Dynamic changes of platelets before and after surgery predict the prognosis of patients with operable non-small cell lung cancer

doi:10.7150/jca.65129

科研成果详情

题名	Dynamic changes of platelets before and after surgery predict the prognosis of patients with operable non-small cell lung cancer
作者	Yang, Wei1,2; Yao, Yating 3; Chen, Yingying 4; Jin, Fangsi3; Zheng, Tingting3; Ai, Xinyi 3; Zhang, Ting3; Ding, Chunming1,2; Jiang, Minghua3
发表日期	2022
发表期刊	JOURNAL OF CANCER 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Non-small cell lung cancer (NSCLC) postoperative platelet preoperative platelet ratio (PPR) prognosis time-dependent ROC
其他关键词	THROMBOCYTOSIS ; PODOPLANIN ; COUNTS
摘要	Purpose: To determine the prognostic significance of postoperative platelet/preoperative platelet ratio (PPR) in patients with operable non-small cell lung cancer (NSCLC), and assess its prognostic benefit compared to models relying solely preoperative platelet counts (PLT). Materials and Methods: A retrospective analysis of 403 patients who underwent radical resection of NSCLC in our institution from 2013 to 2018 was conducted to assess the prognostic significance of PLT and PPR. Progression-free survival (PFS) and overall survival (OS) were performed by the Kaplan-Meier method. Single-factor and multi-factor COX regression models were used to determine factors that affect long-term outcomes. Time-dependent ROC was used to evaluate the value of PPR in predicting the prognosis. Results: A significant association between high PLT and PPR and poor long-term patient survival outcomes was observed. The median PFS and OS of NSCLC patients with high PLT were 25 months and 29 months, which was significantly shorter than that of patients with low PLT (30 months and 33 months) (both P = 0.002). In addition, the median PFS and OS of NSCLC patients with high PPR were 18 months and 26.5 months, which was significantly shorter than that of patients with low PPR (33 months and 35 months) (both P<0.001). Univariate and Multivariate analysis using Cox regression model showed that PLT and PPR were independent factors affecting PFS and OS. Time-dependent ROC showed that the predictive capability of PLT and PPR preserved well when they were compared over time following surgery. The AUCs of PLT and PPR to predict 1-year PFS and OS, 3-year PFS and OS, 5-year PFS and OS stabilized between 0.528-0.607. PPR showed significantly higher accuracy than PLT in the prediction of 1-year and 3-year PFS and OS. Conclusions: Elevated PPR is significantly related to the adverse outcomes of patients with NSCLC. PPR can stably predict the long-term prognosis of patients, and can be used as a reliable indicator for evaluating the prognosis of patients with operable NSCLC.
资助项目	Natural Science Foundation of Zhejiang ProvinceNatural Science Foundation of Zhejiang Province [LY20H200002]; Zhejiang Xinmiao Talents Program [2019R413067]
出版者	IVYSPRING INT PUBL
出版地	LAKE HAVEN
ISSN	1837-9664
卷号	13 期号:3 页码:823-830
DOI	10.7150/jca.65129
页数	8
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000747119400001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	35154451
PMC记录号	PMC8824881
SCOPUSEID	2-s2.0-85123281469
通讯作者地址	[Ding, Chunming]School of Laboratory Medicine and Life Science,Wenzhou Medical University,Zhejiang,Wenzhou,325035,China ; [Jiang, Minghua]Department of Laboratory Medicine,The Second Affiliated Hospital,Yuying Children's Hospital,Wenzhou Medical University,Zhejiang,Wenzhou,China
Scopus学科分类	Oncology
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/12377
专题	检验医学院（生命科学学院、生物学实验教学中心）温州医科大学附属第二医院
通讯作者	Ding, Chunming; Jiang, Minghua
作者单位	1.School of Laboratory Medicine and Life Science,Wenzhou Medical University,Zhejiang,Wenzhou,325035,China; 2.Key Laboratory of Laboratory Medicine,Ministry of Education,Wenzhou Medical University,Zhejiang,Wenzhou,325035,China; 3.Department of Laboratory Medicine,The Second Affiliated Hospital,Yuying Children's Hospital,Wenzhou Medical University,Zhejiang,Wenzhou,China; 4.Otolaryngology department,The Second Affiliated Hospital,Yuying Children's Hospital,Wenzhou Medical University,Zhejiang,Wenzhou,China
第一作者单位	检验医学院（生命科学学院、生物学实验教学中心）; 温州医科大学
通讯作者单位	检验医学院（生命科学学院、生物学实验教学中心）; 附属第二医院
第一作者的第一单位	检验医学院（生命科学学院、生物学实验教学中心）
推荐引用方式 GB/T 7714	Yang, Wei,Yao, Yating,Chen, Yingying,et al. Dynamic changes of platelets before and after surgery predict the prognosis of patients with operable non-small cell lung cancer[J]. JOURNAL OF CANCER,2022,13(3):823-830.
APA	Yang, Wei., Yao, Yating., Chen, Yingying., Jin, Fangsi., Zheng, Tingting., ... & Jiang, Minghua. (2022). Dynamic changes of platelets before and after surgery predict the prognosis of patients with operable non-small cell lung cancer. JOURNAL OF CANCER, 13(3), 823-830.
MLA	Yang, Wei,et al."Dynamic changes of platelets before and after surgery predict the prognosis of patients with operable non-small cell lung cancer".JOURNAL OF CANCER 13.3(2022):823-830.