Intra-articular drug delivery systems for osteoarthritis therapy: shifting from sustained release to enhancing penetration into cartilage

doi:10.1080/10717544.2022.2048130

科研成果详情

题名	Intra-articular drug delivery systems for osteoarthritis therapy: shifting from sustained release to enhancing penetration into cartilage
作者	Huang, Huirong 1; Lou, Zijian 1,2; Zheng, Shimin 1; Wu, Jianing 1; Yao, Qing3; Chen, Ruijie1; Kou, Longfa1; Chen, Daosen2
发表期刊	DRUG DELIVERY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Drug delivery system osteoarthritis sustained-release permeability intra-articular
其他关键词	MESENCHYMAL STEM-CELLS ; HYALURONIC-ACID ; ARTICULAR-CARTILAGE ; KNEE OSTEOARTHRITIS ; IN-VIVO ; CHONDROGENIC DIFFERENTIATION ; PLGA MICROSPHERES ; PROTEIN CORONA ; NANOPARTICLES ; RETENTION
摘要	Osteoarthritis (OA) is a progressive chronic inflammation that leads to cartilage degeneration. OA Patients are commonly given pharmacological treatment, but the available treatments are not sufficiently effective. The development of sustained-release drug delivery systems (DDSs) for OA may be an attractive strategy to prevent rapid drug clearance and improve the half-life of a drug at the joint cavity. Such delivery systems will improve the therapeutic effects of anti-inflammatory effects in the joint cavity. Whereas, for disease-modifying OA drugs (DMOADs) which target chondrocytes or act on mesenchymal stem cells (MSCs), the cartilage-permeable DDSs are required to maximize their efficacy. This review provides an overview of joint structure in healthy and pathological conditions, introduces the advances of the sustained-release DDSs and the permeable DDSs, and discusses the rational design of the permeable DDSs for OA treatment. We hope that the ideas generated in this review will promote the development of effective OA drugs in the future.
资助项目	Zhejiang Medical and Health Science and Technology Program [2021KY795]; Wenzhou Municipal Science and Technology Bureau [ZY2019007]; National College Students Innovation and Enterpreneurship Training Program [202110343039]
出版者	TAYLOR & FRANCIS LTD
出版地	ABINGDON
ISSN	1071-7544
EISSN	1521-0464
卷号	29 期号:1 页码:767-791
DOI	10.1080/10717544.2022.2048130
页数	25
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:000766367900001
收录类别	SCIE ; PUBMED ; SCOPUS
发表日期	2022-12-31
URL	查看原文
Pubmed记录号	35261301
PMC记录号	PMC8920370
Scopus记录号	2-s2.0-85126078681
ESI高被引论文	2023-03 ; 2023-05 ; 2023-07 ; 2023-09 ; 2023-11 ; 2024-01 ; 2024-03 ; 2024-05
引用统计	被引频次：8[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/12186
专题	第二临床医学院、附属第二医院、育英儿童医院药学院（分析测试中心）
通讯作者	Kou, Longfa; Chen, Daosen
作者单位	1.Wenzhou Med Univ, Dept Pharm, Wenzhou Municipal Key Lab Pediat Pharm, Affiliated Hosp & Yuying Childrens Hosp 2, 109 Xueyuan West Rd, Wenzhou 325027, Peoples R China; 2.Wenzhou Med Univ, Dept Orthoped, Affiliated Hosp & Yuying Childrens Hosp 2, 109 Xueyuan West Rd, Wenzhou 325027, Peoples R China; 3.Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou, Peoples R China
第一作者单位	第二临床医学院，附属第二医院、育英儿童医院
通讯作者单位	第二临床医学院，附属第二医院、育英儿童医院
第一作者的第一单位	第二临床医学院，附属第二医院、育英儿童医院
推荐引用方式 GB/T 7714	Huang, Huirong,Lou, Zijian,Zheng, Shimin,et al. Intra-articular drug delivery systems for osteoarthritis therapy: shifting from sustained release to enhancing penetration into cartilage[J]. DRUG DELIVERY,2022,29(1):767-791.
APA	Huang, Huirong., Lou, Zijian., Zheng, Shimin., Wu, Jianing., Yao, Qing., ... & Chen, Daosen. (2022). Intra-articular drug delivery systems for osteoarthritis therapy: shifting from sustained release to enhancing penetration into cartilage. DRUG DELIVERY, 29(1), 767-791.
MLA	Huang, Huirong,et al."Intra-articular drug delivery systems for osteoarthritis therapy: shifting from sustained release to enhancing penetration into cartilage".DRUG DELIVERY 29.1(2022):767-791.