科研成果详情

题名Inverse Relationship Between Serum Bilirubin Levels and Diabetic Foot in Chinese Patients with Type 2 Diabetes Mellitus
作者
发表日期2017-12-14
发表期刊MEDICAL SCIENCE MONITOR   影响因子和分区
语种英语
原始文献类型Article
关键词Amputation Bilirubin Diabetes Mellitus Diabetic Foot Diabetic Neuropathies Peripheral Arterial Disease
其他关键词PERIPHERAL ARTERIAL-DISEASE ; IWGDF GUIDANCE DOCUMENTS ; FOLLOW-UP ; MANAGEMENT ; PROGRESSION ; ASSOCIATION ; PREVENTION ; NEUROPATHY ; AMPUTATION ; ULCERS
摘要Background: Several studies demonstrated that bilirubin, a potent endogenous antioxidant, is a strong protective factor for many diabetic complications such as nephropathy, retinopathy, neuropathy, and vasculopathy. The purpose of this study was to assess the association between serum bilirubin levels and diabetic foot (DF) in Chinese patients with type 2 diabetes mellitus (T2DM). Material/Methods: The present cross-sectional study of bilirubin levels in relation to DF was conducted in 1,269 T2DM patients with (n=578) and without (n=691) DF. Blood test results were obtained on hospital admission, including total bilirubin (T-BIL), direct bilirubin (D-BIL), and indirect bilirubin (I-BIL). Data on Wagner classification and amputation procedure in patients with DF were collected by reviewing electronic medical records. Univariate or multivariate analysis were performed to explore the association between bilirubin and DF. Results: Serum I-BIL levels were shown to play a protective role regarding the presence and severity of DF (OR=0.75, p=0.029 and OR=0.90, p=0.021, respectively). In addition, in a comparison of the lowest and highest tertiles of serum bilirubin concentration, the highest tertile of serum T-BIL (OR=0.51, p=0.011) and I-BIL (OR=0.28, p<0.001) was significantly related with a lower Wagner grade of DF. Patients with DF in the highest tertiles of T-BIL carried a significantly lower risk of amputation events than those in the lowest tertiles (OR=0.47, p=0.025). Conclusions: The present study provided evidence that decreased serum bilirubin levels were independently associated with the presence and severity of DF and amputation events in patients with DF.
资助项目Natural Science Foundation of Zhejiang provinceNatural Science Foundation of Zhejiang Province [LY17H070005]
出版者INT SCIENTIFIC LITERATURE, INC
出版地SMITHTOWN
ISSN1643-3750
EISSN1643-3750
卷号23页码:5916-5923
DOI10.12659/MSM.907248
页数8
WOS类目Medicine, Research & Experimental
WOS研究方向Research & Experimental Medicine
WOS记录号WOS:000417956700001
收录类别SCIE ; SCOPUS ; PUBMED
URL查看原文
PubMed ID29238034
PMC记录号PMC5739530
SCOPUSEID2-s2.0-85039705174
通讯作者地址[Zhu, Hong]Department of Endocrinology and Metabolism,The First Affiliated Hospital,Wenzhou Medical University,Wenzhou,China
Scopus学科分类Medicine (all)
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/1259
专题第一临床医学院(信息与工程学院)、附属第一医院
附属第一医院_内分泌科
通讯作者Zhu, Hong
作者单位
1.School of the First Clinical Medical Sciences,Wenzhou Medical University,Wenzhou,China;
2.Department of Endocrinology and Metabolism,The First Affiliated Hospital,Wenzhou Medical University,Wenzhou,China
第一作者单位温州医科大学
通讯作者单位附属第一医院
第一作者的第一单位温州医科大学
推荐引用方式
GB/T 7714
Chen, Jifan,Wang, Jian,Zhang, Xingxing,et al. Inverse Relationship Between Serum Bilirubin Levels and Diabetic Foot in Chinese Patients with Type 2 Diabetes Mellitus[J]. MEDICAL SCIENCE MONITOR,2017,23:5916-5923.
APA Chen, Jifan, Wang, Jian, Zhang, Xingxing, & Zhu, Hong. (2017). Inverse Relationship Between Serum Bilirubin Levels and Diabetic Foot in Chinese Patients with Type 2 Diabetes Mellitus. MEDICAL SCIENCE MONITOR, 23, 5916-5923.
MLA Chen, Jifan,et al."Inverse Relationship Between Serum Bilirubin Levels and Diabetic Foot in Chinese Patients with Type 2 Diabetes Mellitus".MEDICAL SCIENCE MONITOR 23(2017):5916-5923.

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