题名 | Study on Association of Pentraxin 3 and Diabetic Nephropathy in a Rat Model |
作者 | |
发表日期 | 2018-12-31 |
发表期刊 | JOURNAL OF DIABETES RESEARCH 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article |
其他关键词 | PANCREATIC-ISLET TRANSPLANTATION ; KIDNEY CAPSULE ; PTX3 ; INJURY ; CELLS |
摘要 | Diabetic nephropathy (DN) is a serious microvascular complication of diabetes. Compared with other therapies for diabetic patients, islet transplantation can effectively prevent and reverse diabetes-induced microvascular disease, such as diabetic retinopathy and nephropathy. PTX3 is the only long pentraxin that can be detected in renal tissue. In this study, we investigated the expression of PTX3 when early DN was reversed after islet transplantation. Methods. Diabetes was induced in rats by injecting streptozotocin (STZ). Twelve weeks later, the diabetic rats were divided into 2 groups: the islet transplantation group (IT) and the diabetic nephropathy group (DN). Renal injury, renal function, and the expression of PTX3 in the plasma and the kidneys were assessed with urinalysis, immunohistochemical staining, and Western blot, respectively. Results. The expression of PTX3 in the kidney was significantly decreased in the DN group but increased in the IT group because of the reversal of DN. Conclusions. Our data showed that the level of PTX3 in renal tissue is closely related to renal injury in DN. This may be used to quantify the extent of renal injury in DN, provide a potential early indicator of renal tubular injury in early DN patients, and assess DN clinical progression. |
资助项目 | National Health and Family Planning Commission of Zhejiang Province [2013ZDA014]; National Natural Science of ChinaNational Natural Science Foundation of China (NSFC) [81572087]; Natural Science Foundation of Zhejiang ProvinceNatural Science Foundation of Zhejiang Province [LY17H070005, LY2H05004, LY16H030013]; Wenzhou Municipal Science and Bureau [Y20140672, Y20150062] |
出版者 | HINDAWI LTD |
出版地 | LONDON |
ISSN | 2314-6745 |
EISSN | 2314-6753 |
卷号 | 2018页码:8968573 |
DOI | 10.1155/2018/8968573 |
页数 | 10 |
WOS类目 | Endocrinology & Metabolism ; Medicine, Research & Experimental |
WOS研究方向 | Endocrinology & Metabolism ; Research & Experimental Medicine |
WOS记录号 | WOS:000428377400001 |
收录类别 | SCIE ; PUBMED ; SCOPUS |
URL | 查看原文 |
PubMed ID | 29725602 |
PMC记录号 | PMC5872604 |
SCOPUSEID | 2-s2.0-85054400475 |
通讯作者地址 | [Zhu, Hong]Department of Endocrinology,First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang,325000,China |
Scopus学科分类 | Endocrinology, Diabetes and Metabolism;Endocrinology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/12289 |
专题 | 第一临床医学院(信息与工程学院)、附属第一医院 附属第一医院_内分泌科 |
通讯作者 | Zhu, Hong |
作者单位 | 1.Department of Surgery,First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang,325000,China; 2.Zhejiang Provincial Top Key Discipline in Surgery,Wenzhou Key Laboratory of Surgery,Department of Surgery,First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang,325000,China; 3.Department of Endocrinology,First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang,325000,China |
第一作者单位 | 附属第一医院 |
通讯作者单位 | 附属第一医院 |
第一作者的第一单位 | 附属第一医院 |
推荐引用方式 GB/T 7714 | Chen, Xuehai,Luo, Jiao,Wu, Minmin,et al. Study on Association of Pentraxin 3 and Diabetic Nephropathy in a Rat Model[J]. JOURNAL OF DIABETES RESEARCH,2018,2018:8968573. |
APA | Chen, Xuehai., Luo, Jiao., Wu, Minmin., Pan, Zhuo., Xie, Yue., ... & Zhu, Hong. (2018). Study on Association of Pentraxin 3 and Diabetic Nephropathy in a Rat Model. JOURNAL OF DIABETES RESEARCH, 2018, 8968573. |
MLA | Chen, Xuehai,et al."Study on Association of Pentraxin 3 and Diabetic Nephropathy in a Rat Model".JOURNAL OF DIABETES RESEARCH 2018(2018):8968573. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论