心肌肌钙蛋白I独立预测严重脓毒症及感染性休克患者死亡率的价值研究

doi:10.3969/j.issn.1002-1949.2016.04.002

科研成果详情

题名	心肌肌钙蛋白I独立预测严重脓毒症及感染性休克患者死亡率的价值研究
其他题名	Cardiac troponin I can independently predicts mortality in patients with severe sepsis and septic shock
作者	胡甜甜; 赵光举; 洪广亮; 李萌芳; 支绍册; 吴斌; 卢中秋
发表日期	2016
发表期刊	中国急救医学影响因子和分区
语种	中文
原始文献类型	期刊论文
关键词	严重脓毒症感染性休克心肌肌钙蛋白I(cTnI) 病死率
其他关键词	Severe sepsis ; Septic shock ; Cardiac troponinⅠ (cTnⅠ) ; Mortality
摘要	目的评价心肌肌钙蛋白I(cTnl)对严重脓毒症及感染性休克患者预后的预测价值。方法回顾性分析2013-01-01~2014-12-31入住我院EICU、ICU的严重脓毒症、感染性休克患者86例的临床资料。按照cTnl是否大于0.08 ng/mL分为I组(cTnI≤0.08 ng/mL)和Ⅱ组(cTnl > 0.08 ng/mL),比较两组总住院病死率、ICU病死率、总住院天数及ICU住院天数。按照入院28 d是否存活分为存活组和死亡组,比较两组cTnl是否有差异及其对预后的预测价值。结果一共纳入研究的患者为86例,I组与Ⅱ组比较总住院病死率(12.5%vs.50.9%)、ICU病死率(12.5%vs.42.6%)差异有统计学意义(P<0.01),总住院天数[10(7,17)d vs.11(6,20)d]、ICU住院天数[4(2, 9)dvs.6(3,9)d]差异无统计学意义(P>0.05);存活组体温、呼吸、心率、cTnI、乳酸、器官受累数量及APACHE Ⅱ评分均较死亡组明显下降(均P < 0.01),而年龄、性别、血压、白细胞、血小板等指标两组比较差异无统计学意义(均P> 0.05)。Logistic回归分析显示,cTnI > 0.08 ng/mL、体温、乳酸及器官受累数量对预后有预测价值。结论cTnl>0.08 ng/mL的严重脓毒症及感染性休克患者的总住院病死率、ICU病死率较CTnI≤0.08 ng/mL的患者增加,且cTnl可作为预测患者病死率的独立指标。
其他摘要	Objective To evaluate the prognostic value of cardiac troponin I in severe sepsis and septic shock patients. Methods We retrospectively selected 86 severe sepsis and septic shock patients who admitted to EICU, ICU of our hospital from Jan.1, 2013 to Dec.13, 2014. According to cTnl levels the patients were divided to group I (cTnI≤0.08 ng/mL) and group Ⅱ (cTnl > 0.08 ng/mL); total hospital mortality, ICU mortality and total hospitalization days and the ICU hospitalization days between the two groups were compared. According to whether the survival of the hospital 28 days they were divided into survival group and death group; cTnl level was statistically compared and its prognostic value was also evaluated. Results A total of 86 patients were recruited in the study. Group I compared with group Ⅱ, the total hospital mortality (12.5% compared to 50.9%, P < 0.01); ICU mortality (12.5% compared to 42.6%, P<0.01); the total number of hospital days [10 (7,17) than 11 (6,20), P>0.05]; ICU hospitalization days [4 (2,9) than 6 (3,9), P>0.05]. Survival group compared with death group, its body temperature, breathing, heart rate, cTnl, lactic acid, the number of organ involvement and APACHE Ⅱ scores were significantly lower than those in the death group (P<0.01), but age, sex, blood pressure, leukocytes, platelets and other indicators had no obvious difference compared with the death group (P>0.05). Using logistic regression analysis of cardiac cTnl > 0.08 ng/mL, temperature, lactic acid and number of organ involvement can be used as an independent predictor of mortality in hospitalized patients. Conclusion cTnl > 0.08 ng/mL in patients with severe sepsis and septic shock, their total hospital mortality rates and ICU mortality increases and cTnl can be used as an independent predictor of mortality.
资助项目	国家自然科学基金 ; 浙江省医学创新学科建设计划 ; 浙江省中医药重点学科计划 ; 浙江省“十二五”重点学科建设项目
ISSN	1002-1949
卷号	36 期号:4 页码:294-298
DOI	10.3969/j.issn.1002-1949.2016.04.002
页数	5
收录类别	CSCD ; 万方 ; 维普 ; PKU ; 北大核心 ; ISTIC
学科领域	医药、卫生
URL	查看原文
CSCD记录号	CSCD:5709643
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/99060
专题	第一临床医学院（信息与工程学院）、附属第一医院_急诊医学附属第一医院
作者单位	温州医科大学第一附属医院急诊医学中心, 浙江, 温州, 325000
第一作者单位	急诊医学
第一作者的第一单位	急诊医学
推荐引用方式 GB/T 7714	胡甜甜,赵光举,洪广亮,等. 心肌肌钙蛋白I独立预测严重脓毒症及感染性休克患者死亡率的价值研究[J]. 中国急救医学,2016,36(4):294-298.
APA	胡甜甜., 赵光举., 洪广亮., 李萌芳., 支绍册., ... & 卢中秋. (2016). 心肌肌钙蛋白I独立预测严重脓毒症及感染性休克患者死亡率的价值研究. 中国急救医学, 36(4), 294-298.
MLA	胡甜甜,et al."心肌肌钙蛋白I独立预测严重脓毒症及感染性休克患者死亡率的价值研究".中国急救医学 36.4(2016):294-298.