Inverse Relationship Between Serum Bilirubin Levels and Diabetic Foot in Chinese Patients with Type 2 Diabetes Mellitus

doi:10.12659/MSM.907248

科研成果详情

题名	Inverse Relationship Between Serum Bilirubin Levels and Diabetic Foot in Chinese Patients with Type 2 Diabetes Mellitus
作者	Chen, Jifan 1; Wang, Jian 1; Zhang, Xingxing 2; Zhu, Hong2
发表日期	2017-12-14
发表期刊	MEDICAL SCIENCE MONITOR 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Amputation Bilirubin Diabetes Mellitus Diabetic Foot Diabetic Neuropathies Peripheral Arterial Disease
其他关键词	PERIPHERAL ARTERIAL-DISEASE ; IWGDF GUIDANCE DOCUMENTS ; FOLLOW-UP ; MANAGEMENT ; PROGRESSION ; ASSOCIATION ; PREVENTION ; NEUROPATHY ; AMPUTATION ; ULCERS
摘要	Background: Several studies demonstrated that bilirubin, a potent endogenous antioxidant, is a strong protective factor for many diabetic complications such as nephropathy, retinopathy, neuropathy, and vasculopathy. The purpose of this study was to assess the association between serum bilirubin levels and diabetic foot (DF) in Chinese patients with type 2 diabetes mellitus (T2DM). Material/Methods: The present cross-sectional study of bilirubin levels in relation to DF was conducted in 1,269 T2DM patients with (n=578) and without (n=691) DF. Blood test results were obtained on hospital admission, including total bilirubin (T-BIL), direct bilirubin (D-BIL), and indirect bilirubin (I-BIL). Data on Wagner classification and amputation procedure in patients with DF were collected by reviewing electronic medical records. Univariate or multivariate analysis were performed to explore the association between bilirubin and DF. Results: Serum I-BIL levels were shown to play a protective role regarding the presence and severity of DF (OR=0.75, p=0.029 and OR=0.90, p=0.021, respectively). In addition, in a comparison of the lowest and highest tertiles of serum bilirubin concentration, the highest tertile of serum T-BIL (OR=0.51, p=0.011) and I-BIL (OR=0.28, p<0.001) was significantly related with a lower Wagner grade of DF. Patients with DF in the highest tertiles of T-BIL carried a significantly lower risk of amputation events than those in the lowest tertiles (OR=0.47, p=0.025). Conclusions: The present study provided evidence that decreased serum bilirubin levels were independently associated with the presence and severity of DF and amputation events in patients with DF.
资助项目	Natural Science Foundation of Zhejiang provinceNatural Science Foundation of Zhejiang Province [LY17H070005]
出版者	INT SCIENTIFIC LITERATURE, INC
出版地	SMITHTOWN
ISSN	1643-3750
EISSN	1643-3750
卷号	23 页码:5916-5923
DOI	10.12659/MSM.907248
页数	8
WOS类目	Medicine, Research & Experimental
WOS研究方向	Research & Experimental Medicine
WOS记录号	WOS:000417956700001
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	29238034
PMC记录号	PMC5739530
SCOPUSEID	2-s2.0-85039705174
通讯作者地址	[Zhu, Hong]Department of Endocrinology and Metabolism,The First Affiliated Hospital,Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Medicine (all)
引用统计	被引频次：15[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/1259
专题	第一临床医学院（信息与工程学院）、附属第一医院附属第一医院_内分泌科
通讯作者	Zhu, Hong
作者单位	1.School of the First Clinical Medical Sciences,Wenzhou Medical University,Wenzhou,China; 2.Department of Endocrinology and Metabolism,The First Affiliated Hospital,Wenzhou Medical University,Wenzhou,China
第一作者单位	温州医科大学
通讯作者单位	附属第一医院
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Chen, Jifan,Wang, Jian,Zhang, Xingxing,et al. Inverse Relationship Between Serum Bilirubin Levels and Diabetic Foot in Chinese Patients with Type 2 Diabetes Mellitus[J]. MEDICAL SCIENCE MONITOR,2017,23:5916-5923.
APA	Chen, Jifan, Wang, Jian, Zhang, Xingxing, & Zhu, Hong. (2017). Inverse Relationship Between Serum Bilirubin Levels and Diabetic Foot in Chinese Patients with Type 2 Diabetes Mellitus. MEDICAL SCIENCE MONITOR, 23, 5916-5923.
MLA	Chen, Jifan,et al."Inverse Relationship Between Serum Bilirubin Levels and Diabetic Foot in Chinese Patients with Type 2 Diabetes Mellitus".MEDICAL SCIENCE MONITOR 23(2017):5916-5923.