LncRNA SOCS2-AS1 inhibits progression and metastasis of colorectal cancer through stabilizing SOCS2 and sponging miR-1264

doi:10.18632/aging.103276

科研成果详情

题名	LncRNA SOCS2-AS1 inhibits progression and metastasis of colorectal cancer through stabilizing SOCS2 and sponging miR-1264
作者	Zheng, Zhihai1; Li, Xiaoxiao 2; You, Heyi1; Zheng, Xiaofeng3; Ruan, Xiaojiao3
发表日期	2020-06-15
发表期刊	AGING-US 影响因子和分区
语种	英语
原始文献类型	Article
关键词	colorectal cancer SOCS2-AS1 miR-1264 SOCS2 progression
其他关键词	LONG NONCODING RNA ; LUNG-CANCER ; PROMOTES ; APOPTOSIS ; PROLIFERATION ; CARCINOMA ; CELLS
摘要	Abnormal expression of long noncoding RNA (lncRNA) is involved in human cancers, including colorectal cancer (CRC). However, their functional mechanism is largely unknown. In this study, we explored the roles of lncRNA SOCS2-AS1 in modulating CRC progression. We showed that SOCS2-AS1 was lowly expressed in CRC tissues and cells. SOCS2-AS1 downregulation predicted a poor prognosis in patients with CRC. SOCS2-AS1 overexpression significantly suppressed CRC cell proliferation, colony formation, EdU incorporation, cell-cycle, migration and invasion in vitro while SOCS2-AS1 knockdown led to an opposite phenotype. SOCS2-AS1 overexpression inhibited CRC growth and metastasis in vivo. Mechanistically, we discovered that SOCS2-AS1 was positively correlated with SOCS2 expression in CRC tissues. SOCS2-AS1 contributes to SOCS2 expression through restraining miR-1264. Additionally, we showed that SOCS2 silencing abrogated the suppressive effects of SOCS2-AS1 overexpression. Taken together, our results identified a novel regulatory loop in which SOCS2-AS1/miR-1264/SOCS2 axis suppresses CRC progression.
资助项目	Wenzhou Municipal Science and Technology Bureau [Y20160053]
出版者	IMPACT JOURNALS LLC
出版地	ORCHARD PARK
ISSN	1945-4589
卷号	12 期号:11 页码:10517-10526
DOI	10.18632/aging.103276
页数	10
WOS类目	Cell Biology ; Geriatrics & Gerontology
WOS研究方向	Cell Biology ; Geriatrics & Gerontology
WOS记录号	WOS:000540580800038
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	32437330
PMC记录号	PMC7346041
SCOPUSEID	2-s2.0-85087096265
通讯作者地址	[Ruan, Xiaojiao]Department of Gastrointestinal Surgery,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
Scopus学科分类	Aging;Cell Biology
引用统计	被引频次：16[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/1209
专题	附属第一医院_肛肠外科附属第一医院_胃肠外科附属第一医院_血管外科
通讯作者	Ruan, Xiaojiao
作者单位	1.Department of Colorectal and Anal Surgery,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 2.Department of Vascular Surgery,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 3.Department of Gastrointestinal Surgery,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Zheng, Zhihai,Li, Xiaoxiao,You, Heyi,et al. LncRNA SOCS2-AS1 inhibits progression and metastasis of colorectal cancer through stabilizing SOCS2 and sponging miR-1264[J]. AGING-US,2020,12(11):10517-10526.
APA	Zheng, Zhihai, Li, Xiaoxiao, You, Heyi, Zheng, Xiaofeng, & Ruan, Xiaojiao. (2020). LncRNA SOCS2-AS1 inhibits progression and metastasis of colorectal cancer through stabilizing SOCS2 and sponging miR-1264. AGING-US, 12(11), 10517-10526.
MLA	Zheng, Zhihai,et al."LncRNA SOCS2-AS1 inhibits progression and metastasis of colorectal cancer through stabilizing SOCS2 and sponging miR-1264".AGING-US 12.11(2020):10517-10526.