Peptidomimetic suppresses proliferation and invasion of gastric cancer cells by fibroblast growth factor 2 signaling cascade blockage

doi:10.1097/CAD.0000000000000312

科研成果详情

题名	Peptidomimetic suppresses proliferation and invasion of gastric cancer cells by fibroblast growth factor 2 signaling cascade blockage
作者	Li, Wulan1,2; Du, Xiaojing4; Chen, Qiuxiang1,4; Kang, Yanting 1,4; Xu, Chaochao 1,4; Fan, Lei 1; Ye, Hui3; Ying, Shilong 1; Shi, Lingyi 1; Jin, Rong4,5; Wu, Jianzhang1; Liang, Guang1; Li, Xiaokun1
发表日期	2016-03
发表期刊	ANTI-CANCER DRUGS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	FGF FGFR gastric cancer invasion proliferation target therapy
其他关键词	HEPARANASE INHIBITOR PI-88 ; THERAPEUTIC TARGET ; LUNG-CANCER ; EXPRESSION ; CARCINOMA ; PEPTIDE ; ANTAGONIST ; RECEPTORS ; VEGF
摘要	Fibroblast growth factor 2 (FGF2) is closely involved in a variety of tumors, including gastric cancer (GC). FGF2 inhibitors exert good antitumor activity, but no FGF2 inhibitor has been employed for clinical use. To obtain a low-toxicity, stable peptidomimetic (called P29) target to FGF2, the affinity between P29 and FGF2 was detected by surface plasmon resonance. The stability of P29 was measured by high performance liquid chromatography. MTT assay and transwell assay were used to access the proliferative and invasive ability of GC cells, respectively. Western blot assay and flow cytometric analysis were applied to study the mechanism of P29. P29 possessed high affinity with FGF2 and a longer half-life in vitro. P29 suppressed the FGF2-induced proliferation of GC cells. It also inhibited the phosphorylation of FRS2, ERK1/2, and AKT triggered by FGF2 in GC. In addition, P29 blocked GC cell transformation from the G1/G0 phase to the S phase and weakened the invasive capability of GC cells. In this paper, we present a novel FGF2 inhibitor that could exert improved anticancer effect in GC in vitro.
资助项目	ZheJiang Province Natural Science Funding of China [LY14H160044, Y4110029, LY13H160022]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81402839, 81102310]; Technology Foundation for Medical Science of Zhejiang Province [2012KYB127]
出版者	LIPPINCOTT WILLIAMS & WILKINS
出版地	PHILADELPHIA
ISSN	0959-4973
EISSN	1473-5741
卷号	27 期号:3 页码:164-172
DOI	10.1097/CAD.0000000000000312
页数	9
WOS类目	Oncology ; Pharmacology & Pharmacy
WOS研究方向	Oncology ; Pharmacology & Pharmacy
WOS记录号	WOS:000373515300003
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	26556626
SCOPUSEID	2-s2.0-84957937122
通讯作者地址	[Jin, Rong]Department of Digestive Diseases,First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang,323000,China
Scopus学科分类	Oncology;Pharmacology;Pharmacology (medical);Cancer Research
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/11778
专题	药学院（分析测试中心）_生物有机与药物化学研究中心温州医科大学基础医学院（机能实验教学中心）附属第一医院
通讯作者	Jin, Rong
作者单位	1.Chemical Biology Research Center,College of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou, Zhejiang,China; 2.College of Information Science and Computer Engineering,Wenzhou Medical University,Wenzhou, Zhejiang,China; 3.School of Basic Medical Sciences,Wenzhou Medical University,Wenzhou, Zhejiang,China; 4.Department of Digestive Diseases,First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang,323000,China; 5.Department of Epidemiology,First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang,China
第一作者单位	药学院（分析测试中心）_生物有机与药物化学研究中心; 温州医科大学
通讯作者单位	附属第一医院
第一作者的第一单位	药学院（分析测试中心）_生物有机与药物化学研究中心
推荐引用方式 GB/T 7714	Li, Wulan,Du, Xiaojing,Chen, Qiuxiang,et al. Peptidomimetic suppresses proliferation and invasion of gastric cancer cells by fibroblast growth factor 2 signaling cascade blockage[J]. ANTI-CANCER DRUGS,2016,27(3):164-172.
APA	Li, Wulan., Du, Xiaojing., Chen, Qiuxiang., Kang, Yanting., Xu, Chaochao., ... & Li, Xiaokun. (2016). Peptidomimetic suppresses proliferation and invasion of gastric cancer cells by fibroblast growth factor 2 signaling cascade blockage. ANTI-CANCER DRUGS, 27(3), 164-172.
MLA	Li, Wulan,et al."Peptidomimetic suppresses proliferation and invasion of gastric cancer cells by fibroblast growth factor 2 signaling cascade blockage".ANTI-CANCER DRUGS 27.3(2016):164-172.