Thyroid hormone levels as a predictor marker predict the prognosis of patients with sepsis

doi:10.1016/j.ajem.2021.02.014

科研成果详情

题名	Thyroid hormone levels as a predictor marker predict the prognosis of patients with sepsis
作者	Wang, Yiping1; Sun, Fangyuan 2; Hong, Guangliang1; Lu, Zhongqiu1
发表日期	2021-07
发表期刊	AMERICAN JOURNAL OF EMERGENCY MEDICINE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Sepsis Outcomes Thyroid hormone T-4 Thyroxin fT(4),free thyroxin MIMIC-III
摘要	Background: Sepsis is a systemic inflammatory response syndrome with high mortality. There is an upward trend in sepsis prevalence and mortality worldwide. Early and accurate prediction of outcome in sepsis is important. There remains a great need to improve a reliable prognostic model for sepsis patients with widely available variables. The aim of this study was to explore the correlation between serum thyroid hormone levels and prognosis in sepsis patients. Methods: Septic patients were identified from the Medical Information Mart for Intensive Care (MIMIC)-III database. Factors that were found to contribute to the outcome in the uni-variate analysis at P value <0.1 were included in the multivariate. Multivariate analysis was performed by binary logistic regression analysis, which allows adjust for confounding factors. We combined an assessment of thyroid hormone and some variables together, which improve the accurate prediction of outcome. The accuracy of the test was assessed measuring the area under the ROC curve (AUROC). Results: A total of 929 eligible septic patients were included in the data analysis. Seventy hundred and three patients had a good functional outcome, whereas 226 patients had a bad functional outcome. Thyroxin (T-4) level was significantly decreased in patients with an unfavorable functional outcome as compared to patients with a favorable functional outcome (P < 0.01). Binary logistic regression analyses revealed that lower thyroxin concentrations on admission were associated with a risk for poor outcomes (OR 0.556, 95% CI 0.41-0.75: P < 0.01). In addition, in ROC curve analysis, the combined model AUROC was 0.82 for ICU survival, which was significantly higher than the AUROCs of original fT(4) (0.65 and 0.65), T-4 (0.71 and 0.71) and SAPSII (0.70 and 0.72) (all P < 0.05). Conclusions: Low serum thyroxin levels can be a predictive marker of short-term outcome after sepsis. A combined model (fT(4), T-4 and SAPSII score) can add significant additional predictive information to the clinical score of the SAPSII. (C) 2021 The Authors. Published by Elsevier Inc.
资助项目	Research Incubation Project of the First Affiliated Hospital of Wenzhou Medical University
出版者	W B SAUNDERS CO-ELSEVIER INC
出版地	PHILADELPHIA
ISSN	0735-6757
EISSN	1532-8171
卷号	45 页码:42-47
DOI	10.1016/j.ajem.2021.02.014
页数	6
WOS类目	Emergency Medicine
WOS研究方向	Emergency Medicine
WOS记录号	WOS:000729665500008
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	33652253
SCOPUSEID	2-s2.0-85101644046
通讯作者地址	[Lu, Zhongqiu]Department of Emergency,the First Affiliated Hospital of WenZhou Medical University,Wenzhou,325000,China
Scopus学科分类	Emergency Medicine
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/12207
专题	附属第一医院_急诊科第一临床医学院（信息与工程学院）、附属第一医院_计算机与信息管理系
通讯作者	Lu, Zhongqiu
作者单位	1.Department of Emergency,the First Affiliated Hospital of WenZhou Medical University,Wenzhou,325000,China; 2.Department of Computer Technology and Information Management,the First Affiliated Hospital of WenZhou Medical University,Wenzhou,325000,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Wang, Yiping,Sun, Fangyuan,Hong, Guangliang,et al. Thyroid hormone levels as a predictor marker predict the prognosis of patients with sepsis[J]. AMERICAN JOURNAL OF EMERGENCY MEDICINE,2021,45:42-47.
APA	Wang, Yiping, Sun, Fangyuan, Hong, Guangliang, & Lu, Zhongqiu. (2021). Thyroid hormone levels as a predictor marker predict the prognosis of patients with sepsis. AMERICAN JOURNAL OF EMERGENCY MEDICINE, 45, 42-47.
MLA	Wang, Yiping,et al."Thyroid hormone levels as a predictor marker predict the prognosis of patients with sepsis".AMERICAN JOURNAL OF EMERGENCY MEDICINE 45(2021):42-47.