Study on Association of Pentraxin 3 and Diabetic Nephropathy in a Rat Model

doi:10.1155/2018/8968573

科研成果详情

题名	Study on Association of Pentraxin 3 and Diabetic Nephropathy in a Rat Model
作者	Chen, Xuehai1; Luo, Jiao 1; Wu, Minmin1; Pan, Zhuo 1; Xie, Yue 1; Wang, Hongwei 1; Chen, Bicheng1,2; Zhu, Hong3
发表日期	2018-12-31
发表期刊	JOURNAL OF DIABETES RESEARCH 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	PANCREATIC-ISLET TRANSPLANTATION ; KIDNEY CAPSULE ; PTX3 ; INJURY ; CELLS
摘要	Diabetic nephropathy (DN) is a serious microvascular complication of diabetes. Compared with other therapies for diabetic patients, islet transplantation can effectively prevent and reverse diabetes-induced microvascular disease, such as diabetic retinopathy and nephropathy. PTX3 is the only long pentraxin that can be detected in renal tissue. In this study, we investigated the expression of PTX3 when early DN was reversed after islet transplantation. Methods. Diabetes was induced in rats by injecting streptozotocin (STZ). Twelve weeks later, the diabetic rats were divided into 2 groups: the islet transplantation group (IT) and the diabetic nephropathy group (DN). Renal injury, renal function, and the expression of PTX3 in the plasma and the kidneys were assessed with urinalysis, immunohistochemical staining, and Western blot, respectively. Results. The expression of PTX3 in the kidney was significantly decreased in the DN group but increased in the IT group because of the reversal of DN. Conclusions. Our data showed that the level of PTX3 in renal tissue is closely related to renal injury in DN. This may be used to quantify the extent of renal injury in DN, provide a potential early indicator of renal tubular injury in early DN patients, and assess DN clinical progression.
资助项目	National Health and Family Planning Commission of Zhejiang Province [2013ZDA014]; National Natural Science of ChinaNational Natural Science Foundation of China (NSFC) [81572087]; Natural Science Foundation of Zhejiang ProvinceNatural Science Foundation of Zhejiang Province [LY17H070005, LY2H05004, LY16H030013]; Wenzhou Municipal Science and Bureau [Y20140672, Y20150062]
出版者	HINDAWI LTD
出版地	LONDON
ISSN	2314-6745
EISSN	2314-6753
卷号	2018 页码:8968573
DOI	10.1155/2018/8968573
页数	10
WOS类目	Endocrinology & Metabolism ; Medicine, Research & Experimental
WOS研究方向	Endocrinology & Metabolism ; Research & Experimental Medicine
WOS记录号	WOS:000428377400001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	29725602
PMC记录号	PMC5872604
SCOPUSEID	2-s2.0-85054400475
通讯作者地址	[Zhu, Hong]Department of Endocrinology,First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang,325000,China
Scopus学科分类	Endocrinology, Diabetes and Metabolism;Endocrinology
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/12289
专题	第一临床医学院（信息与工程学院）、附属第一医院附属第一医院_内分泌科
通讯作者	Zhu, Hong
作者单位	1.Department of Surgery,First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang,325000,China; 2.Zhejiang Provincial Top Key Discipline in Surgery,Wenzhou Key Laboratory of Surgery,Department of Surgery,First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang,325000,China; 3.Department of Endocrinology,First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang,325000,China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Chen, Xuehai,Luo, Jiao,Wu, Minmin,et al. Study on Association of Pentraxin 3 and Diabetic Nephropathy in a Rat Model[J]. JOURNAL OF DIABETES RESEARCH,2018,2018:8968573.
APA	Chen, Xuehai., Luo, Jiao., Wu, Minmin., Pan, Zhuo., Xie, Yue., ... & Zhu, Hong. (2018). Study on Association of Pentraxin 3 and Diabetic Nephropathy in a Rat Model. JOURNAL OF DIABETES RESEARCH, 2018, 8968573.
MLA	Chen, Xuehai,et al."Study on Association of Pentraxin 3 and Diabetic Nephropathy in a Rat Model".JOURNAL OF DIABETES RESEARCH 2018(2018):8968573.