MiR-187 overexpression inhibits cervical cancer progression by targeting HPV16 E6

doi:10.18632/oncotarget.17516

科研成果详情

题名	MiR-187 overexpression inhibits cervical cancer progression by targeting HPV16 E6
作者	Lin, Mao 1; Xue, Xiang-Yang2; Liang, Shu-Zhen 1; Li, Yin-Xiong 3; Lv, You-Yong 4; He, Li-Hua 1; Xu, Ke-Cheng 1; Zhang, Li-Fang 2; Chen, Ji-Bing 1; Niu, Li-Zhi 1
发表日期	2017-09-08
发表期刊	ONCOTARGET 影响因子和分区
语种	英语
原始文献类型	Article
关键词	microRNA-187 HPV16 E6 cervical cancer occurrence progression
其他关键词	SQUAMOUS-CELL CARCINOMA ; STOMATIN-LIKE PROTEIN-2 ; MICRORNA EXPRESSION ; BREAST-CANCER ; PROGNOSTIC-SIGNIFICANCE ; DOWN-REGULATION ; PATTERNS ; BURDEN ; ADENOCARCINOMA ; PROLIFERATION
摘要	Aberrantly expressed microRNAs contribute to the initiation and progression of human cancer. MiRNA-187 has been reported in nasopharyngeal, renal, pancreatic, prostate, and esophageal cancer, and acts as a tumor suppressor or oncogene. However, the underlying function of miRNA-187 in cervical cancer remains largely unexplored. In the present study, we demonstrated significantly miRNA-187 down-regulation in cervical cancer tissues and cell lines compared to their normal counterparts. Kaplan-Meier analysis revealed that decreased miRNA-187 was closely associated with shorter overall survival and relapse-free survival. Gain-and loss-of-function studies showed that miRNA-187 suppressed cervical cancer cell proliferation, migration, and invasion, and promoted cervical cancer cell apoptosis. Furthermore, luciferase reporter assay determined that human papillomavirus 16 E6 was a direct functional target of miRNA-187. Taken together, our findings indicate the essential role of miRNA-187 in suppressing cervical cancer progression and indicate a novel link between miRNA-187 and human papillomavirus 16 E6 in cervical cancer.
资助项目	Innovative Talents Plan of Guangzhou, China [201402003]; Wenzhou Medical University [H20100013]
出版者	IMPACT JOURNALS LLC
出版地	ORCHARD PARK
ISSN	1949-2553
EISSN	1949-2553
卷号	8 期号:38 页码:62914-62926
DOI	10.18632/oncotarget.17516
页数	13
WOS类目	Oncology ; Cell Biology
WOS研究方向	Oncology ; Cell Biology
WOS记录号	WOS:000410284800010
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
Pubmed记录号	28968959
PMC记录号	PMC5609891
Scopus记录号	2-s2.0-85029802144
通讯作者地址	[Chen, Ji-Bing]Fuda Cancer Hospital,Jinan University School of Medicine,Department of Central Laboratory,Guangzhou,China
scopus学科分类	Oncology
引用统计	被引频次：17[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/10714
专题	基础医学院（机能实验教学中心）_病原生物学与免疫学系_医学微生物学
通讯作者	Chen, Ji-Bing
作者单位	1.Fuda Cancer Hospital,Jinan University School of Medicine,Department of Central Laboratory,Guangzhou,China; 2.Wenzhou Medical University,Department of Immunology and Microbiology,Wenzhou,China; 3.Guangzhou Institute of Biomedicine and Healthy,Chinese Academy of Sciences,Guangzhou,China; 4.Peking University Cancer Hospital,Department of Central Laboratory,Beijing,China
推荐引用方式 GB/T 7714	Lin, Mao,Xue, Xiang-Yang,Liang, Shu-Zhen,et al. MiR-187 overexpression inhibits cervical cancer progression by targeting HPV16 E6[J]. ONCOTARGET,2017,8(38):62914-62926.
APA	Lin, Mao., Xue, Xiang-Yang., Liang, Shu-Zhen., Li, Yin-Xiong., Lv, You-Yong., ... & Niu, Li-Zhi. (2017). MiR-187 overexpression inhibits cervical cancer progression by targeting HPV16 E6. ONCOTARGET, 8(38), 62914-62926.
MLA	Lin, Mao,et al."MiR-187 overexpression inhibits cervical cancer progression by targeting HPV16 E6".ONCOTARGET 8.38(2017):62914-62926.