An elevated Fibrosis-4 score is associated with poor clinical outcomes in patients with sepsis: an observational cohort study

doi:10.20452/pamw.15699

科研成果详情

题名	An elevated Fibrosis-4 score is associated with poor clinical outcomes in patients with sepsis: an observational cohort study
作者	Zhu, Xiaodan1; Hu, Xiang2; Qin, Xiaoyi3; Pan, Jingye1; Zhou, Wei 1
发表日期	2020-12-22
发表期刊	POLISH ARCHIVES OF INTERNAL MEDICINE-POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ 影响因子和分区
语种	英语
原始文献类型	Article
关键词	critical illness hepatic fibrosis liver fibrosis index outcome sepsis
其他关键词	SIMPLE NONINVASIVE INDEX ; NECROSIS-FACTOR-ALPHA ; FATTY LIVER-DISEASE ; ACUTE KIDNEY INJURY ; UNITED-STATES ; MORTALITY ; CIRRHOSIS ; RISK ; PREDICT ; BURDEN
摘要	INTRODUCTION So far, no study has investigated the association between subclinical hepatic fibrosis and sepsis, especially in terms of prognosis. OBJECTIVES The purpose of our study was to explore the association of liver fibrosis indexes with the outcomes of septic patients without overt chronic liver disease. PATIENTS AND METHODS We performed a cohort study using data extracted from the Medical Information Mart for Intensive Care III (version 1.4) database. External validation was obtained from the First Affiliated Hospital of Wenzhou Medical University, China. We calculated the Aspartate Aminotransferase-to-Platelet Ratio Index, the Fibrosis-4 (FIB-4) score, and the Nonalcoholic Fatty Liver Disease Fibrosis Score using the existing formulas. The primary outcome was 28-day mortality. We assessed the associations of these 3 indexes with patient outcomes using logistic regression analysis. RESULTS In the FIB-4 sepsis cohort (n = 1560), there was a significant stepwise increase from quartile 1 to quartile 4 in the risk of 28-day mortality (quartile 1: reference; quartile 2: odds ratio [OR], 1.57, P = 0.06, 95% CI, 0.98-2.515; quartile 3: OR, 2.363, P < 0.001, 95% CI, 1.512-3.692; quartile 4: OR, 2.933, P < 0.001, 95% CI, 1.895-4.538). The results of multivariable regression, Kaplan-Meier, and Cox regression analyses as well as external validation exhibited good consistency. CONCLUSIONS The FIB-4 index is associated with 28-day, 90-day, and in-hospital mortality as well as with renal replacement therapy in septic patients without overt chronic liver disease. In other words, an advanced stage of subclinical hepatic fibrosis as represented by the FIB-4 score indicates poor outcomes in patients with sepsis.
资助项目	Research Incubation Project of the First Affiliated Hospital of Wenzhou Medical University [FHY2019088]
出版者	MEDYCYNA PRAKTYCZNA SP K SP ZOO
出版地	KRAKOW
ISSN	0032-3772
EISSN	1897-9483
卷号	130 期号:12 页码:1064-1073
DOI	10.20452/pamw.15699
页数	10
WOS类目	Medicine, General & Internal
WOS研究方向	General & Internal Medicine
WOS记录号	WOS:000603351500007
收录类别	SCIE ; SCOPUS
URL	查看原文
PubMed ID	33274619
SCOPUSEID	2-s2.0-85098062995
通讯作者地址	[Zhou, Wei]Department of Intensive Care Unit,The First Affiliated Hospital of Wenzhou Medical University,Nan Bai Xiang Street,Ouhai District, Wenzhou, Zhejiang,325000,China
Scopus学科分类	Internal Medicine
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/1196
专题	附属第一医院
通讯作者	Zhou, Wei
作者单位	1.Department of Intensive Care Unit,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang,China; 2.Department of Endocrine and Metabolic Diseases,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang,China; 3.Department of Hematology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang,China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Zhu, Xiaodan,Hu, Xiang,Qin, Xiaoyi,et al. An elevated Fibrosis-4 score is associated with poor clinical outcomes in patients with sepsis: an observational cohort study[J]. POLISH ARCHIVES OF INTERNAL MEDICINE-POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ,2020,130(12):1064-1073.
APA	Zhu, Xiaodan, Hu, Xiang, Qin, Xiaoyi, Pan, Jingye, & Zhou, Wei. (2020). An elevated Fibrosis-4 score is associated with poor clinical outcomes in patients with sepsis: an observational cohort study. POLISH ARCHIVES OF INTERNAL MEDICINE-POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ, 130(12), 1064-1073.
MLA	Zhu, Xiaodan,et al."An elevated Fibrosis-4 score is associated with poor clinical outcomes in patients with sepsis: an observational cohort study".POLISH ARCHIVES OF INTERNAL MEDICINE-POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ 130.12(2020):1064-1073.