Targeting endoplasmic reticulum stress in liver disease

doi:10.1080/17474124.2016.1179575

科研成果详情

题名	Targeting endoplasmic reticulum stress in liver disease
作者	Wu, Fa-Ling1,2; Liu, Wen-Yue3; Van Poucke, Sven 4; Braddock, Martin 5; Jin, Wei-Min 6; Xiao, Jian7,8; Li, Xiao-Kun7,8; Zheng, Ming-Hua1,2
发表日期	2016-12-31
发表期刊	EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY 影响因子和分区
语种	英语
原始文献类型	Review
关键词	Endoplasmic reticulum stress alcoholic liver disease nonalcoholic fatty liver disease drug-induced liver injury acute-on-chronic liver failure hepatocellular carcinoma therapeutic target
其他关键词	UNFOLDED PROTEIN RESPONSE ; HEPATITIS-C VIRUS ; HUMAN HEPATOCELLULAR-CARCINOMA ; GROWTH-FACTOR 21 ; ELEMENT-BINDING PROTEIN-2 ; HIGH-FAT DIET ; NF-KAPPA-B ; ER STRESS ; POSSIBLE INVOLVEMENT ; BAICALEIN PROTECTS
摘要	Introduction: The accumulation of unfolded protein in the endoplasmic reticulum (ER) initiates an unfolded protein response (UPR) via three signal transduction cascades, which involve protein kinase RNA-like ER kinase (PERK), inositol requiring enzyme-1 alpha (IRE1 alpha) and activating transcription factor-6 alpha (ATF6 alpha). An ER stress response is observed in nearly all physiologies related to acute and chronic liver disease and therapeutic targeting of the mechanisms implicated in UPR signaling have attracted considerable attention. Areas covered: This review focuses on the correlation between ER stress and liver disease and the possible targets which may drive the potential for novel therapeutic intervention. Expert Commentary: We describe pathways which are involved in UPR signaling and their potential correlation with various liver diseases and underlying mechanisms which may present opportunities for novel therapeutic strategies are discussed.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81500665]; Health Bureau of Zhejiang Province [2010KYB070]; Research Foundation of Education Bureau of Zhejiang Province [Y201009942]; Project of New Century 551 Talent Nurturing in Wenzhou
出版者	TAYLOR & FRANCIS LTD
出版地	ABINGDON
ISSN	1747-4124
EISSN	1747-4132
卷号	10 期号:9 页码:1041-1052
DOI	10.1080/17474124.2016.1179575
页数	12
WOS类目	Gastroenterology & Hepatology
WOS研究方向	Gastroenterology & Hepatology
WOS记录号	WOS:000384644600008
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	27093595
SCOPUSEID	2-s2.0-84965050646
通讯作者地址	[Zheng, Ming-Hua]Department of Hepatology,Liver Research Center,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Hepatology;Gastroenterology
引用统计	被引频次：26[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/10819
专题	附属第一医院药学院（分析测试中心）附属第一医院_感染内科
通讯作者	Zheng, Ming-Hua
作者单位	1.Department of Hepatology,Liver Research Center,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.Institute of Hepatology,Wenzhou Medical University,Wenzhou,China; 3.Department of Endocrinology,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 4.Department of Anesthesiology,Intensive Care,Emergency Medicine and Pain Therapy,Ziekenhuis Oost-Limburg,Genk,Belgium; 5.Global Medicines Development,AstraZeneca R&D,Alderley Park,United Kingdom; 6.Department of Infection Diseases,People Hospital of Wencheng County,Wenzhou,China; 7.Institute of Biology Science,Wenzhou University,Wenzhou,China; 8.School of Pharmacy,Wenzhou Medical University,Wenzhou,China
第一作者单位	附属第一医院; 附属第一医院_感染内科
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Wu, Fa-Ling,Liu, Wen-Yue,Van Poucke, Sven,et al. Targeting endoplasmic reticulum stress in liver disease[J]. EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY,2016,10(9):1041-1052.
APA	Wu, Fa-Ling., Liu, Wen-Yue., Van Poucke, Sven., Braddock, Martin., Jin, Wei-Min., ... & Zheng, Ming-Hua. (2016). Targeting endoplasmic reticulum stress in liver disease. EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY, 10(9), 1041-1052.
MLA	Wu, Fa-Ling,et al."Targeting endoplasmic reticulum stress in liver disease".EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY 10.9(2016):1041-1052.