题名 | Clinical value of jointly detection pleural fluid Midkine, pleural fluid adenosine deaminase, and pleural fluid carbohydrate antigen 125 in the identification of nonsmall cell lung cancer-associated malignant pleural effusion |
作者 | |
发表日期 | 2018-10 |
发表期刊 | JOURNAL OF CLINICAL LABORATORY ANALYSIS 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article |
关键词 | adenosine deaminase malignant pleural effusion Midkine nonsmall cell lung cancer pleural fluid carbohydrate antigen 125 |
其他关键词 | SERUM MIDKINE ; DISEASES |
摘要 | BackgroundMethodsMidkine (MK) level has been shown to be elevated in serum of patients with nonsmall cell lung cancer (NSCLC). However, the diagnostic value of MK in pleural effusion in NSCLC has not been well validated and established. Samples of NSCLC-associated malignant pleural effusions (MPE) and benign effusions (BPE) were collected. The pleural fluid MK (pMK), pleural fluid adenosine deaminase (pADA), pleural fluid lactate dehydrogenase (pLDH), pleural fluid glucose (pGLU), pleural fluid ferritin (pFER), pleural fluid CA199 (pCA199), pleural fluid CA125 (pCA125), pleural effusion white cell count (pWBC), and pleural effusion red cell count (pRBC) were analyzed, and the clinical data of each group were collected for statistical analysis. ResultConclusionThe level of pMK, pCA125, pMK+pCA125, and pMK+pCA125+pADA in the MPE was significantly higher than the BPE group (P=.003, .000, .000, .000). The pADA level in the BPE was significantly higher than the MPE group (P=.003). It showed that the area under the ROC curve (AUC) (0.816) of jointly detection pMK, pCA125, and pADA was significantly higher than other markers for the diagnosis of MPE. Therefore, joint detection of pMK+pCA125+pADA suggested that the sensitivity, specificity, and AUC was 82.54%, 74.19% at the cutoff 0.47 and diagnostic performance was higher than others. Joint detection of pMK+pCA125+pADA can be used as a good indicator for the identification of MPE of NSCLC. |
资助项目 | National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81672088] Funding Source: Medline; Natural Science Foundation of Zhejiang ProvinceNatural Science Foundation of Zhejiang Province [LQ16H160020] Funding Source: Medline; The Wenzhou Municipal Science and Technology Bureau, China [Y20170208, Y20160160] Funding Source: Medline |
出版者 | WILEY |
出版地 | HOBOKEN |
ISSN | 0887-8013 |
EISSN | 1098-2825 |
卷号 | 32期号:8页码:e22576. |
DOI | 10.1002/jcla.22576 |
页数 | 5 |
WOS类目 | Medical Laboratory Technology |
WOS研究方向 | Medical Laboratory Technology |
WOS记录号 | WOS:000447772900014 |
收录类别 | SCIE ; PUBMED ; SCOPUS |
URL | 查看原文 |
PubMed ID | 29797475 |
PMC记录号 | PMC6817252 |
SCOPUSEID | 2-s2.0-85047604220 |
通讯作者地址 | [Jiang, Feng]Department of Laboratory Medicine,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China |
Scopus学科分类 | Immunology and Allergy;Hematology;Public Health, Environmental and Occupational Health;Clinical Biochemistry;Medical Laboratory Technology;Biochemistry (medical);Microbiology (medical) |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/1063 |
专题 | 附属第一医院 附属第一医院_重症医学科(ICU) |
通讯作者 | Jiang, Feng |
作者单位 | 1.Department of Laboratory Medicine,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.Department of ICU,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China |
第一作者单位 | 附属第一医院; 第一临床医学院(信息与工程学院)、附属第一医院 |
通讯作者单位 | 附属第一医院; 第一临床医学院(信息与工程学院)、附属第一医院 |
第一作者的第一单位 | 附属第一医院 |
推荐引用方式 GB/T 7714 | Zhang, Fan,Wang, Junjun,Zheng, Xiaoyong,et al. Clinical value of jointly detection pleural fluid Midkine, pleural fluid adenosine deaminase, and pleural fluid carbohydrate antigen 125 in the identification of nonsmall cell lung cancer-associated malignant pleural effusion[J]. JOURNAL OF CLINICAL LABORATORY ANALYSIS,2018,32(8):e22576.. |
APA | Zhang, Fan., Wang, Junjun., Zheng, Xiaoyong., Hu, Lijuan., Chen, Jie., ... & Wang, Yumin. (2018). Clinical value of jointly detection pleural fluid Midkine, pleural fluid adenosine deaminase, and pleural fluid carbohydrate antigen 125 in the identification of nonsmall cell lung cancer-associated malignant pleural effusion. JOURNAL OF CLINICAL LABORATORY ANALYSIS, 32(8), e22576.. |
MLA | Zhang, Fan,et al."Clinical value of jointly detection pleural fluid Midkine, pleural fluid adenosine deaminase, and pleural fluid carbohydrate antigen 125 in the identification of nonsmall cell lung cancer-associated malignant pleural effusion".JOURNAL OF CLINICAL LABORATORY ANALYSIS 32.8(2018):e22576.. |
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