NIR-triggered upconversion nanoparticles@thermo-sensitive liposome hybrid theranostic nanoplatform for controlled drug delivery

doi:10.1039/d1ra04431a

科研成果详情

题名	NIR-triggered upconversion nanoparticles@thermo-sensitive liposome hybrid theranostic nanoplatform for controlled drug delivery
作者	Yu, Yibin 1,6; Huang, Yida 2; Feng, Wanqian3; Yang, Mei 2; Shao, Baiqi 1,6; Li, Jingjing 4; Ye, Fangfu 1,5,6
发表日期	2021-09-08
发表期刊	RSC ADVANCES 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Diagnosis Flavonoids Hyaluronic acid Infrared devices Liposomes Nanoparticles Noninvasive medical procedures Silica Silicon SiO2 nanoparticles Targeted drug delivery Theranostics Controlled release Non-invasive diagnostics Photo-thermal conversions Posterior segment Thermal-induced phase transitions Thermo sensitive Upconversion luminescence Upconversion nanoparticles
其他关键词	THERAPY ; MICROENVIRONMENT
摘要	Posterior segment ocular diseases are highly prevalent worldwide due to the lack of suitable noninvasive diagnostic and therapeutic tactics. Herein, concerning this predicament, we designed a hybrid retina-targeted photothermal theranostic nanoplatform (UCNPs@Bi@SiO2@GE HP-lips), based on the unique upconversion luminescence (UCL) imaging of upconversion nanoparticles (UCNPs), efficient photothermal conversion ability of Bi nanoparticles, and thermal-induced phase transition properties of the liposomes (lips). The nanoplatform was functionalized with penetratin (PNT) and hyaluronic acid (HA), to obtain retina-targeted liposomes (HP-lips). Lipophilic genistein (GE) was entrapped into the liposomes (GE HP-lips). An in vitro release study showed NIR irradiation could photothermally trigger controlled release of GE from the liposomal platform. Moreover, cellular uptake evaluation via UCL imaging demonstrated UCNPs@Bi@SiO2@GE HP-lips represented the brightest UCL, compared with other formulations, which is beneficial for the accurate evaluation of the prognosis and severity of angiogenesis-related posterior segment disorders. Therefore, UCNPs@Bi@SiO2@GE HP-lips exhibit promising potential as a theranostic nanoplatform for posterior segment ocular diseases.
资助项目	National Key Research and Development Program of China [2020YFA0908200]; Natural Science Foundation of Jilin Province [20200201106JC]; Wenzhou Institute, University of Chinese Academy of Sciences [WIUCASQD2020012]
出版者	ROYAL SOC CHEMISTRY
出版地	CAMBRIDGE
ISSN	2046-2069
EISSN	2046-2069
卷号	11 期号:46 页码:29065-29072
DOI	10.1039/d1ra04431a
页数	45
WOS类目	Chemistry, Multidisciplinary
WOS研究方向	Chemistry
WOS记录号	WOS:000696361100063
收录类别	SCIE ; EI ; SCOPUS ; PUBMED
EI入藏号	20213810922069
EI主题词	Controlled drug delivery
URL	查看原文
PubMed ID	35478587
SCOPUSEID	2-s2.0-85115131653
通讯作者地址	[Shao, Baiqi]Wenzhou Institute,University of the Chinese Academy of Sciences,Wenzhou,325001,China
Scopus学科分类	Chemistry (all);Chemical Engineering (all)
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/10507
专题	附属第二医院_科研中心
通讯作者	Shao, Baiqi
作者单位	1.Wenzhou Institute,University of the Chinese Academy of Sciences,Wenzhou,325001,China; 2.Institute of Advanced Materials for Nano-bio Applications,Wenzhou Medical University,Wenzhou,325027,China; 3.Scientific Research Center,Wenzhou Medical University,Wenzhou,325035,China; 4.State Key Laboratory of Rare Earth Resource Utilization,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun,130022,China; 5.Beijing National Laboratory for Condensed Matter Physics,Institute of Physics,Chinese Academy of Sciences,Beijing,100190,China; 6.Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine,Vision and Brain Health),Wenzhou,325001,China
推荐引用方式 GB/T 7714	Yu, Yibin,Huang, Yida,Feng, Wanqian,et al. NIR-triggered upconversion nanoparticles@thermo-sensitive liposome hybrid theranostic nanoplatform for controlled drug delivery[J]. RSC ADVANCES,2021,11(46):29065-29072.
APA	Yu, Yibin., Huang, Yida., Feng, Wanqian., Yang, Mei., Shao, Baiqi., ... & Ye, Fangfu. (2021). NIR-triggered upconversion nanoparticles@thermo-sensitive liposome hybrid theranostic nanoplatform for controlled drug delivery. RSC ADVANCES, 11(46), 29065-29072.
MLA	Yu, Yibin,et al."NIR-triggered upconversion nanoparticles@thermo-sensitive liposome hybrid theranostic nanoplatform for controlled drug delivery".RSC ADVANCES 11.46(2021):29065-29072.