Association between Ankylosing Spondylitis and the miR-146a and miR-499 Polymorphisms

doi:10.1371/journal.pone.0122055

科研成果详情

题名	Association between Ankylosing Spondylitis and the miR-146a and miR-499 Polymorphisms
作者	Xu, Hui Ying 1; Wang, Zhang Yang 1; Chen, Jing Feng 2; Wang, Tian Yang 2; Wang, Ling Ling 1; Tang, Li Li 1; Lin, Xian-yang 3; Zhang, Chun-wu3; Chen, Bi-cheng1
发表日期	2015-04-02
发表期刊	PLOS ONE 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	NF-KAPPA-B ; PERIPHERAL-BLOOD ; FUNCTIONAL POLYMORPHISM ; TNF-ALPHA ; MICRORNA ; EXPRESSION ; TOLL-LIKE-RECEPTOR-4 ; INFLAMMATION ; BIOMARKERS ; ARTHRITIS
摘要	miRNAs are small, non-coding RNAs that regulate the expression of multiple target genes at the post-transcriptional level. Single-nucleotide polymorphisms (SNPs) in miRNA sequences may alter miRNA expression and have been implicated in the pathogenesis of multiple forms of arthritis, including rheumatoid arthritis (RA) and osteoarthritis. The present study explored the association between ankylosing spondylitis (AS) and two single nucleotide polymorphisms (SNPs), miR-146a rs2910164G>C and miR-499 rs3746444T>C, in a Han Chinese population. A case-control study consisting of 102 subjects with AS and 105 healthy controls was designed. The two miRNA SNPs were identified by direct sequencing. Subsequently, their gene and genotype frequencies were compared with healthy controls. A significant difference was observed in the miR-146a rs2910164G>C SNP. The frequency of the G allele was markedly higher in the AS patients than in the healthy controls (P = 0.005, Pc = 0.01, OR = 1.787), and the frequency of the GG genotype was higher in AS patients than in controls (P = 0.014, Pc = 0.042, OR = 2.516). However, no significant association was found between the miR-499 rs3746444T>C variant and susceptibility to AS. This is the first study to address the association between the miR-146a rs2910164G>C and miR-499 rs3746444T>C polymorphisms and AS, and it suggests a potential pathogenic factor for AS. Further studies are needed to validate our findings in a larger series, as well as in other ethnic backgrounds.
资助项目	Technology Foundation of Zhejiang Province [2013C33173]; Zhejiang Provincial Undergraduate Scientific and Technological Innovation Project; Fresh Talent Program [2014R413014]; NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of General Medical Sciences (NIGMS) [P20GM103476] Funding Source: NIH RePORTER
出版者	PUBLIC LIBRARY SCIENCE
出版地	SAN FRANCISCO
ISSN	1932-6203
卷号	10 期号:4 页码:e0122055.
DOI	10.1371/journal.pone.0122055
页数	9
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
WOS记录号	WOS:000352139000076
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	25836258
PMC记录号	PMC4383612
SCOPUSEID	2-s2.0-84926615503
通讯作者地址	[Zhang, Chun-wu]Wenzhou Med Univ, Affiliated Hosp 1, Injury Orthopaed Tradit Chinese Med, Wenzhou 325000, Peoples R China.
Scopus学科分类	Multidisciplinary
引用统计	被引频次：44[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/11989
专题	第一临床医学院（信息与工程学院）、附属第一医院_外科学_外科实验室附属第一医院
通讯作者	Zhang, Chun-wu
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 1, Key Lab Surg, Wenzhou 325000, Peoples R China; 2.Wenzhou Med Univ, Affiliated Hosp 1, Dept Surg, Wenzhou 325000, Peoples R China; 3.Wenzhou Med Univ, Affiliated Hosp 1, Injury Orthopaed Tradit Chinese Med, Wenzhou 325000, Peoples R China
第一作者单位	第一临床医学院（信息与工程学院）、附属第一医院_外科学_外科实验室
通讯作者单位	附属第一医院
第一作者的第一单位	第一临床医学院（信息与工程学院）、附属第一医院_外科学_外科实验室
推荐引用方式 GB/T 7714	Xu, Hui Ying,Wang, Zhang Yang,Chen, Jing Feng,et al. Association between Ankylosing Spondylitis and the miR-146a and miR-499 Polymorphisms[J]. PLOS ONE,2015,10(4):e0122055..
APA	Xu, Hui Ying., Wang, Zhang Yang., Chen, Jing Feng., Wang, Tian Yang., Wang, Ling Ling., ... & Chen, Bi-cheng. (2015). Association between Ankylosing Spondylitis and the miR-146a and miR-499 Polymorphisms. PLOS ONE, 10(4), e0122055..
MLA	Xu, Hui Ying,et al."Association between Ankylosing Spondylitis and the miR-146a and miR-499 Polymorphisms".PLOS ONE 10.4(2015):e0122055..