科研成果详情

题名Clinical value of jointly detection pleural fluid Midkine, pleural fluid adenosine deaminase, and pleural fluid carbohydrate antigen 125 in the identification of nonsmall cell lung cancer-associated malignant pleural effusion
作者
发表日期2018-10
发表期刊JOURNAL OF CLINICAL LABORATORY ANALYSIS   影响因子和分区
语种英语
原始文献类型Article
关键词adenosine deaminase malignant pleural effusion Midkine nonsmall cell lung cancer pleural fluid carbohydrate antigen 125
其他关键词SERUM MIDKINE ; DISEASES
摘要BackgroundMethodsMidkine (MK) level has been shown to be elevated in serum of patients with nonsmall cell lung cancer (NSCLC). However, the diagnostic value of MK in pleural effusion in NSCLC has not been well validated and established. Samples of NSCLC-associated malignant pleural effusions (MPE) and benign effusions (BPE) were collected. The pleural fluid MK (pMK), pleural fluid adenosine deaminase (pADA), pleural fluid lactate dehydrogenase (pLDH), pleural fluid glucose (pGLU), pleural fluid ferritin (pFER), pleural fluid CA199 (pCA199), pleural fluid CA125 (pCA125), pleural effusion white cell count (pWBC), and pleural effusion red cell count (pRBC) were analyzed, and the clinical data of each group were collected for statistical analysis. ResultConclusionThe level of pMK, pCA125, pMK+pCA125, and pMK+pCA125+pADA in the MPE was significantly higher than the BPE group (P=.003, .000, .000, .000). The pADA level in the BPE was significantly higher than the MPE group (P=.003). It showed that the area under the ROC curve (AUC) (0.816) of jointly detection pMK, pCA125, and pADA was significantly higher than other markers for the diagnosis of MPE. Therefore, joint detection of pMK+pCA125+pADA suggested that the sensitivity, specificity, and AUC was 82.54%, 74.19% at the cutoff 0.47 and diagnostic performance was higher than others. Joint detection of pMK+pCA125+pADA can be used as a good indicator for the identification of MPE of NSCLC.
资助项目National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81672088] Funding Source: Medline; Natural Science Foundation of Zhejiang ProvinceNatural Science Foundation of Zhejiang Province [LQ16H160020] Funding Source: Medline; The Wenzhou Municipal Science and Technology Bureau, China [Y20170208, Y20160160] Funding Source: Medline
出版者WILEY
出版地HOBOKEN
ISSN0887-8013
EISSN1098-2825
卷号32期号:8页码:e22576.
DOI10.1002/jcla.22576
页数5
WOS类目Medical Laboratory Technology
WOS研究方向Medical Laboratory Technology
WOS记录号WOS:000447772900014
收录类别SCIE ; PUBMED ; SCOPUS
URL查看原文
PubMed ID29797475
PMC记录号PMC6817252
SCOPUSEID2-s2.0-85047604220
通讯作者地址[Jiang, Feng]Department of Laboratory Medicine,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类Immunology and Allergy;Hematology;Public Health, Environmental and Occupational Health;Clinical Biochemistry;Medical Laboratory Technology;Biochemistry (medical);Microbiology (medical)
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/1063
专题附属第一医院
附属第一医院_重症医学科(ICU)
通讯作者Jiang, Feng
作者单位
1.Department of Laboratory Medicine,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China;
2.Department of ICU,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
第一作者单位附属第一医院;  第一临床医学院(信息与工程学院)、附属第一医院
通讯作者单位附属第一医院;  第一临床医学院(信息与工程学院)、附属第一医院
第一作者的第一单位附属第一医院
推荐引用方式
GB/T 7714
Zhang, Fan,Wang, Junjun,Zheng, Xiaoyong,et al. Clinical value of jointly detection pleural fluid Midkine, pleural fluid adenosine deaminase, and pleural fluid carbohydrate antigen 125 in the identification of nonsmall cell lung cancer-associated malignant pleural effusion[J]. JOURNAL OF CLINICAL LABORATORY ANALYSIS,2018,32(8):e22576..
APA Zhang, Fan., Wang, Junjun., Zheng, Xiaoyong., Hu, Lijuan., Chen, Jie., ... & Wang, Yumin. (2018). Clinical value of jointly detection pleural fluid Midkine, pleural fluid adenosine deaminase, and pleural fluid carbohydrate antigen 125 in the identification of nonsmall cell lung cancer-associated malignant pleural effusion. JOURNAL OF CLINICAL LABORATORY ANALYSIS, 32(8), e22576..
MLA Zhang, Fan,et al."Clinical value of jointly detection pleural fluid Midkine, pleural fluid adenosine deaminase, and pleural fluid carbohydrate antigen 125 in the identification of nonsmall cell lung cancer-associated malignant pleural effusion".JOURNAL OF CLINICAL LABORATORY ANALYSIS 32.8(2018):e22576..

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