Development and validation of a ferroptosis-related model for three digestive tract tumors based on a pan-cancer analysis

doi:10.2217/epi-2021-0261

科研成果详情

题名	Development and validation of a ferroptosis-related model for three digestive tract tumors based on a pan-cancer analysis
作者	Zhang, Zhongjing 1; Papa Akuetteh, Percy David 2; Lin, Leilei3; Wu, Yiyang 4; Li, Yimeng 5; Huang, Weiguo 1; Ni, Haizhen1; Lv, Heping1; Zhang, Qiyu2
发表日期	2021-09
发表期刊	EPIGENOMICS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	cholangiocarcinoma ferroptosis genes ferroptosis phenotype-related genes liver hepatocellular carcinoma pan-cancer analysis pancreatic adenocarcinoma The Cancer Genome Atlas
其他关键词	EXPRESSION ; PROGRESSION ; RESISTANCE ; CELLS
摘要	Aims: To develop a ferroptosis gene-based survival-predictor model for predicting the prognosis of patients with digestive tract tumors, a pan-caner analysis was performed. Materials & methods: Based on unsupervised clustering and the expression levels of ferroptosis genes, patients with cancer were divided into two clusters. The least absolute shrinkage and selection operator method Cox regression analysis was used to establish the survival-predictor model. Results: Based on the pan-cancer analysis, a 20 gene-based survival-predictor model for predicting survival rates was developed, which was validated in patients with hepatocellular carcinoma. Conclusion: The survival-predictor model accurately predicted the prognosis of patients with digestive tract tumors.
出版者	FUTURE MEDICINE LTD
出版地	LONDON
ISSN	1750-1911
EISSN	1750-192X
卷号	13 期号:18 页码:1497-1514
DOI	10.2217/epi-2021-0261
页数	18
WOS类目	Genetics & Heredity
WOS研究方向	Genetics & Heredity
WOS记录号	WOS:000700578700001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	34581636
SCOPUSEID	2-s2.0-85117903548
通讯作者地址	[Ni, Haizhen]Department of Vascular Surgery,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou Zhejiang Province,325015,China
Scopus学科分类	Genetics;Cancer Research
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/11843
专题	附属第一医院_血管外科第一临床医学院（信息与工程学院）、附属第一医院附属第二医院附属第一医院第二临床医学院、附属第二医院、育英儿童医院
通讯作者	Ni, Haizhen
作者单位	1.Department of Vascular Surgery,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou Zhejiang Province,325015,China; 2.Department of Hepatopancreatobiliary Surgery,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou Zhejiang Province,325015,China; 3.First School of Clinical Medicine,Wenzhou Medical University,Wenzhou Zhejiang Province,325000,China; 4.Department of Hepatobiliary Surgery,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou,325000,China; 5.Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases,The First Affiliated Hospital,Wenzhou Medical University,Zhejiang Province,325015,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Zhang, Zhongjing,Papa Akuetteh, Percy David,Lin, Leilei,et al. Development and validation of a ferroptosis-related model for three digestive tract tumors based on a pan-cancer analysis[J]. EPIGENOMICS,2021,13(18):1497-1514.
APA	Zhang, Zhongjing., Papa Akuetteh, Percy David., Lin, Leilei., Wu, Yiyang., Li, Yimeng., ... & Zhang, Qiyu. (2021). Development and validation of a ferroptosis-related model for three digestive tract tumors based on a pan-cancer analysis. EPIGENOMICS, 13(18), 1497-1514.
MLA	Zhang, Zhongjing,et al."Development and validation of a ferroptosis-related model for three digestive tract tumors based on a pan-cancer analysis".EPIGENOMICS 13.18(2021):1497-1514.