题名 | AKT1/HK2 Axis-mediated Glucose Metabolism: A Novel Therapeutic Target of Sulforaphane in Bladder Cancer |
作者 | |
发表期刊 | MOLECULAR NUTRITION & FOOD RESEARCH 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article |
关键词 | aerobic glycolysis bladder cancer glucose metabolism glycolysis sulforaphane |
其他关键词 | MESENCHYMAL TRANSITION ; PROGRESSION |
摘要 | Scope Metabolic disorder is a pivotal hallmark of cancer cells. Sulforaphane (SFN) is reported to improve lipid metabolism. However, the effect of SFN on glucose metabolism in bladder cancer remains unclear. Hence, the effect and underling mechanism is investigated. Methods and Results Biological samples from bladder cancer patients are collected, and also investigated using N-butyl-N-(4-hydroxybutyl) nitrosamine-induced bladder cancer mice and bladder cancer cell lines. A novel glucose transport aberrant-independent aerobic glycolysis is found in bladder cancer patients, and the lower malignancy tissues have the more obvious abnormality. SFN strongly downregulates ATP production by inhibiting glycolysis and mitochondrial oxidative phosphorylation (OXPHOS). Both in vitro cell culture and in bladder tumor mice, SFN weaken the glycolytic flux by suppressing multiple metabolic enzymes, including hexokinase 2 (HK2) and pyruvate dehydrogenase (PDH). Moreover, SFN decreases the level of AKT1 and p-AKT (ser473), especially in low-invasive UMUC3 cells. The downregulation of ATP and HK2 by SFN is both reversed by AKT1 overexpression. Conclusions SFN downregulates the unique glucose transport aberrant-independent aerobic glycolysis existed in bladder cancer via blocking the AKT1/HK2 axis and PDH expression. |
资助项目 | National Natural Science Foundation of China (NSFC)National Natural Science Foundation of China (NSFC) [81773427] |
出版者 | WILEY |
出版地 | HOBOKEN |
ISSN | 1613-4125 |
EISSN | 1613-4133 |
卷号 | 66期号:3页码:e2100738. |
DOI | 10.1002/mnfr.202100738 |
WOS类目 | Food Science & Technology |
WOS研究方向 | Food Science & Technology |
WOS记录号 | WOS:000727367900001 |
收录类别 | SCIE ; SCOPUS ; PUBMED |
发表日期 | 2022-02 |
URL | 查看原文 |
Pubmed记录号 | 34791822 |
Scopus记录号 | 2-s2.0-85120457528 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/11318 |
专题 | 公共卫生与管理学院 |
通讯作者 | Ren, Minghua; Shan, Yujuan |
作者单位 | 1.Wenzhou Med Univ, Sch Publ Hlth & Management, Wenzhou 325000, Peoples R China; 2.Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Boston, MA 02139 USA; 3.Ningbo Univ, Sch Med, Inst Preventat Med, Ningbo 315211, Peoples R China; 4.Ningbo Univ, Sch Med, Zhejiang Prov Key Lab Pathol & Physiol Technol, Ningbo 315211, Peoples R China; 5.Harbin Med Univ, Dept Urol, Affiliated Hosp 1, Harbin 150001, Peoples R China |
第一作者单位 | 公共卫生学院 |
通讯作者单位 | 公共卫生学院 |
第一作者的第一单位 | 公共卫生学院; 公共卫生学院 |
推荐引用方式 GB/T 7714 | Huang, Lei,He, Canxia,Zheng, Sicong,et al. AKT1/HK2 Axis-mediated Glucose Metabolism: A Novel Therapeutic Target of Sulforaphane in Bladder Cancer[J]. MOLECULAR NUTRITION & FOOD RESEARCH,2022,66(3):e2100738.. |
APA | Huang, Lei, He, Canxia, Zheng, Sicong, Wu, Chao, Ren, Minghua, & Shan, Yujuan. (2022). AKT1/HK2 Axis-mediated Glucose Metabolism: A Novel Therapeutic Target of Sulforaphane in Bladder Cancer. MOLECULAR NUTRITION & FOOD RESEARCH, 66(3), e2100738.. |
MLA | Huang, Lei,et al."AKT1/HK2 Axis-mediated Glucose Metabolism: A Novel Therapeutic Target of Sulforaphane in Bladder Cancer".MOLECULAR NUTRITION & FOOD RESEARCH 66.3(2022):e2100738.. |
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