Effects of curcumin on sodium currents of dorsal root ganglion neurons in type 2 diabetic neuropathic pain rats

doi:10.13459/j.cnki.cjap.2015.06.009

科研成果详情

题名	Effects of curcumin on sodium currents of dorsal root ganglion neurons in type 2 diabetic neuropathic pain rats
作者	Meng Bo 1; Shen Lulu 1; Shi Xiaoting 1; Gong Yongsheng2; Fan Xiaofang2; Li Jun1; Cao Hong1
发表日期	2015
发表期刊	中国应用生理学杂志影响因子和分区
语种	英语
原始文献类型	期刊论文
关键词	type 2 diabetic mellitus diabetic neuropathic pain dorsal root ganglion sodium currents curcumin
摘要	Along with the development of economy and society, type 2 diabetic mellitus (T2DM) has become one of the most common diseases at the global level. As one of the complications of T2DM, diabetic neuropathic pain (DNP) stubbornly and chronically affects the health and life of human beings. In the pain field, dorsal root ganglion (DRG) is generally considered as the first stage of the sensory pathway where the hyperexcitability of injured neurons is associated with different kinds of peripheral neuropathic pains. The abnormal electrophysiology is mainly due to the changed properties of voltage-gated sodium channels (VGSCs) and the increased sodium currents (I_(Na)). Curcumin is an active ingredient extracted from turmeric and has been demonstrated to ameliorate T2DM and its various complications including DNP effectively. The present study demonstrates that the I_(Na) of small-sized DRG neurons are significantly increased with the abnormal electrophysiological characteristics of VGSCs in type 2 diabetic neuropathic pain rats. And these abnormalities can be ameliorated efficaciously by a period of treatment with curcumin.
资助项目	supported by a grant from the National Natural Science Foundation of China ; 浙江省自然科学基金
ISSN	1000-6834
卷号	31 期号:6 页码:541-548
DOI	10.13459/j.cnki.cjap.2015.06.009
收录类别	CSCD
学科领域	医药、卫生 ; 中国医学
CSCD记录号	CSCD:5617736
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/99372
专题	第二临床医学院，附属第二医院、育英儿童医院附属第二医院基础医学院（机能实验教学中心）_基础医学实验教学中心_机能实验教学中心（挂靠、校级）
作者单位	1.Department of Anesthesiology, the 2nd Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325027 ; 2.Teaching Center of Medical Functional Experiment, Wenzhou Medical University, Wenzhou, 325035
第一作者单位	第二临床医学院，附属第二医院、育英儿童医院; 附属第二医院
第一作者的第一单位	第二临床医学院，附属第二医院、育英儿童医院; 附属第二医院
推荐引用方式 GB/T 7714	Meng Bo,Shen Lulu,Shi Xiaoting,et al. Effects of curcumin on sodium currents of dorsal root ganglion neurons in type 2 diabetic neuropathic pain rats[J]. 中国应用生理学杂志,2015,31(6):541-548.
APA	Meng Bo., Shen Lulu., Shi Xiaoting., Gong Yongsheng., Fan Xiaofang., ... & Cao Hong. (2015). Effects of curcumin on sodium currents of dorsal root ganglion neurons in type 2 diabetic neuropathic pain rats. 中国应用生理学杂志, 31(6), 541-548.
MLA	Meng Bo,et al."Effects of curcumin on sodium currents of dorsal root ganglion neurons in type 2 diabetic neuropathic pain rats".中国应用生理学杂志 31.6(2015):541-548.

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