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题名Ferroptosis, a new form of cell death, and its relationships with tumourous diseases
作者
发表日期2017-04
发表期刊JOURNAL OF CELLULAR AND MOLECULAR MEDICINE   影响因子和分区
语种英语
原始文献类型Review
关键词ferroptosis iron-dependent cell death tumourous diseases erastin
其他关键词HEPATOCELLULAR-CARCINOMA CELLS ; HEAT-SHOCK PROTEINS ; CYSTINE/GLUTAMATE ANTIPORTER ; IN-VITRO ; TRANSSULFURATION PATHWAY ; LYMPHOMA GROWTH ; CANCER ; IRON ; SORAFENIB ; CYSTINE
摘要

Ferroptosis is a newly discovered type of cell death that differs from traditional apoptosis and necrosis and results from iron-dependent lipid peroxide accumulation. Ferroptotic cell death is characterized by cytological changes, including cell volume shrinkage and increased mitochondrial membrane density. Ferroptosis can be induced by two classes of small-molecule substances known as class 1 (system X-c(-) inhibitors) and class 2 ferroptosis inducers [glutathione peroxidase 4 (GPx4) inhibitors]. In addition to these small-molecule substances, a number of drugs (e.g. sorafenib, artemisinin and its derivatives) can induce ferroptosis. Various factors, such as the mevalonate (MVA) and sulphur-transfer pathways, play pivotal roles in the regulation of ferroptosis. Ferroptosis plays an unneglectable role in regulating the growth and proliferation of some types of tumour cells, such as lymphocytoma, ductal cell cancer of the pancreas, renal cell carcinoma (RCC) and hepatocellular carcinoma (HCC). Here, we will first introduce the discovery of and research pertaining to ferroptosis; then summarize the induction mechanisms and regulatory pathways of ferroptosis; and finally, further elucidate the roles of ferroptosis in human tumourous diseases.

出版者WILEY
出版地HOBOKEN
ISSN1582-1838
EISSN1582-4934
卷号21期号:4页码:648-657
DOI10.1111/jcmm.13008
页数10
WOS类目Cell Biology ; Medicine, Research & Experimental
WOS研究方向Cell Biology ; Research & Experimental Medicine
WOS记录号WOS:000399310800003
收录类别SCIE ; PUBMED ; SCOPUS
URL查看原文
PubMed ID27860262
PMC记录号PMC5345622
SCOPUSEID2-s2.0-85000658863
ESI高被引论文2022-07 ; 2022-09 ; 2022-11 ; 2023-01 ; 2023-03 ; 2023-05 ; 2023-07 ; 2023-09 ; 2023-11 ; 2024-01 ; 2024-03 ; 2024-05 ; 2024-07 ; 2024-09
通讯作者地址[Chen, Gang]Department of Hepatobiliary Surgery,The First Affiliated Hospital,Wenzhou Medical University,Wenzhou,China
Scopus学科分类Molecular Medicine;Cell Biology
TOP期刊TOP期刊
引用统计
被引频次:270[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/11954
专题附属第一医院
仁济学院_环境与公共卫生学部
通讯作者Chen, Gang
作者单位
1.Department of Hepatobiliary Surgery,The First Affiliated Hospital,Wenzhou Medical University,Wenzhou,China;
2.Environmental and Public Health School of Wenzhou Medical University,Wenzhou,China
第一作者单位附属第一医院
通讯作者单位附属第一医院
第一作者的第一单位附属第一医院
推荐引用方式
GB/T 7714
Yu, Haitao,Guo, Pengyi,Xie, Xiaozai,et al. Ferroptosis, a new form of cell death, and its relationships with tumourous diseases[J]. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,2017,21(4):648-657.
APA Yu, Haitao, Guo, Pengyi, Xie, Xiaozai, Wang, Yi, & Chen, Gang. (2017). Ferroptosis, a new form of cell death, and its relationships with tumourous diseases. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 21(4), 648-657.
MLA Yu, Haitao,et al."Ferroptosis, a new form of cell death, and its relationships with tumourous diseases".JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 21.4(2017):648-657.

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