题名 | Ferroptosis, a new form of cell death, and its relationships with tumourous diseases |
作者 | |
发表日期 | 2017-04 |
发表期刊 | JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Review |
关键词 | ferroptosis iron-dependent cell death tumourous diseases erastin |
其他关键词 | HEPATOCELLULAR-CARCINOMA CELLS ; HEAT-SHOCK PROTEINS ; CYSTINE/GLUTAMATE ANTIPORTER ; IN-VITRO ; TRANSSULFURATION PATHWAY ; LYMPHOMA GROWTH ; CANCER ; IRON ; SORAFENIB ; CYSTINE |
摘要 | Ferroptosis is a newly discovered type of cell death that differs from traditional apoptosis and necrosis and results from iron-dependent lipid peroxide accumulation. Ferroptotic cell death is characterized by cytological changes, including cell volume shrinkage and increased mitochondrial membrane density. Ferroptosis can be induced by two classes of small-molecule substances known as class 1 (system X-c(-) inhibitors) and class 2 ferroptosis inducers [glutathione peroxidase 4 (GPx4) inhibitors]. In addition to these small-molecule substances, a number of drugs (e.g. sorafenib, artemisinin and its derivatives) can induce ferroptosis. Various factors, such as the mevalonate (MVA) and sulphur-transfer pathways, play pivotal roles in the regulation of ferroptosis. Ferroptosis plays an unneglectable role in regulating the growth and proliferation of some types of tumour cells, such as lymphocytoma, ductal cell cancer of the pancreas, renal cell carcinoma (RCC) and hepatocellular carcinoma (HCC). Here, we will first introduce the discovery of and research pertaining to ferroptosis; then summarize the induction mechanisms and regulatory pathways of ferroptosis; and finally, further elucidate the roles of ferroptosis in human tumourous diseases. |
出版者 | WILEY |
出版地 | HOBOKEN |
ISSN | 1582-1838 |
EISSN | 1582-4934 |
卷号 | 21期号:4页码:648-657 |
DOI | 10.1111/jcmm.13008 |
页数 | 10 |
WOS类目 | Cell Biology ; Medicine, Research & Experimental |
WOS研究方向 | Cell Biology ; Research & Experimental Medicine |
WOS记录号 | WOS:000399310800003 |
收录类别 | SCIE ; PUBMED ; SCOPUS |
URL | 查看原文 |
PubMed ID | 27860262 |
PMC记录号 | PMC5345622 |
SCOPUSEID | 2-s2.0-85000658863 |
ESI高被引论文 | 2022-07 ; 2022-09 ; 2022-11 ; 2023-01 ; 2023-03 ; 2023-05 ; 2023-07 ; 2023-09 ; 2023-11 ; 2024-01 ; 2024-03 ; 2024-05 ; 2024-07 ; 2024-09 |
通讯作者地址 | [Chen, Gang]Department of Hepatobiliary Surgery,The First Affiliated Hospital,Wenzhou Medical University,Wenzhou,China |
Scopus学科分类 | Molecular Medicine;Cell Biology |
TOP期刊 | TOP期刊 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/11954 |
专题 | 附属第一医院 仁济学院_环境与公共卫生学部 |
通讯作者 | Chen, Gang |
作者单位 | 1.Department of Hepatobiliary Surgery,The First Affiliated Hospital,Wenzhou Medical University,Wenzhou,China; 2.Environmental and Public Health School of Wenzhou Medical University,Wenzhou,China |
第一作者单位 | 附属第一医院 |
通讯作者单位 | 附属第一医院 |
第一作者的第一单位 | 附属第一医院 |
推荐引用方式 GB/T 7714 | Yu, Haitao,Guo, Pengyi,Xie, Xiaozai,et al. Ferroptosis, a new form of cell death, and its relationships with tumourous diseases[J]. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,2017,21(4):648-657. |
APA | Yu, Haitao, Guo, Pengyi, Xie, Xiaozai, Wang, Yi, & Chen, Gang. (2017). Ferroptosis, a new form of cell death, and its relationships with tumourous diseases. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 21(4), 648-657. |
MLA | Yu, Haitao,et al."Ferroptosis, a new form of cell death, and its relationships with tumourous diseases".JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 21.4(2017):648-657. |
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