TLR2 regulates angiotensin II-induced vascular remodeling and EndMT through NF-kappa B signaling

科研成果详情

题名	TLR2 regulates angiotensin II-induced vascular remodeling and EndMT through NF-kappa B signaling
作者	Lin, Ke 1,2; Luo, Wu1; Yan, Jueqian 1; Shen, Siyuan1,2; Shen, Qirui 1; Wang, Jun 3,4; Guan, Xinfu 5; Wu, Gaojun2; Huang, Weijian2; Liang, Guang1,2,5
发表日期	2021-01-31
发表期刊	AGING-US 影响因子和分区
语种	英语
原始文献类型	Article
关键词	endothelial to mesenchymal transition TLR2 angiotensin II vascular remodeling NF-kappa B
其他关键词	AORTIC-ANEURYSM FORMATION ; MESENCHYMAL TRANSITION ; CARDIAC FIBROSIS ; INFLAMMATION ; ATHEROSCLEROSIS ; SUPPRESSION ; INHIBITION ; MECHANISMS ; DELETION ; DISEASE
摘要	Excessive vascular remodeling has been shown in hypertensive patients. In experimental models of hypertensive vascular injury, such as angiotensin II (Ang II) challenged mice, toll like receptor 2 (TLR2) initiates inflammatory responses. More recently, studies have reported atypical endothelial to mesenchymal transition (EndMT) in vascular injuries and inflammatory conditions. Here, we aimed to investigate whether TLR2 mediates Ang II-induced vascular inflammation and initiates EndMT. In a mouse model of angiotensin II induced hypertension, we show that aortas exhibit increased medial thickening, fibrosis, and features of EndMT. These alterations were not observed in TLR2 knockout mice in response to Ang II. TLR2 silencing in cultured endothelial cells confirmed the essential role of TLR2 in Ang II-induced inflammatory factor induction, and EndMT-associated phenotypic change. Mechanistically, we found Ang II activates nuclear factor-KB signaling, inducing pro-inflammatory cytokine production, and mediates EndMT in both cultured endothelial cells and in mice. These studies illustrate a novel role of TLR2 in regulating Ang II-induced deleterious vascular remodeling through the induction of EndMT. The studies also suggest that TLR2 may be targeted to alleviate hypertension-associated vascular injury.
资助项目	National Key Research Project [2017YFA0506000]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81770799, 21961142009]; Natural Science Foundation of Zhejiang ProvinceNatural Science Foundation of Zhejiang Province [LY18H020013, LY19H020004]; Zhejiang Provincial Key Scientific Project [2018C03068]; Wenzhou Science and Technology Key Project [2018ZY009]
出版者	IMPACT JOURNALS LLC
出版地	ORCHARD PARK
ISSN	1945-4589
卷号	13 期号:2 页码:2553-2574
页数	22
WOS类目	Cell Biology ; Geriatrics & Gerontology
WOS研究方向	Cell Biology ; Geriatrics & Gerontology
WOS记录号	WOS:000614651300007
收录类别	SCIE
通讯作者地址	[Liang, Guang]Wenzhou Med Univ, Chem Biol Res Ctr, Sch Pharmaceut Sci, Wenzhou 325035, Zhejiang, Peoples R China. ; [Huang, Weijian;Liang, Guang]Wenzhou Med Univ, Dept Cardiol, Affiliated Hosp 1, Wenzhou 325035, Zhejiang, Peoples R China. ; [Liang, Guang]Wenzhou Med Univ, Affiliated Cangnan Hosp, Cangnan 325800, Zhejiang, Peoples R China.
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/12946
专题	药学院（分析测试中心）_生物有机与药物化学研究中心附属第一医院其他_附属苍南医院（苍南县人民医院）其他_定理临床学院（温州市中心医院）
通讯作者	Huang, Weijian; Liang, Guang
作者单位	1.Wenzhou Med Univ, Chem Biol Res Ctr, Sch Pharmaceut Sci, Wenzhou 325035, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Dept Cardiol, Affiliated Hosp 1, Wenzhou 325035, Zhejiang, Peoples R China; 3.Wenzhou Med Univ, Wenzhou Cent Hosp, Dept Cardiol, Wenzhou 325035, Zhejiang, Peoples R China; 4.Wenzhou Med Univ, Affiliated Dingli Clin Inst, Wenzhou 325035, Zhejiang, Peoples R China; 5.Wenzhou Med Univ, Affiliated Cangnan Hosp, Cangnan 325800, Zhejiang, Peoples R China
第一作者单位	药学院（分析测试中心）_生物有机与药物化学研究中心; 附属第一医院
通讯作者单位	药学院（分析测试中心）_生物有机与药物化学研究中心; 附属第一医院; 其他_附属苍南医院（苍南县人民医院）
第一作者的第一单位	药学院（分析测试中心）_生物有机与药物化学研究中心
推荐引用方式 GB/T 7714	Lin, Ke,Luo, Wu,Yan, Jueqian,et al. TLR2 regulates angiotensin II-induced vascular remodeling and EndMT through NF-kappa B signaling[J]. AGING-US,2021,13(2):2553-2574.
APA	Lin, Ke., Luo, Wu., Yan, Jueqian., Shen, Siyuan., Shen, Qirui., ... & Liang, Guang. (2021). TLR2 regulates angiotensin II-induced vascular remodeling and EndMT through NF-kappa B signaling. AGING-US, 13(2), 2553-2574.
MLA	Lin, Ke,et al."TLR2 regulates angiotensin II-induced vascular remodeling and EndMT through NF-kappa B signaling".AGING-US 13.2(2021):2553-2574.