences
WOS研究方向	Neurosciences & Neurology
WOS记录号	WOS:000362918200012
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	26282904
SCOPUSEID	2-s2.0-84940030489
通讯作者地址	[Cao, Hong]Department of Anesthesiology, The 2nd Affiliated Hospital of Wenzhou Medical University,No. 109, Xuyuanxi Road,Wenzhou,325027,China
Scopus学科分类	Neuroscience (all)
引用统计	被引频次：14[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/13214
专题	第二临床医学院，附属第二医院、育英儿童医院附属第二医院基础医学院（机能实验教学中心）_基础医学实验教学中心_机能实验教学中心（挂靠、校级）
通讯作者	Cao, Hong
作者单位	1.Department of Anesthesiology, The 2nd Affiliated Hospital of Wenzhou Medical University,No. 109, Xuyuanxi Road,Wenzhou,325027,China; 2.Teaching Center of Medical Functional Experiment, Wenzhou Medical University,Wenzhou,China
第一作者单位	第二临床医学院，附属第二医院、育英儿童医院; 附属第二医院
通讯作者单位	第二临床医学院，附属第二医院、育英儿童医院; 附属第二医院
第一作者的第一单位	第二临床医学院，附属第二医院、育英儿童医院; 附属第二医院
推荐引用方式 GB/T 7714	Meng, Bo,Shen, Lu-lu,Shi, Xiao-ting,et al. Effects of curcumin on TTX-R sodium currents of dorsal root ganglion neurons in type 2 diabetic rats with diabetic neuropathic pain[J]. NEUROSCIENCE LETTERS,2015,605:59-64.
APA	Meng, Bo., Shen, Lu-lu., Shi, Xiao-ting., Gong, Yong-sheng., Fan, Xiao-fang., ... & Cao, Hong. (2015). Effects of curcumin on TTX-R sodium currents of dorsal root ganglion neurons in type 2 diabetic rats with diabetic neuropathic pain. NEUROSCIENCE LETTERS, 605, 59-64.
MLA	Meng, Bo,et al."Effects of curcumin on TTX-R sodium currents of dorsal root ganglion neurons in type 2 diabetic rats with diabetic neuropathic pain".NEUROSCIENCE LETTERS 605(2015):59-64.